SNAPIN and LAMA2

Number of citations: 48 (PubMedID 23414517)
Data Source: BioGRID (two hybrid)

		SNAPIN	LAMA2
Name		SNAP associated protein	laminin subunit alpha 2
Structure		No pdb structure
GO Annotations	Cellular Component	Golgi Membrane Acrosomal Vesicle Manchette Cytoplasm Lysosome Lysosomal Membrane Golgi Apparatus Cytosol Synaptic Vesicle Membrane Secretory Granule Synaptic Vesicle Membrane BLOC-1 Complex Cytoplasmic Vesicle Synapse Perinuclear Region Of Cytoplasm Cytoplasmic Side Of Lysosomal Membrane BORC Complex Axon Cytoplasm Microvesicle	Extracellular Region Basement Membrane Extracellular Matrix Neuromuscular Junction Sarcolemma Synaptic Cleft Dendritic Spine Protein Complex Involved In Cell-matrix Adhesion
	Molecular Function	SNARE Binding Protein Binding	Signaling Receptor Binding Structural Molecule Activity Extracellular Matrix Structural Constituent
	Biological Process	Intracellular Protein Transport Exocytosis Lysosome Organization Lysosomal Lumen Acidification Chemical Synaptic Transmission Neurotransmitter Secretion Anterograde Axonal Transport Retrograde Axonal Transport Endosome To Lysosome Transport Negative Regulation Of Neuron Projection Development Synaptic Vesicle Exocytosis Synaptic Vesicle Maturation Neuron Projection Development Protein-containing Complex Localization Synaptic Vesicle Fusion To Presynaptic Active Zone Membrane Lysosome Localization Melanosome Organization Synaptic Vesicle Transport Anterograde Synaptic Vesicle Transport Regulation Of Endosome Size Protein Maturation Establishment Of Vesicle Localization Regulation Of Lysosome Size Neuron Cellular Homeostasis Organelle Transport Along Microtubule Terminal Button Organization Autophagosome Maturation Late Endosome To Lysosome Transport Positive Regulation Of Late Endosome To Lysosome Transport Regulation Of Synaptic Vesicle Exocytosis	Cell Adhesion Axon Guidance Muscle Organ Development Schwann Cell Differentiation Regulation Of Cell Adhesion Regulation Of Cell Migration Positive Regulation Of Synaptic Transmission, Cholinergic Maintenance Of Blood-brain Barrier Positive Regulation Of Cell Adhesion Regulation Of Embryonic Development Positive Regulation Of Muscle Cell Differentiation Regulation Of Basement Membrane Organization Positive Regulation Of Integrin-mediated Signaling Pathway
Pathways		Golgi Associated Vesicle Biogenesis	Laminin interactions Laminin interactions Non-integrin membrane-ECM interactions ECM proteoglycans MET activates PTK2 signaling EGR2 and SOX10-mediated initiation of Schwann cell myelination Attachment of bacteria to epithelial cells Formation of the dystrophin-glycoprotein complex (DGC) Formation of the dystrophin-glycoprotein complex (DGC) Developmental Lineage of Pancreatic Ductal Cells
Diseases		None	Congenital muscular dystrophies (CMD/MDC), including: Merosin-deficient CMD (MDC1A); Ullrich CMD (UCMD); Integrin alpha7-deficient CMD; CMD with joint hyperlaxity (CMDH); CMD with epidermolysis bullosa; Walker-Warburg syndrome (WWS); Muscle-eye-brain disease (MEB); Fukuyama CMD (FCMD); CMD with muscle hypertrophy (MDC1C); CMD with severe intellectual impairment and abnormal glycosylation (MDC1D); Rigid spine syndrome (RSS); LMNA-deficient CMD; CMD with respiratory failure and muscle hypertrophy (MDC1B); Bethlem myopathy
GWAS		No GWAS studies recorded	Amyotrophic lateral sclerosis (sporadic) ( 24529757 ) Appendicular lean mass ( 33097823 ) Axial length ( 24144296 ) Body mass index ( 20397748 ) Gut microbiota (bacterial taxa, rank normal transformation method) ( 32572223 ) Height ( 31562340 ) High myopia ( 33830181 31816047 ) Hyperopia ( 25233373 33830181 ) Low myopia vs hyperopia ( 33830181 ) Metabolite levels ( 23823483 ) Myopia ( 25233373 27182965 ) Night sleep phenotypes ( 27126917 ) Periodontal disease-related phenotype (Socransky) ( 24347629 ) Refractive error ( 23396134 ) Retinal detachment or retinal break ( 31816047 ) Serum bilirubin levels x Mediterranean diet adherence interaction in metabolic syndrome ( 30621171 ) Sleep duration (short sleep) ( 30846698 ) Smoking status (ever vs never smokers) ( 30643258 ) Spherical equivalent (joint analysis main effects and education interaction) ( 27020472 ) Spherical equivalent or myopia (age of diagnosis) ( 29808027 ) Tea consumption ( 31046077 )
Interacting Genes		103 interacting genes: ABI2 ACTN2 ATG14 ATP1A1 BANP BFSP1 BFSP2 BIN1 BLOC1S1 BLOC1S2 BLOC1S4 BLOC1S5 BLOC1S6 BNIPL C20orf202 CCDC102B CDC42BPA CEP170 CMYA5 CSNK1D DDR1 DENND1C DES DNM2 DOCK9 DST DTNBP1 DYRK3 DYSF EBAG9 EEF1G ELP1 ENO3 EXOC7 FAM114A1 FSD2 GPRASP1 GRIK1 HAP1 HMGB2 IKBIP IMMT KANK2 KAT5 KAT7 KIF5C KPNB1 KRT10 KRT15 KRT16 KRT17 KRT19 KRT20 KRT24 KRT26 LAMA2 LAMC1 LMNB1 LRP12 MACF1 MAPK14 MET MORC3 MTNR1A MYH14 MYH3 MYH7 NECAB2 NEDD9 NME7 NUP62CL PCYT1A PLAC9 PLEC PRKACA RABEP1 RABGEF1 RETREG1 RGS7 RNF13 SHBG SKA1 SMAD2 SMG1 SNAP23 SNAP25 SPAG5 SPP1 SPTB SPTBN1 ST7 TFIP11 TOMM70 TPM1 TPM2 TPM3 TPM4 TRIM63 TRPV1 TSG101 WASHC3 YWHAE YWHAZ	4 interacting genes: DAG1 RPSA SNAPIN TRIM63
Entrez ID		23557	3908
HPRD ID		06111	01125
Ensembl ID		ENSG00000143553	ENSG00000196569
Uniprot IDs		O95295	A0A087WYF1 P24043 Q59H37
PDB IDs		Not available	4YEP 4YEQ
GO Terms Enriched among Interactors		Cytoskeleton Organization Cytoskeleton Intermediate Filament Cytoskeleton Organization Intermediate Filament-based Process Organelle Organization Intermediate Filament Organization Establishment Of Organelle Localization Intermediate Filament Supramolecular Fiber Organization Organelle Localization Structural Constituent Of Cytoskeleton BLOC-1 Complex Actin Filament Binding Synaptic Vesicle Transport Establishment Of Vesicle Localization Structural Molecule Activity Axo-dendritic Transport Axon Cytoplasm Axonal Transport Vesicle Localization Establishment Of Localization In Cell Anterograde Axonal Transport Cytosol Anterograde Synaptic Vesicle Transport Muscle Thin Filament Tropomyosin Structural Constituent Of Skin Epidermis Cytoplasm Transport Along Microtubule Vesicle Transport Along Microtubule Cellular Localization Cytoskeleton-dependent Intracellular Transport Vesicle Cytoskeletal Trafficking Regulation Of Cellular Component Organization Microtubule-based Transport Melanosome Organization Keratin Filament Intracellular Transport Pigment Granule Organization Structural Constituent Of Muscle Actomyosin Structure Organization Muscle System Process Actin Binding Muscle Contraction Extracellular Exosome Contractile Muscle Fiber Stress Fiber Organelle Transport Along Microtubule Tissue Morphogenesis Intracellular Protein Localization Z Disc	Laminin Binding Muscle Attachment Symbiont Entry Into Host Cell Virus Receptor Activity Positive Regulation Of Late Endosome To Lysosome Transport Calcium-dependent Cell-matrix Adhesion Biological Process Involved In Interaction With Host Response To Electrical Stimulus Involved In Regulation Of Muscle Adaptation Retrograde Trans-synaptic Signaling By Trans-synaptic Protein Complex Nerve Maturation Developmental Maturation Protein Metabolic Process Laminin Receptor Activity Response To Denervation Involved In Regulation Of Muscle Adaptation Trans-synaptic Signaling By Trans-synaptic Complex Laminin-1 Binding Schwann Cell Differentiation Photoreceptor Ribbon Synapse Dystroglycan Complex Contractile Ring Terminal Button Organization Skeletal Muscle Atrophy Skeletal Muscle Adaptation Striated Muscle Atrophy Response To Muscle Inactivity Synaptic Vesicle Maturation Regulation Of Lysosome Size BORC Complex Microvesicle Muscle Atrophy Dystroglycan Binding Trans-synaptic Signaling Synaptic Vesicle Fusion To Presynaptic Active Zone Membrane Branching Involved In Salivary Gland Morphogenesis Costamere Vinculin Binding Cellular Response To Sterol Dystrophin-associated Glycoprotein Complex Neuron Projection Development Node Of Ranvier Schwann Cell Development Nuclear Periphery Skeletal Muscle Tissue Regeneration Regulation Of Neurotransmitter Receptor Localization To Postsynaptic Specialization Membrane Commissural Neuron Axon Guidance Angiogenesis Involved In Wound Healing Axon Regeneration Morphogenesis Of An Epithelial Sheet Positive Regulation Of Myelination Alpha-actinin Binding