GPR37 and HLA-C

Number of citations of the paper that reports this interaction (PubMedID 28298427)
90

Data Source:
BioGRID (two hybrid)

		GPR37	HLA-C
Description		G protein-coupled receptor 37	major histocompatibility complex, class I, C
Image		No pdb structure
GO Annotations	Cellular Component	Ubiquitin Ligase Complex Cytoplasm Endoplasmic Reticulum Endoplasmic Reticulum Membrane Plasma Membrane Cell Surface Membrane Dendrite Cell Projection Receptor Complex Synapse	Golgi Membrane Extracellular Space Endoplasmic Reticulum Endoplasmic Reticulum Membrane Golgi Apparatus Plasma Membrane External Side Of Plasma Membrane Cell Surface ER To Golgi Transport Vesicle Membrane Membrane Secretory Granule Membrane Phagocytic Vesicle Membrane Early Endosome Membrane MHC Class I Protein Complex Recycling Endosome Membrane Extracellular Exosome Lumenal Side Of Endoplasmic Reticulum Membrane
	Molecular Function	G Protein-coupled Receptor Activity Protein Binding Neuropeptide Receptor Activity G Protein-coupled Peptide Receptor Activity PDZ Domain Binding Hsp70 Protein Binding Heat Shock Protein Binding Ubiquitin Protein Ligase Binding Prosaposin Receptor Activity Peptide Binding Neuropeptide Binding	Signaling Receptor Binding Protein Binding Peptide Antigen Binding TAP Binding Receptor Ligand Activity
	Biological Process	Signal Transduction G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-inhibiting G Protein-coupled Receptor Signaling Pathway Neuropeptide Signaling Pathway Dendrite Development Locomotion Involved In Locomotory Behavior Cellular Response To Reactive Oxygen Species Dopamine Biosynthetic Process Positive Regulation Of MAPK Cascade Positive Regulation Of Dopamine Metabolic Process	Positive Regulation Of T Cell Mediated Cytotoxicity Adaptive Immune Response Immune System Process Antigen Processing And Presentation Of Peptide Antigen Via MHC Class I Antigen Processing And Presentation Of Endogenous Peptide Antigen Via MHC Class Ib Antigen Processing And Presentation Of Endogenous Peptide Antigen Via MHC Class I Via ER Pathway, TAP-independent Immune Response Signal Transduction Antigen Processing And Presentation Innate Immune Response Positive Regulation Of Natural Killer Cell Mediated Cytotoxicity
Pathways		Peptide ligand-binding receptors G alpha (i) signalling events	ER-Phagosome pathway ER-Phagosome pathway Endosomal/Vacuolar pathway Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell DAP12 interactions Neutrophil degranulation Interferon gamma signaling Interferon alpha/beta signaling SARS-CoV-2 activates/modulates innate and adaptive immune responses Antigen Presentation: Folding, assembly and peptide loading of class I MHC Antigen Presentation: Folding, assembly and peptide loading of class I MHC
Drugs
Diseases
GWAS		Ankylosing spondylitis ( 23749187) Cutaneous malignant melanoma ( 26237428 32341527) Nevus count or cutaneous melanoma ( 32341527) Reading and spelling ( 23738518) Refractive error ( 32231278)	A body shape index ( 34021172) AIDS progression ( 19115949) Albumin-globulin ratio ( 29403010) Allergic rhinitis ( 30013184) Allergic sensitization ( 23817571) Asthma ( 27182965 31619474) Asthma (adult onset) ( 31036433) Asthma (childhood onset) ( 31036433 31619474) Asthma and major depressive disorder ( 31619474) Atopic dermatitis ( 23042114 25574825) Autism spectrum disorder or schizophrenia ( 28540026) Basal cell carcinoma ( 33549134) Basophil count ( 32888494) Beta-2 microglubulin plasma levels ( 23417110) Birth weight ( 31043758) Blood cell traits (multivariate analysis) ( 31080455) C-reactive protein levels or triglyceride levels (pleiotropy) ( 27286809) Cancer ( 27197191) Cancer (pleiotropy) ( 27197191) Cervical cancer ( 28806749) Chickenpox ( 28928442) Childhood ear infection ( 27182965 28928442) Cholesterol, total ( 26582766) Chronic hepatitis B infection ( 25802187) Chronic obstructive pulmonary disease-related biomarkers ( 23144326) Cold sores ( 28928442) Complement C3 and C4 levels ( 23028341) Coronary heart disease ( 22319020) Crohn's disease ( 23128233 26891255) Cutaneous psoriasis ( 26626624) Decline in glucose metabolism in posterior cingulate cortex ( 29130521) Drug-induced liver injury (flucloxacillin) ( 30661239) Eosinophil percentage of white cells ( 32888494) Estimated glomerular filtration rate ( 31015462) Feeling hurt ( 29500382) Feeling nervous ( 29500382) Feeling worry ( 29500382) Granulocyte count ( 27863252) Granulocyte percentage of myeloid white cells ( 27863252) Height ( 23563607 25282103 31562340) Hematuria ( 30476138) Hematuria (mild) ( 30476138) Hematuria (moderate to severe) ( 30476138) Hemoglobin concentration ( 27863252) Hemoglobin levels ( 32327693) Hepatitis B ( 24162738) High light scatter reticulocyte percentage of red cells ( 32888494) Hip circumference adjusted for BMI ( 34021172) HIV-1 control ( 20041166 21051598) HIV-1 susceptibility ( 23935489) HIV-1 viral setpoint ( 26039976) Hypothyroidism ( 22493691) IgE levels ( 24324648) IgG galactosylation phenotypes (multivariate analysis) ( 28878392) Inflammatory bowel disease ( 28067908) Irritable bowel syndrome ( 33608531) Itch intensity from mosquito bite adjusted by bite size ( 28199695) LDL cholesterol ( 26582766) Leprosy ( 32421744) Leukoderma in response to rhododendrol ( 32558222) Lung cancer ( 28604730) Lymphocyte count ( 27863252 32888494) Major depressive disorder and major depressive episode treated with electroconvulsive therapy ( 33483693) Major depressive episode treated with electroconvulsive therapy ( 33483693) Mean corpuscular hemoglobin ( 29403010) Mean corpuscular volume ( 29403010) Mean platelet volume ( 32888494) Monocyte count ( 29403010) Monocyte percentage of white cells ( 32888494) Myeloid white cell count ( 27863252) Myositis ( 26291516) Nasopharyngeal carcinoma ( 20512145) Neurociticism ( 29500382) Neuromyelitis optica ( 29769526) Neuromyelitis optica (AQP4-IgG-positive) ( 29769526) Neutrophil count ( 27863252 29403010 32888494) Nevirapine-induced hypersensitivity in HIV (Stevens-Johnson syndrome or toxic epidermal necrosis) ( 28062682) Non-albumin protein levels ( 29403010) Offspring birth weight ( 31043758) Perceived unattractiveness to mosquitoes ( 28199695) Plantar warts ( 28928442) Pneumonia ( 28928442) Protein quantitative trait loci ( 18464913) Psoriasis ( 18364390 18369459 19169254 20953188 20953190 23143594 30921485) Psoriasis vulgaris ( 26626624) Psoriatic arthritis ( 20953186 26626624) Red blood cell count ( 32888494) Response to hepatitis B vaccine ( 29534301) Reticulocyte count ( 27863252) Rosacea symptom severity ( 29771307) Sarcoidosis (Lofgren's syndrome vs non-Lofgren's syndrome) ( 26651848) Self-reported allergy ( 23817569) Serum albumin levels ( 29403010) Setpoint viral load in HIV-1 infection ( 26553974) Severity of facial solar lentigines ( 27327535) Shingles ( 28928442) Small cell lung carcinoma ( 28604730) Squamous cell lung carcinoma ( 28604730) Stevens-Johnson syndrome and toxic epidermal necrolysis (SJS-TEN) ( 21912425) Sum basophil neutrophil counts ( 27863252) Sum neutrophil eosinophil counts ( 27863252) Systemic lupus erythematosus ( 28714469) Takayasu arteritis ( 25604533) Tonsillectomy ( 27182965 28928442) Tonsillitis ( 30037793) Triglyceride levels ( 33339817) Tuberculosis ( 28928442) Type 1 diabetes (age at diagnosis) ( 33179336) Ulcerative colitis ( 28067908) Vitiligo ( 20526339) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172) Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour) ( 28443625) Waist-to-hip ratio adjusted for BMI (joint analysis main effects and smoking interaction) ( 28443625) Waist-to-hip ratio adjusted for BMI in non-smokers ( 28443625) White blood cell count ( 21738480 27863252 28158719 29403010 32888494) White blood cell count (basophil) ( 29403010) White blood cell count (lymphocyte) ( 28158719)
Interacting Genes		51 interacting genes: ADGRB1 ADORA2A ADRA1A ADRB2 BNIP3 CCNQ CNTN1 DRD2 ERGIC3 FA2H FKBP8 FUCA2 G6PC3 GABARAPL2 GABBR1 GHITM GLP1R GPR17 GRIP1 HDGF HLA-C HSP90B1 HSPA1A HTR2C HTR4 IFITM3 JKAMP LTB4R2 P4HTM PPM1J PRKN SDCBP SLC37A1 SLC3A2 SLC41A3 SLC8A2 SPATA2L STUB1 SYVN1 TAFA5 TMED1 TMEM161A TMEM175 TMEM231 TMEM63A TTYH1 TTYH2 WLS YIF1A YIF1B ZDHHC11	25 interacting genes: ACKR5 B2M BATF2 CALR CD8A CDC25A GPR37 HSPA5 KIR2DL1 KIR2DL2 KIR2DL3 KIR2DS1 KIR2DS2 KIR2DS4 LILRB1 LILRB2 MAPK8IP2 NPSR1 OPRL1 PRRG4 TANK TAP2 TAPBP UBC YBX1
Entrez ID		2861	3107
HPRD ID		03992	00829
Ensembl ID		ENSG00000170775	ENSG00000204525
Uniprot IDs		O15354	O19617 P10321 Q6R739 Q95HC2
PDB IDs			1EFX 1IM9 1QQD 3BZF 4NT6 5VGD 5VGE 5W67 5W69 5W6A 6JTO 6PA1 6PAG
Enriched GO Terms of Interacting Partners?		Endoplasmic Reticulum Membrane Membrane Endoplasmic Reticulum G Protein-coupled Receptor Activity G Protein-coupled Receptor Signaling Pathway COPII-coated ER To Golgi Transport Vesicle Regulation Of Catecholamine Secretion Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway Dendrite ERAD Pathway Synaptic Transmission, Dopaminergic Regulation Of Autophagy Of Mitochondrion Cell Communication Negative Regulation Of Endoplasmic Reticulum Stress-induced Intrinsic Apoptotic Signaling Pathway Chemical Synaptic Transmission Regulation Of Membrane Potential Regulation Of Dopamine Secretion Cell-cell Signaling Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Signal Transduction Trans-synaptic Signaling Signaling Regulation Of Amine Transport Synaptic Signaling Modulation Of Chemical Synaptic Transmission Neuron-glial Cell Signaling Response To Psychosocial Stress Cellular Localization Synapse Positive Regulation Of Autophagy Of Mitochondrion Golgi Membrane Negative Regulation Of Dopamine Secretion Transmembrane Transport Response To Endoplasmic Reticulum Stress G Protein-coupled Receptor Binding Cellular Response To Topologically Incorrect Protein Endoplasmic Reticulum-Golgi Intermediate Compartment Membrane Glucose-6-phosphate Transport Volume-sensitive Chloride Channel Activity Establishment Of Localization In Cell Dopamine Uptake Involved In Synaptic Transmission Positive Regulation Of Neurotransmitter Uptake Volume-sensitive Anion Channel Activity Regulation Of Synaptic Transmission, GABAergic Intracellular Transport Plasma Membrane Calcium Ion Transmembrane Import Into Cytosol Regulation Of Endoplasmic Reticulum Stress-induced Intrinsic Apoptotic Signaling Pathway Regulation Of Response To Endoplasmic Reticulum Stress Negative Regulation Of Mitochondrial Fusion	MHC Class Ib Protein Binding MHC Class I Peptide Loading Complex Peptide Antigen Assembly With MHC Class I Protein Complex Immune Response-regulating Signaling Pathway MHC Class I Protein Binding Regulation Of Immune Response Immune Response-inhibiting Cell Surface Receptor Signaling Pathway Immune Response-inhibiting Signal Transduction Regulation Of Immune System Process Signal Transduction Antigen Processing And Presentation Of Exogenous Protein Antigen Via MHC Class Ib, TAP-dependent MHC Class Ib Protein Complex Binding Plasma Membrane Antigen Processing And Presentation Of Endogenous Peptide Antigen Via MHC Class I Phagocytic Vesicle Membrane Endoplasmic Reticulum-Golgi Intermediate Compartment Membrane Antigen Processing And Presentation Of Endogenous Antigen Antigen Processing And Presentation Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class Ib TAP1 Binding Antigen Processing And Presentation Of Peptide Antigen Via MHC Class I T Cell Mediated Immunity Peptide Antigen Binding Fc Receptor Mediated Inhibitory Signaling Pathway Immune System Process Immune Response Regulation Of T Cell Mediated Cytotoxicity MHC Class I Protein Complex Binding Inhibitory MHC Class I Receptor Activity Immune Response-regulating Cell Surface Receptor Signaling Pathway Membrane Adaptive Immune Response Ubiquitin Protein Ligase Binding Protein Folding Chaperone Interleukin-10-mediated Signaling Pathway Antigen Processing And Presentation Of Peptide Antigen Protein Folding In Endoplasmic Reticulum Protein Folding Regulation Of Dendritic Cell Differentiation Amyloid-beta Binding T Cell Mediated Cytotoxicity Regulation Of Leukocyte Mediated Cytotoxicity Neuropeptide Receptor Activity Negative Regulation Of Monoatomic Ion Transport Protein-folding Chaperone Binding Neuropeptide Signaling Pathway Regulation Of T Cell Mediated Immunity Adaptive Immune Response Based On Somatic Recombination Of Immune Receptors Built From Immunoglobulin Superfamily Domains Positive Regulation Of Immune System Process Unfolded Protein Binding
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