DCTN2 and MAPRE3

Number of citations of the paper that reports this interaction (PubMedID 27107012)
72

Data Source:
BioGRID (two hybrid)

		DCTN2	MAPRE3
Description		dynactin subunit 2	microtubule associated protein RP/EB family member 3
Image		No pdb structure
GO Annotations	Cellular Component	Kinetochore Cytoplasm Centrosome Cytosol Cytoskeleton Dynactin Complex Microtubule Membrane Dynein Complex Growth Cone Vesicle Extracellular Exosome	Cytoplasm Microtubule Organizing Center Cytoskeleton Microtubule Cytoplasmic Microtubule Microtubule Cytoskeleton Midbody Microtubule Plus-end Perinuclear Region Of Cytoplasm Spindle Midzone Neuron To Neuron Synapse Mitotic Spindle Astral Microtubule End Microtubule End
	Molecular Function	Protein Binding Protein Kinase Binding Spectrin Binding Identical Protein Binding	Protein Binding Microtubule Binding Identical Protein Binding Protein Serine/threonine Kinase Activator Activity Microtubule Plus-end Binding Protein Serine/threonine Kinase Binding
	Biological Process	Microtubule-based Process Mitotic Spindle Organization Mitotic Metaphase Chromosome Alignment Melanosome Transport Protein Localization To Centrosome	Intracellular Protein Localization Regulation Of Microtubule Polymerization Or Depolymerization Regulation Of Microtubule Polymerization Protein Localization To Microtubule Positive Regulation Of DNA-templated Transcription Behavioral Response To Cocaine Spindle Assembly Cell Division Positive Regulation Of Dendritic Spine Morphogenesis
Pathways		MHC class II antigen presentation Regulation of PLK1 Activity at G2/M Transition HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand Loss of Nlp from mitotic centrosomes Recruitment of mitotic centrosome proteins and complexes Loss of proteins required for interphase microtubule organization from the centrosome Recruitment of NuMA to mitotic centrosomes Anchoring of the basal body to the plasma membrane COPI-mediated anterograde transport COPI-independent Golgi-to-ER retrograde traffic AURKA Activation by TPX2
Drugs
Diseases
GWAS		Brain morphology (MOSTest) ( 32665545)	Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Cortical surface area (min-P) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Cortical thickness (MOSTest) ( 32665545) Estimated glomerular filtration rate in non-diabetics ( 31451708) Left–right brain asymmetry ( 33723403) Lymphocyte percentage of white cells ( 32888494) Neutrophil count ( 32888494) Neutrophil percentage of white cells ( 32888494) Post bronchodilator FEV1/FVC ratio ( 26634245) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545)
Interacting Genes		39 interacting genes: ABI2 BICD1 BICD2 BLOC1S1 BLOC1S2 BLOC1S6 CALM1 CCDC172 CENPH CEP44 COG3 DISC1 EGFR FXR1 FXR2 GADD45A GADD45G GNAO1 GOLM1 GRB2 GSK3B HAUS1 HGS KIFC3 KPNA2 MAPK6 MAPRE3 MARCKSL1 OGT PAFAH1B1 RABGEF1 RINT1 RPGR SHANK3 SMARCD1 TSC1 TXLNB USHBP1 ZW10	56 interacting genes: ANKRD1 APC2 AURKA AURKB C20orf202 CCSER1 CHRDL2 CLASP1 CRTAC1 DCTN2 DDIT4L DOK4 EIF4E2 FAM161B FOXD4L1 FOXD4L4 FXR2 GTF2F2 GTSE1 HROB IKZF1 JUN KIF19 KLHDC7B KNSTRN LAP3 LHX4 LMO2 MAPRE2 MARCHF7 MEOX2 MRPL12 PDE4DIP PICK1 POU4F1 PSMA1 PSMB1 PSRC1 RAB1A REL SDCBP SIAH1 SLAIN1 SPDYE2 SPDYE2B SPMIP10 SPMIP2 TLE5 TRAIP TRIM14 TXN2 YAF2 ZC2HC1A ZC2HC1C ZNF526 ZNF547
Entrez ID		10540	22924
HPRD ID		09568	16156
Ensembl ID		ENSG00000175203	ENSG00000084764
Uniprot IDs		A0A384MDU9 A8K8J9 B3KTX4 Q13561 V9HW58	Q9UPY8
PDB IDs			1WYO 3CO1 3JAK 3JAL 3JAR 3TQ7 7SJ9
Enriched GO Terms of Interacting Partners?		Microtubule-based Process Organelle Organization Organelle Assembly Transport Along Microtubule Centrosome Cytoskeleton-dependent Intracellular Transport Cytoplasm Microtubule-based Transport Dynactin Binding Organelle Transport Along Microtubule Organelle Localization Cellular Localization Establishment Of Organelle Localization Regulation Of Dendritic Spine Development Membraneless Organelle Assembly Microtubule-based Movement Regulation Of Cytoskeleton Organization Microtubule Cytoskeleton Organization Intracellular Signal Transduction Positive Regulation Of Long-term Neuronal Synaptic Plasticity Protein Localization To Organelle Intracellular Transport Axo-dendritic Transport Cytosol Regulation Of Microtubule Cytoskeleton Organization Positive Regulation Of Dendritic Spine Development Cytoskeleton Regulation Of Dendritic Spine Morphogenesis Vesicle Transport Along Microtubule Intracellular Protein Localization Establishment Of Localization In Cell Retrograde Vesicle-mediated Transport, Golgi To Endoplasmic Reticulum BLOC-1 Complex Regulation Of Multicellular Organismal Process Anterograde Synaptic Vesicle Transport Regulation Of Organelle Organization Vesicle Cytoskeletal Trafficking Cytoskeleton Organization Positive Regulation Of Neurogenesis Axon Cytoplasm Modulation Of Chemical Synaptic Transmission Dynein Complex Binding Axonal Transport Central Region Of Growth Cone Regulation Of Translation At Presynapse, Modulating Synaptic Transmission Dsl1/NZR Complex Intracellular Signaling Cassette Cytoskeletal Anchor Activity Regulation Of Postsynapse Organization Regulation Of Microtubule-based Process	Regulation Of Microtubule Polymerization Or Depolymerization Microtubule-based Process Microtubule Cytoskeleton Organization Spindle Organization Regulation Of Microtubule Cytoskeleton Organization Cytoplasmic Microtubule Microtubule Plus-end Microtubule Cytoskeleton Regulation Of Microtubule-based Process Positive Regulation Of Microtubule Polymerization Cytoskeleton Spindle Microtubule Cytoskeleton Organization Microtubule Microtubule Organizing Center Plasma Membrane Bounded Cell Projection Organization Microtubule Plus-end Binding Cytoplasmic Microtubule Organization Regulation Of Microtubule Polymerization Spindle Midzone Protein Binding Cell Projection Organization Chromosome Passenger Complex Positive Regulation Of Protein Polymerization Microtubule Binding Kinetochore Mitotic Spindle Organization Spindle Assembly Positive Regulation Of Supramolecular Fiber Organization Regulation Of Microtubule Depolymerization Regulation Of Supramolecular Fiber Organization Regulation Of Cytoskeleton Organization Positive Regulation Of Cytoskeleton Organization Positive Regulation Of Epithelial Cell Migration Cilium Disassembly Protein Localization To Cytoskeleton Astral Microtubule Organization Beta-catenin Destruction Complex Regulation Of Signal Transduction By P53 Class Mediator Microtubule Cytoskeleton Organization Involved In Mitosis Negative Regulation Of Interferon-beta Production Positive Regulation Of Organelle Organization Regulation Of Organelle Organization Regulation Of Epithelial Cell Migration
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