DCTN2 and MARCKSL1

Number of citations of the paper that reports this interaction (PubMedID 10827182)
0

Data Source:
BioGRID (biochemical)
HPRD (in vitro, in vivo)

		DCTN2	MARCKSL1
Description		dynactin subunit 2	MARCKS like 1
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Kinetochore Cytoplasm Centrosome Cytosol Cytoskeleton Dynactin Complex Microtubule Membrane Dynein Complex Growth Cone Vesicle Extracellular Exosome	Cytoplasm Cytoskeleton Plasma Membrane Membrane Extracellular Exosome
	Molecular Function	Protein Binding Protein Kinase Binding Spectrin Binding Identical Protein Binding	Actin Binding Protein Binding Calmodulin Binding Actin Filament Binding
	Biological Process	Microtubule-based Process Mitotic Spindle Organization Mitotic Metaphase Chromosome Alignment Melanosome Transport Protein Localization To Centrosome	Actin Filament Organization Central Nervous System Development Cell Population Proliferation Positive Regulation Of Cell Population Proliferation
Pathways		MHC class II antigen presentation Regulation of PLK1 Activity at G2/M Transition HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand Loss of Nlp from mitotic centrosomes Recruitment of mitotic centrosome proteins and complexes Loss of proteins required for interphase microtubule organization from the centrosome Recruitment of NuMA to mitotic centrosomes Anchoring of the basal body to the plasma membrane COPI-mediated anterograde transport COPI-independent Golgi-to-ER retrograde traffic AURKA Activation by TPX2
Drugs
Diseases
GWAS		Brain morphology (MOSTest) ( 32665545)
Interacting Genes		39 interacting genes: ABI2 BICD1 BICD2 BLOC1S1 BLOC1S2 BLOC1S6 CALM1 CCDC172 CENPH CEP44 COG3 DISC1 EGFR FXR1 FXR2 GADD45A GADD45G GNAO1 GOLM1 GRB2 GSK3B HAUS1 HGS KIFC3 KPNA2 MAPK6 MAPRE3 MARCKSL1 OGT PAFAH1B1 RABGEF1 RINT1 RPGR SHANK3 SMARCD1 TSC1 TXLNB USHBP1 ZW10	3 interacting genes: BRCA1 CDC42 DCTN2
Entrez ID		10540	65108
HPRD ID		09568	04247
Ensembl ID		ENSG00000175203	ENSG00000175130
Uniprot IDs		A0A384MDU9 A8K8J9 B3KTX4 Q13561 V9HW58	P49006
PDB IDs
Enriched GO Terms of Interacting Partners?		Microtubule-based Process Organelle Organization Organelle Assembly Transport Along Microtubule Centrosome Cytoskeleton-dependent Intracellular Transport Cytoplasm Microtubule-based Transport Dynactin Binding Organelle Transport Along Microtubule Organelle Localization Cellular Localization Establishment Of Organelle Localization Regulation Of Dendritic Spine Development Membraneless Organelle Assembly Microtubule-based Movement Regulation Of Cytoskeleton Organization Microtubule Cytoskeleton Organization Intracellular Signal Transduction Positive Regulation Of Long-term Neuronal Synaptic Plasticity Protein Localization To Organelle Intracellular Transport Axo-dendritic Transport Cytosol Regulation Of Microtubule Cytoskeleton Organization Positive Regulation Of Dendritic Spine Development Cytoskeleton Regulation Of Dendritic Spine Morphogenesis Vesicle Transport Along Microtubule Intracellular Protein Localization Establishment Of Localization In Cell Retrograde Vesicle-mediated Transport, Golgi To Endoplasmic Reticulum BLOC-1 Complex Regulation Of Multicellular Organismal Process Anterograde Synaptic Vesicle Transport Regulation Of Organelle Organization Vesicle Cytoskeletal Trafficking Cytoskeleton Organization Positive Regulation Of Neurogenesis Axon Cytoplasm Modulation Of Chemical Synaptic Transmission Dynein Complex Binding Axonal Transport Central Region Of Growth Cone Regulation Of Translation At Presynapse, Modulating Synaptic Transmission Dsl1/NZR Complex Intracellular Signaling Cassette Cytoskeletal Anchor Activity Regulation Of Postsynapse Organization Regulation Of Microtubule-based Process	Negative Regulation Of Centrosome Duplication Negative Regulation Of Centriole Replication BRCA1-A Complex XY Body BRCA1-B Complex Regulation Of Cell Growth Histone H2AK127 Ubiquitin Ligase Activity Regulation Of Mitotic Cell Cycle Negative Regulation Of Gene Expression Via Chromosomal CpG Island Methylation Lateral Element Nuclear Ubiquitin Ligase Complex Cellular Response To Indole-3-methanol BRCA1-C Complex Ubiquitin Protein Ligase Activity Negative Regulation Of Intracellular Estrogen Receptor Signaling Pathway Gamma-tubulin Ring Complex Ubiquitin-modified Histone Reader Activity Histone H2AK129 Ubiquitin Ligase Activity Cellular Response To Cytokine Stimulus Response To Indole-3-methanol DNA Strand Resection Involved In Replication Fork Processing BRCA1-BARD1 Complex Identical Protein Binding DNA Repair Complex Random Inactivation Of X Chromosome Microtubule-based Process Leading Edge Membrane Positive Regulation Of Pseudopodium Assembly Endothelin Receptor Signaling Pathway Thioesterase Binding Organelle Localization Positive Regulation Of Pinocytosis Protein Kinase Binding Apolipoprotein A-I Receptor Binding Regulation Of Epithelial Cell Proliferation Involved In Lung Morphogenesis G Protein-coupled Receptor Signaling Pathway Involved In Heart Process Golgi Localization Endothelin Receptor Signaling Pathway Involved In Heart Process Neuron Fate Determination Cardiac Neural Crest Cell Migration Involved In Outflow Tract Morphogenesis Establishment Of Golgi Localization Establishment Of Organelle Localization Neuropilin Signaling Pathway GBD Domain Binding Golgi Transport Complex Storage Vacuole Positive Regulation Of Epithelial Cell Proliferation Involved In Lung Morphogenesis Dynactin Complex Regulation Of Cytoskeleton Organization Cardiac Conduction System Development
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