GLP1R and ERP29

Number of citations of the paper that reports this interaction (PubMedID 23864651)
34

Data Source:
BioGRID (protein complementation assay, affinity chromatography technology)

		GLP1R	ERP29
Description		glucagon like peptide 1 receptor	endoplasmic reticulum protein 29
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GO Annotations	Cellular Component	Plasma Membrane Membrane	Endoplasmic Reticulum Endoplasmic Reticulum Lumen Smooth Endoplasmic Reticulum Cell Surface Membrane Melanosome
	Molecular Function	Transmembrane Signaling Receptor Activity G Protein-coupled Receptor Activity Glucagon Receptor Activity Protein Binding G Protein-coupled Peptide Receptor Activity Peptide Hormone Binding Signaling Receptor Activity Glucagon-like Peptide 1 Receptor Activity	Protein Disulfide Isomerase Activity Protein Binding Protein Homodimerization Activity Protein-folding Chaperone Binding
	Biological Process	Signal Transduction Cell Surface Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Activation Of Adenylate Cyclase Activity Positive Regulation Of Cytosolic Calcium Ion Concentration Learning Or Memory Regulation Of Heart Contraction Post-translational Protein Targeting To Membrane, Translocation Negative Regulation Of Blood Pressure Positive Regulation Of Blood Pressure Hormone Secretion Regulation Of Biological Quality Cellular Response To Glucagon Stimulus Response To Psychosocial Stress	Protein Folding Intracellular Protein Transport Protein Secretion Positive Regulation Of Gene Expression Negative Regulation Of Gene Expression Protein Unfolding Positive Regulation Of MAPK Cascade Negative Regulation Of Protein Secretion Regulation Of Endoplasmic Reticulum Stress-induced Intrinsic Apoptotic Signaling Pathway
Pathways		Glucagon-like Peptide-1 (GLP1) regulates insulin secretion Glucagon-like Peptide-1 (GLP1) regulates insulin secretion G alpha (s) signalling events Glucagon-type ligand receptors
Drugs		Glucagon Exenatide Liraglutide Albiglutide Dulaglutide Lixisenatide Semaglutide Taspoglutide Tirzepatide Efpeglenatide Glutazumab
Diseases
GWAS		Blood sugar levels ( 29403010) Fasting blood glucose ( 25631608) Fasting blood glucose adjusted for BMI ( 25625282) Fasting glucose ( 34059833) Type 2 diabetes ( 32499647)	Body mass index ( 26426971) Crohn's disease ( 28067908) Inflammatory bowel disease ( 28067908)
Interacting Genes		112 interacting genes: ACSF3 AGXT AIG1 APH1A ARFRP1 ARLN ASGR2 ATP13A1 ATP5MC3 ATP6AP2 C18orf32 CALM1 CAND2 CAV1 CCDC167 CD63 CD81 CELA3B CEND1 CFI CLDN7 CLIP4 CLPS CNIH4 COMT CYSRT1 CYSTM1 DAD1 DHRS7 EBP ELOVL1 EMC7 EMP2 ERP29 FGL1 FTL GABBR2 GCG GJB1 GNAS GP2 GPR108 GPR37 GPRASP1 GRINA HAMP HPN IER3 IFITM3 KHK KRTAP1-1 KRTAP1-3 KRTAP10-3 KRTAP10-7 KRTAP10-8 KRTAP10-9 KRTAP17-1 KRTAP5-9 LAPTM4A LINC00269 MRPL22 MT-ATP6 MT-ND4L MTCH2 MYL6 NBPF19 NOTCH2NLA NRGN NUCKS1 OCIAD2 OST4 P4HTM PAM PAQR6 PGRMC1 PIGG POMT2 PPIB PRSS2 PSMD8 RAB5B RAB5C RNF5 RTN3 RTN4 RTRAF SAA1 SCGB2A1 SEC11C SELENOK SERPINA1 SLC15A4 SLC37A4 SLC61A1 SLC9D1 SPTSSA STMN1 STMN3 STOML2 SVOP SYNGR3 SYNGR4 SYS1 TM4SF4 TMBIM6 TMEM147 TMEM176B TOMM6 TSPAN13 UGT1A9 VAPB ZNF99	21 interacting genes: ADIPOQ BMP10 C3orf52 CEBPA CTNNBL1 DESI1 GLP1R HMG20B HSPA5 NRM PUF60 SGTA SGTB SLC35B4 SLC38A7 TMBIM6 TMEM86B TSPO2 UBQLN1 UBQLN2 UBQLN4
Entrez ID		2740	10961
HPRD ID		00677	03794
Ensembl ID		ENSG00000112164	ENSG00000089248
Uniprot IDs		A0A142FHB8 P43220	P30040 V9HW71
PDB IDs		3C59 3C5T 3IOL 4ZGM 5E94 5NX2 5OTT 5OTU 5OTV 5OTW 5OTX 5VEW 5VEX 6B3J 6GB1 6ORV 6VCB 6X18 6X19 6X1A 6XOX 7C2E 7DUQ 7DUR 7E14 7EVM 7FIM 7KI0 7KI1 7LCI 7LCJ 7LCK 7LLL 7LLY 7RG9 7RGP 7RTB 7S15 7S1M 7S3I 7VBH 7VBI 7X8R 7X8S 8JIP 8JIR 8JIS 8WG7 8YW3 9IVG 9IVM 9J1P	2QC7 5V8Z 5V90
Enriched GO Terms of Interacting Partners?		Endoplasmic Reticulum Membrane Membrane Endoplasmic Reticulum Intermediate Filament Host-mediated Perturbation Of Viral Genome Replication Host-mediated Activation Of Viral Genome Replication Keratin Filament Neutrophil Migration Host-mediated Activation Of Viral Process Endoplasmic Reticulum Membrane Organization Chemical Homeostasis Intracellular Chemical Homeostasis Synaptic Vesicle Membrane Intracellular Calcium Ion Homeostasis Intracellular Monoatomic Cation Homeostasis Granulocyte Migration	Regulation Of Proteasomal Protein Catabolic Process Regulation Of Response To Endoplasmic Reticulum Stress TRC Complex Positive Regulation Of ERAD Pathway Regulation Of Protein Catabolic Process Regulation Of Proteolysis ERAD Pathway Regulation Of ERAD Pathway Response To Endoplasmic Reticulum Stress Positive Regulation Of Proteasomal Protein Catabolic Process Polyubiquitin Modification-dependent Protein Binding Positive Regulation Of Response To Endoplasmic Reticulum Stress Positive Regulation Of Proteolysis Involved In Protein Catabolic Process Identical Protein Binding Negative Regulation Of IRE1-mediated Unfolded Protein Response Negative Regulation Of Response To Endoplasmic Reticulum Stress Post-translational Protein Targeting To Membrane, Translocation Regulation Of Cellular Response To Stress Regulation Of Protein Metabolic Process Endoplasmic Reticulum Regulation Of Ubiquitin-dependent Protein Catabolic Process IRE1-mediated Unfolded Protein Response Post-translational Protein Targeting To Endoplasmic Reticulum Membrane Positive Regulation Of Proteolysis Positive Regulation Of Protein Catabolic Process Autophagosome Regulation Of IRE1-mediated Unfolded Protein Response Protein-containing Complex Negative Regulation Of Endoplasmic Reticulum Unfolded Protein Response Cellular Localization Positive Regulation Of Protein Metabolic Process Autophagy Brown Fat Cell Differentiation Protein Targeting To ER Intracellular Protein Transmembrane Transport Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Receptor-mediated Endocytosis Establishment Of Protein Localization To Endoplasmic Reticulum RNA Polymerase I Transcription Regulatory Region Sequence-specific DNA Binding Integrated Stress Response Signaling Glucagon-like Peptide 1 Receptor Activity Regulation Of Endoplasmic Reticulum Unfolded Protein Response Regulation Of Protein Folding In Endoplasmic Reticulum Negative Regulation Of Calcium Ion Transmembrane Transport Neuron Intrinsic Apoptotic Signaling Pathway In Response To Endoplasmic Reticulum Stress Negative Regulation Of Metanephric Mesenchymal Cell Migration Positive Regulation Of Renal Albumin Absorption Positive Regulation Of Metanephric Podocyte Development Positive Regulation Of Glycogen (starch) Synthase Activity Negative Regulation Of Store-operated Calcium Channel Activity
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