SNAPIN and KRT10

Number of citations of the paper that reports this interaction (PubMedID 23414517)
48

Data Source:
BioGRID (two hybrid)

		SNAPIN	KRT10
Description		SNAP associated protein	keratin 10
Image		No pdb structure
GO Annotations	Cellular Component	Golgi Membrane Acrosomal Vesicle Manchette Cytoplasm Lysosome Lysosomal Membrane Golgi Apparatus Cytosol Synaptic Vesicle Membrane Secretory Granule Synaptic Vesicle Membrane BLOC-1 Complex Cytoplasmic Vesicle Synapse Perinuclear Region Of Cytoplasm Cytoplasmic Side Of Lysosomal Membrane BORC Complex Axon Cytoplasm Microvesicle	Cornified Envelope Extracellular Region Extracellular Space Nucleus Cytoplasm Cytosol Cytoskeleton Intermediate Filament Cell Surface Membrane Keratin Filament Extracellular Exosome
	Molecular Function	SNARE Binding Protein Binding	Structural Molecule Activity Protein Binding Structural Constituent Of Skin Epidermis Protein Heterodimerization Activity
	Biological Process	Intracellular Protein Transport Exocytosis Lysosome Organization Lysosomal Lumen Acidification Chemical Synaptic Transmission Neurotransmitter Secretion Anterograde Axonal Transport Retrograde Axonal Transport Endosome To Lysosome Transport Negative Regulation Of Neuron Projection Development Synaptic Vesicle Exocytosis Synaptic Vesicle Maturation Neuron Projection Development Protein-containing Complex Localization Synaptic Vesicle Fusion To Presynaptic Active Zone Membrane Lysosome Localization Melanosome Organization Synaptic Vesicle Transport Anterograde Synaptic Vesicle Transport Regulation Of Endosome Size Protein Maturation Establishment Of Vesicle Localization Regulation Of Lysosome Size Neuron Cellular Homeostasis Organelle Transport Along Microtubule Terminal Button Organization Autophagosome Maturation Late Endosome To Lysosome Transport Positive Regulation Of Late Endosome To Lysosome Transport Regulation Of Synaptic Vesicle Exocytosis	Morphogenesis Of An Epithelium Peptide Cross-linking Keratinocyte Differentiation Intermediate Filament Organization Positive Regulation Of Epidermis Development Protein Heterotetramerization
Pathways		Golgi Associated Vesicle Biogenesis	Keratinization Formation of the cornified envelope Differentiation of Keratinocytes in Interfollicular Epidermis in Mammalian Skin
Drugs			Zinc Copper Zinc acetate
Diseases			Epidermolytic hyperkeratosis (EHK); Bullous congenital ichthyosiform erythroderma (BCIE) Ichthyosis with confetti; Congenital reticular ichthyosiform erythroderma; Ichthyosis variegata
GWAS			Glucose homeostasis traits ( 25524916)
Interacting Genes		103 interacting genes: ABI2 ACTN2 ATG14 ATP1A1 BANP BFSP1 BFSP2 BIN1 BLOC1S1 BLOC1S2 BLOC1S4 BLOC1S5 BLOC1S6 BNIPL C20orf202 CCDC102B CDC42BPA CEP170 CMYA5 CSNK1D DDR1 DENND1C DES DNM2 DOCK9 DST DTNBP1 DYRK3 DYSF EBAG9 EEF1G ELP1 ENO3 EXOC7 FAM114A1 FSD2 GPRASP1 GRIK1 HAP1 HMGB2 IKBIP IMMT KANK2 KAT5 KAT7 KIF5C KPNB1 KRT10 KRT15 KRT16 KRT17 KRT19 KRT20 KRT24 KRT26 LAMA2 LAMC1 LMNB1 LRP12 MACF1 MAPK14 MET MORC3 MTNR1A MYH14 MYH3 MYH7 NECAB2 NEDD9 NME7 NUP62CL PCYT1A PLAC9 PLEC PRKACA RABEP1 RABGEF1 RETREG1 RGS7 RNF13 SHBG SKA1 SMAD2 SMG1 SNAP23 SNAP25 SPAG5 SPP1 SPTB SPTBN1 ST7 TFIP11 TOMM70 TPM1 TPM2 TPM3 TPM4 TRIM63 TRPV1 TSG101 WASHC3 YWHAE YWHAZ	10 interacting genes: AKT1 ESR1 EVPL GLE1 OGT PRKCZ RNF26 SIRPA SMAD3 SNAPIN
Entrez ID		23557	3858
HPRD ID		06111	01021
Ensembl ID		ENSG00000143553	ENSG00000186395
Uniprot IDs		O95295	A0A1B0GVI3 P13645
PDB IDs			3ASW 4F1Z 4ZRY 6E2J 6EC0 6UUI
Enriched GO Terms of Interacting Partners?		Cytoskeleton Organization Cytoskeleton Intermediate Filament Cytoskeleton Organization Intermediate Filament-based Process Organelle Organization Intermediate Filament Organization Establishment Of Organelle Localization Intermediate Filament Supramolecular Fiber Organization Organelle Localization Structural Constituent Of Cytoskeleton BLOC-1 Complex Actin Filament Binding Synaptic Vesicle Transport Establishment Of Vesicle Localization Structural Molecule Activity Axo-dendritic Transport Axon Cytoplasm Axonal Transport Vesicle Localization Establishment Of Localization In Cell Anterograde Axonal Transport Cytosol Anterograde Synaptic Vesicle Transport Muscle Thin Filament Tropomyosin Structural Constituent Of Skin Epidermis Cytoplasm Transport Along Microtubule Vesicle Transport Along Microtubule Cellular Localization Cytoskeleton-dependent Intracellular Transport Vesicle Cytoskeletal Trafficking Regulation Of Cellular Component Organization Microtubule-based Transport Melanosome Organization Keratin Filament Intracellular Transport Pigment Granule Organization Structural Constituent Of Muscle Actomyosin Structure Organization Muscle System Process Actin Binding Muscle Contraction Extracellular Exosome Contractile Muscle Fiber Stress Fiber Organelle Transport Along Microtubule Tissue Morphogenesis Intracellular Protein Localization Z Disc	Regulation Of Nitric Oxide Biosynthetic Process Regulation Of Nitric Oxide Metabolic Process Positive Regulation Of Nitric Oxide Biosynthetic Process Positive Regulation Of Nitric Oxide Metabolic Process Regulation Of Defense Response Cellular Response To Oxygen-containing Compound Nitric-oxide Synthase Regulator Activity Intracellular Protein Localization Response To Hormone Response To Peptide Hormone Ciliary Basal Body Negative Regulation Of Cellular Component Organization Regulation Of Immune System Process Regulation Of Immune Response Response To Insulin Negative Regulation Of MiRNA Transcription Organelle Organization Positive Regulation Of Cell Adhesion Regulation Of Cellular Localization Maternal Process Involved In Female Pregnancy 14-3-3 Protein Binding Carbohydrate Homeostasis Glucose Homeostasis Regulation Of Toll-like Receptor Signaling Pathway Negative Regulation Of Gene Expression Phosphatidylinositol-3,4,5-trisphosphate Binding Protein K11-linked Ubiquitination Protein Metabolic Process Negative Regulation Of Translational Initiation Positive Regulation Of Translational Initiation Regulation Of Multicellular Organismal Process Regulation Of Intracellular Signal Transduction Transcription Corepressor Binding Positive Regulation Of T Cell Activation Transcription Coactivator Binding Positive Regulation Of Leukocyte Cell-cell Adhesion Negative Regulation Of Defense Response Regulation Of TRNA Methylation Negative Regulation Of Lung Blood Pressure Nuclear Mineralocorticoid Receptor Binding Protein N-acetylglucosaminyltransferase Complex Negative Regulation Of Non-canonical Inflammasome Complex Assembly Positive Regulation Of Late Endosome To Lysosome Transport Cellular Response To Glucose Stimulus TORC1 Signaling Negative Regulation Of Signal Transduction Apoptotic Mitochondrial Changes Positive Regulation Of TORC1 Signaling Protein Maturation Regulation Of Cell Adhesion
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