GLP1R and NUCKS1

Number of citations of the paper that reports this interaction (PMID 23864651)
0

Data Source:
BioGRID (protein complementation assay, affinity chromatography technology)

		GLP1R	NUCKS1
Gene Name		glucagon-like peptide 1 receptor	nuclear casein kinase and cyclin-dependent kinase substrate 1
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Plasma Membrane Integral Component Of Membrane	Nucleus Cytoplasm
	Molecular Function	Transmembrane Signaling Receptor Activity Glucagon Receptor Activity	Poly(A) RNA Binding
	Biological Process	Energy Reserve Metabolic Process Response To Stress G-protein Coupled Receptor Signaling Pathway Activation Of Adenylate Cyclase Activity Positive Regulation Of Cytosolic Calcium Ion Concentration Learning Or Memory Regulation Of Heart Contraction CAMP-mediated Signaling Small Molecule Metabolic Process Regulation Of Insulin Secretion Cellular Response To Glucagon Stimulus
Pathways		Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) Signaling by GPCR GPCR downstream signaling Glucagon-like Peptide-1 (GLP1) regulates insulin secretion Integration of energy metabolism G alpha (s) signalling events Regulation of insulin secretion Glucagon-type ligand receptors Metabolic disorders of biological oxidation enzymes GPCR ligand binding Class B/2 (Secretin family receptors)
Drugs		Glucagon recombinant Exenatide Liraglutide
Diseases
GWAS			Parkinson's disease ( 19915575 19915576) Prostate-specific antigen levels ( 23269536) Pubertal anthropometrics ( 23449627)
Protein-Protein Interactions		41 interactors: ACSF3 APH1A ARFRP1 ATP13A1 C14orf166 C18orf32 CALM1 CAND2 CEND1 CFI CYSTM1 ELOVL1 ERP29 GABBR2 GCG GPR37 GPRASP1 HPN IFITM3 KRTAP10-3 KRTAP10-7 KRTAP10-8 KRTAP10-9 MFSD5 MRPL22 MYL6 NOTCH2NL NRGN NUCKS1 P4HTM PAQR6 PIGG SLC15A4 STMN1 STMN3 STOML2 SUMO1 SVOP SYNGR3 TMEM147 TSPAN13	2 interactors: AK5 GLP1R
Entrez ID		2740	64710
HPRD ID		00677	11406
Ensembl ID		ENSG00000112164	ENSG00000069275
Uniprot IDs		P43220	B4DTY3 Q9H1E3
PDB IDs		3C59 3C5T 3IOL
Enriched GO Terms of Interacting Partners?		Microtubule Depolymerization Positive Regulation Of Peptidyl-threonine Phosphorylation Regulation Of CAMP Biosynthetic Process Regulation Of CAMP Metabolic Process Substantia Nigra Development Microtubule Polymerization Or Depolymerization Cerebellar Granular Layer Maturation Positive Regulation Of Cardiolipin Metabolic Process Protein Unfolding Positive Regulation Of Mitochondrial DNA Replication Stress-induced Mitochondrial Fusion Malonate Catabolic Process Molybdate Ion Transport	DADP Biosynthetic Process ADP Biosynthetic Process Deoxyribonucleoside Diphosphate Metabolic Process Nucleoside Diphosphate Biosynthetic Process ADP Metabolic Process Deoxyribonucleotide Biosynthetic Process Nucleobase-containing Small Molecule Interconversion CAMP-mediated Signaling Activation Of Adenylate Cyclase Activity Cyclic-nucleotide-mediated Signaling Positive Regulation Of Adenylate Cyclase Activity Cellular Response To Glucagon Stimulus Nucleoside Diphosphate Phosphorylation Pyrimidine Ribonucleotide Biosynthetic Process Positive Regulation Of Lyase Activity Deoxyribonucleotide Metabolic Process Response To Glucagon Pyrimidine Nucleotide Biosynthetic Process Regulation Of Adenylate Cyclase Activity Nucleotide Phosphorylation Nucleoside Diphosphate Metabolic Process Positive Regulation Of CAMP Biosynthetic Process Regulation Of Cyclase Activity Positive Regulation Of CAMP Metabolic Process Purine Ribonucleoside Monophosphate Biosynthetic Process Pyrimidine Nucleotide Metabolic Process Positive Regulation Of Cyclic Nucleotide Metabolic Process Nucleoside Triphosphate Biosynthetic Process Regulation Of CAMP Biosynthetic Process Ribonucleoside Monophosphate Biosynthetic Process Regulation Of CAMP Metabolic Process Nucleoside Monophosphate Biosynthetic Process Small Molecule Metabolic Process ATP Metabolic Process Energy Reserve Metabolic Process Second-messenger-mediated Signaling Positive Regulation Of Cytosolic Calcium Ion Concentration Regulation Of Heart Contraction Purine Nucleotide Biosynthetic Process Ribose Phosphate Biosynthetic Process Cytosolic Calcium Ion Homeostasis Regulation Of Insulin Secretion Regulation Of Peptide Hormone Secretion Purine Nucleoside Metabolic Process Regulation Of Hormone Secretion Learning Or Memory Cognition Cellular Calcium Ion Homeostasis Ribonucleotide Metabolic Process Nucleoside Metabolic Process
Tagcloud ?		2a cardiac cardiomyopathies cardioprotective ccaat chaperone chemoattractant chop endoplasmic ex4 exendin fibrosis glucagon gluco grp78 homologous incretin infarction infiltration lipotoxicity mcp1 mhc monocyte reperfusion reticulum sarco serca2a viable	association associations carcinoma casein clinicopathological cytokeratin distant epidermal estrogen grade grading histological histopathological immunohistochemical invasive involvement ki lymph markers metastases node pr progesterone regard special substrate subtype ubiquitous
Tagcloud (Difference) ?		2a cardiac cardiomyopathies cardioprotective ccaat chaperone chemoattractant chop endoplasmic ex4 exendin fibrosis glucagon gluco grp78 homologous incretin infarction infiltration lipotoxicity mcp1 mhc monocyte reperfusion reticulum sarco serca2a viable	association associations carcinoma casein clinicopathological cytokeratin distant epidermal estrogen grade grading histological histopathological immunohistochemical invasive involvement ki lymph markers metastases node pr progesterone regard special substrate subtype ubiquitous
Tagcloud (Intersection) ?