GLP1R and GJB1

Number of citations of the paper that reports this interaction (PubMedID 28597972)
0

Data Source:
BioGRID (protein complementation assay)

		GLP1R	GJB1
Description		glucagon like peptide 1 receptor	gap junction protein beta 1
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GO Annotations	Cellular Component	Plasma Membrane Membrane	Cytoplasm Endoplasmic Reticulum Membrane Plasma Membrane Gap Junction Connexin Complex Membrane Anchoring Junction
	Molecular Function	Transmembrane Signaling Receptor Activity G Protein-coupled Receptor Activity Glucagon Receptor Activity Protein Binding G Protein-coupled Peptide Receptor Activity Peptide Hormone Binding Signaling Receptor Activity Glucagon-like Peptide 1 Receptor Activity	Gap Junction Channel Activity Protein Binding Identical Protein Binding
	Biological Process	Signal Transduction Cell Surface Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Activation Of Adenylate Cyclase Activity Positive Regulation Of Cytosolic Calcium Ion Concentration Learning Or Memory Regulation Of Heart Contraction Post-translational Protein Targeting To Membrane, Translocation Negative Regulation Of Blood Pressure Positive Regulation Of Blood Pressure Hormone Secretion Regulation Of Biological Quality Cellular Response To Glucagon Stimulus Response To Psychosocial Stress	Cell Communication Cell-cell Signaling Nervous System Development Gap Junction Assembly Transmembrane Transport
Pathways		Glucagon-like Peptide-1 (GLP1) regulates insulin secretion Glucagon-like Peptide-1 (GLP1) regulates insulin secretion G alpha (s) signalling events Glucagon-type ligand receptors	Oligomerization of connexins into connexons Oligomerization of connexins into connexons Transport of connexins along the secretory pathway Gap junction assembly
Drugs		Glucagon Exenatide Liraglutide Albiglutide Dulaglutide Lixisenatide Semaglutide Taspoglutide Tirzepatide Efpeglenatide Glutazumab
Diseases			Charcot-Marie-Tooth disease (CMT); Hereditary motor and sensory neuropathy; Peroneal muscular atrophy
GWAS		Blood sugar levels ( 29403010) Fasting blood glucose ( 25631608) Fasting blood glucose adjusted for BMI ( 25625282) Fasting glucose ( 34059833) Type 2 diabetes ( 32499647)
Interacting Genes		112 interacting genes: ACSF3 AGXT AIG1 APH1A ARFRP1 ARLN ASGR2 ATP13A1 ATP5MC3 ATP6AP2 C18orf32 CALM1 CAND2 CAV1 CCDC167 CD63 CD81 CELA3B CEND1 CFI CLDN7 CLIP4 CLPS CNIH4 COMT CYSRT1 CYSTM1 DAD1 DHRS7 EBP ELOVL1 EMC7 EMP2 ERP29 FGL1 FTL GABBR2 GCG GJB1 GNAS GP2 GPR108 GPR37 GPRASP1 GRINA HAMP HPN IER3 IFITM3 KHK KRTAP1-1 KRTAP1-3 KRTAP10-3 KRTAP10-7 KRTAP10-8 KRTAP10-9 KRTAP17-1 KRTAP5-9 LAPTM4A LINC00269 MRPL22 MT-ATP6 MT-ND4L MTCH2 MYL6 NBPF19 NOTCH2NLA NRGN NUCKS1 OCIAD2 OST4 P4HTM PAM PAQR6 PGRMC1 PIGG POMT2 PPIB PRSS2 PSMD8 RAB5B RAB5C RNF5 RTN3 RTN4 RTRAF SAA1 SCGB2A1 SEC11C SELENOK SERPINA1 SLC15A4 SLC37A4 SLC61A1 SLC9D1 SPTSSA STMN1 STMN3 STOML2 SVOP SYNGR3 SYNGR4 SYS1 TM4SF4 TMBIM6 TMEM147 TMEM176B TOMM6 TSPAN13 UGT1A9 VAPB ZNF99	57 interacting genes: APOL3 APP BMP10 C1GALT1 C2CD2L C3orf52 CALM1 CD37 CD79A CDIPT CLEC7A CMTM3 CMTM5 CNST COMT CTXN3 CXCL9 EFNA5 EGFR EMP3 EPHA1 GJB2 GLP1R GPR25 IER3IP1 ITGAM LAT LHFPL2 MAL MAL2 MFF MS4A13 MST1R NDUFB11 NIPAL4 PRKACA PRKCA PTPN2 PTPN9 RTP2 SCD SERTM1 SLC12A7 SRC STX8 TEX264 TF TM4SF4 TMEM120B TMEM14C TMEM19 TMEM218 TMEM98 UPK1B VEGFA VKORC1 YIPF6
Entrez ID		2740	2705
HPRD ID		00677	02367
Ensembl ID		ENSG00000112164	ENSG00000169562
Uniprot IDs		A0A142FHB8 P43220	P08034
PDB IDs		3C59 3C5T 3IOL 4ZGM 5E94 5NX2 5OTT 5OTU 5OTV 5OTW 5OTX 5VEW 5VEX 6B3J 6GB1 6ORV 6VCB 6X18 6X19 6X1A 6XOX 7C2E 7DUQ 7DUR 7E14 7EVM 7FIM 7KI0 7KI1 7LCI 7LCJ 7LCK 7LLL 7LLY 7RG9 7RGP 7RTB 7S15 7S1M 7S3I 7VBH 7VBI 7X8R 7X8S 8JIP 8JIR 8JIS 8WG7 8YW3 9IVG 9IVM 9J1P	5KK9 7ZXM 7ZXN 7ZXO 7ZXP 7ZXQ 7ZXT 8QJF 8QJH 8QK6 8QKI
Enriched GO Terms of Interacting Partners?		Endoplasmic Reticulum Membrane Membrane Endoplasmic Reticulum Intermediate Filament Host-mediated Perturbation Of Viral Genome Replication Host-mediated Activation Of Viral Genome Replication Keratin Filament Neutrophil Migration Host-mediated Activation Of Viral Process Endoplasmic Reticulum Membrane Organization Chemical Homeostasis Intracellular Chemical Homeostasis Synaptic Vesicle Membrane Intracellular Calcium Ion Homeostasis Intracellular Monoatomic Cation Homeostasis Granulocyte Migration	Membrane Plasma Membrane Membrane Raft Regulation Of Protein Localization Positive Regulation Of Protein Localization Intestinal Epithelial Cell Development Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Cell Surface Receptor Signaling Pathway Columnar/cuboidal Epithelial Cell Development Protein Binding Endoplasmic Reticulum Regulation Of Superoxide Anion Generation Positive Regulation Of Cell Communication Positive Regulation Of Signaling Positive Regulation Of Signal Transduction Positive Regulation Of Superoxide Anion Generation Regulation Of Cellular Localization Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Positive Regulation Of Cellular Component Organization Positive Regulation Of Intracellular Signal Transduction Regulation Of Vesicle-mediated Transport Positive Regulation Of Transport Positive Regulation Of Phosphate Metabolic Process Positive Regulation Of Establishment Of Protein Localization Leukocyte Activation Regulation Of Phosphorus Metabolic Process Ephrin Receptor Binding Connexin Binding Regulation Of Superoxide Metabolic Process Positive Regulation Of Protein Phosphorylation Integrin Binding Positive Regulation Of MAPK Cascade Regulation Of Peptidyl-tyrosine Phosphorylation Positive Regulation Of Protein Transport Regulation Of Blood Circulation Positive Regulation Of Endocytosis Positive Regulation Of Phosphorylation Plasma Membrane Raft Membrane Raft Distribution Regulation Of Cell Junction Assembly Cell Surface Regulation Of Calcium-mediated Signaling Cell Activation Regulation Of MAPK Cascade Signaling Receptor Activator Activity Regulation Of Protein Phosphorylation Membrane Raft Localization Regulation Of Platelet-derived Growth Factor Receptor-beta Signaling Pathway Regulation Of Establishment Of Protein Localization Regulation Of ERK1 And ERK2 Cascade
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