GPR37 and CCNQ

Number of citations: 90 (PubMedID 28298427)
Data Source: BioGRID (two hybrid)

		GPR37	CCNQ
Name		G protein-coupled receptor 37	cyclin Q
Structure		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Ubiquitin Ligase Complex Cytoplasm Endoplasmic Reticulum Endoplasmic Reticulum Membrane Plasma Membrane Cell Surface Membrane Dendrite Cell Projection Receptor Complex Synapse	Cyclin-dependent Protein Kinase Holoenzyme Complex Nucleus
	Molecular Function	G Protein-coupled Receptor Activity Protein Binding Neuropeptide Receptor Activity G Protein-coupled Peptide Receptor Activity PDZ Domain Binding Hsp70 Protein Binding Heat Shock Protein Binding Ubiquitin Protein Ligase Binding Prosaposin Receptor Activity Peptide Binding Neuropeptide Binding	Protein Binding Cyclin-dependent Protein Serine/threonine Kinase Regulator Activity
	Biological Process	Signal Transduction G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-inhibiting G Protein-coupled Receptor Signaling Pathway Neuropeptide Signaling Pathway Dendrite Development Locomotion Involved In Locomotory Behavior Cellular Response To Reactive Oxygen Species Dopamine Biosynthetic Process Positive Regulation Of MAPK Cascade Positive Regulation Of Dopamine Metabolic Process	Regulation Of Transcription By RNA Polymerase II Regulation Of Cell Cycle G2/M Phase Transition
Pathways		Peptide ligand-binding receptors G alpha (i) signalling events	None
GWAS		Ankylosing spondylitis ( 23749187 ) Cutaneous malignant melanoma ( 26237428 32341527 ) Nevus count or cutaneous melanoma ( 32341527 ) Reading and spelling ( 23738518 ) Refractive error ( 32231278 )	No GWAS studies recorded
Interacting Genes		51 interacting genes: ADGRB1 ADORA2A ADRA1A ADRB2 BNIP3 CCNQ CNTN1 DRD2 ERGIC3 FA2H FKBP8 FUCA2 G6PC3 GABARAPL2 GABBR1 GHITM GLP1R GPR17 GRIP1 HDGF HLA-C HSP90B1 HSPA1A HTR2C HTR4 IFITM3 JKAMP LTB4R2 P4HTM PPM1J PRKN SDCBP SLC37A1 SLC3A2 SLC41A3 SLC8A2 SPATA2L STUB1 SYVN1 TAFA5 TMED1 TMEM161A TMEM175 TMEM231 TMEM63A TTYH1 TTYH2 WLS YIF1A YIF1B ZDHHC11	2 interacting genes: GPR37 PTPN5
Entrez ID		2861	92002
HPRD ID		03992	06645
Ensembl ID		ENSG00000170775	ENSG00000262919
Uniprot IDs		O15354	Q8N1B3
PDB IDs		Not available	Not available
GO Terms Enriched among Interactors		Endoplasmic Reticulum Membrane Membrane Endoplasmic Reticulum G Protein-coupled Receptor Activity G Protein-coupled Receptor Signaling Pathway COPII-coated ER To Golgi Transport Vesicle Regulation Of Catecholamine Secretion Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway Dendrite ERAD Pathway Synaptic Transmission, Dopaminergic Regulation Of Autophagy Of Mitochondrion Cell Communication Negative Regulation Of Endoplasmic Reticulum Stress-induced Intrinsic Apoptotic Signaling Pathway Chemical Synaptic Transmission Regulation Of Membrane Potential Regulation Of Dopamine Secretion Cell-cell Signaling Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Signal Transduction Trans-synaptic Signaling Signaling Regulation Of Amine Transport Synaptic Signaling Modulation Of Chemical Synaptic Transmission Neuron-glial Cell Signaling Response To Psychosocial Stress Cellular Localization Synapse Positive Regulation Of Autophagy Of Mitochondrion Golgi Membrane Negative Regulation Of Dopamine Secretion Transmembrane Transport Response To Endoplasmic Reticulum Stress G Protein-coupled Receptor Binding Cellular Response To Topologically Incorrect Protein Endoplasmic Reticulum-Golgi Intermediate Compartment Membrane Glucose-6-phosphate Transport Volume-sensitive Chloride Channel Activity Establishment Of Localization In Cell Dopamine Uptake Involved In Synaptic Transmission Positive Regulation Of Neurotransmitter Uptake Volume-sensitive Anion Channel Activity Regulation Of Synaptic Transmission, GABAergic Intracellular Transport Plasma Membrane Calcium Ion Transmembrane Import Into Cytosol Regulation Of Endoplasmic Reticulum Stress-induced Intrinsic Apoptotic Signaling Pathway Regulation Of Response To Endoplasmic Reticulum Stress Negative Regulation Of Mitochondrial Fusion	Prosaposin Receptor Activity Positive Regulation Of Dopamine Metabolic Process Locomotion Involved In Locomotory Behavior Dopamine Biosynthetic Process Regulation Of Dopamine Metabolic Process Amine Biosynthetic Process Neuropeptide Binding Endoplasmic Reticulum Membrane Catecholamine Biosynthetic Process Peptide Binding Biogenic Amine Biosynthetic Process Neuropeptide Receptor Activity Dopamine Metabolic Process G Protein-coupled Peptide Receptor Activity Dendrite Development Catecholamine Metabolic Process Hsp70 Protein Binding Phosphotyrosine Residue Binding Endoplasmic Reticulum Biogenic Amine Metabolic Process Heat Shock Protein Binding Adenylate Cyclase-inhibiting G Protein-coupled Receptor Signaling Pathway Phenol-containing Compound Metabolic Process Amine Metabolic Process PDZ Domain Binding Protein Dephosphorylation Protein Tyrosine Phosphatase Activity Neuropeptide Signaling Pathway Ubiquitin Ligase Complex Cellular Response To Reactive Oxygen Species Dephosphorylation Phosphoprotein Phosphatase Activity