DCTN2 and TXLNB

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		DCTN2	TXLNB
Description		dynactin subunit 2	taxilin beta
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Kinetochore Cytoplasm Centrosome Cytosol Cytoskeleton Dynactin Complex Microtubule Membrane Dynein Complex Growth Cone Vesicle Extracellular Exosome	Cytoplasm
	Molecular Function	Protein Binding Protein Kinase Binding Spectrin Binding Identical Protein Binding	Protein Binding Syntaxin Binding
	Biological Process	Microtubule-based Process Mitotic Spindle Organization Mitotic Metaphase Chromosome Alignment Melanosome Transport Protein Localization To Centrosome
Pathways		MHC class II antigen presentation Regulation of PLK1 Activity at G2/M Transition HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand Loss of Nlp from mitotic centrosomes Recruitment of mitotic centrosome proteins and complexes Loss of proteins required for interphase microtubule organization from the centrosome Recruitment of NuMA to mitotic centrosomes Anchoring of the basal body to the plasma membrane COPI-mediated anterograde transport COPI-independent Golgi-to-ER retrograde traffic AURKA Activation by TPX2
Drugs
Diseases
GWAS		Brain morphology (MOSTest) ( 32665545)	Albumin-globulin ratio ( 29403010) Caudate volume in trauma-exposed individuals ( 29187748) Heel bone mineral density ( 30598549) Non-albumin protein levels ( 29403010) Waist-to-hip ratio adjusted for BMI ( 26426971) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971)
Interacting Genes		39 interacting genes: ABI2 BICD1 BICD2 BLOC1S1 BLOC1S2 BLOC1S6 CALM1 CCDC172 CENPH CEP44 COG3 DISC1 EGFR FXR1 FXR2 GADD45A GADD45G GNAO1 GOLM1 GRB2 GSK3B HAUS1 HGS KIFC3 KPNA2 MAPK6 MAPRE3 MARCKSL1 OGT PAFAH1B1 RABGEF1 RINT1 RPGR SHANK3 SMARCD1 TSC1 TXLNB USHBP1 ZW10	67 interacting genes: AXIN2 BTF3 BTF3L4 C18orf54 CAGE1 CBY2 CCDC13 CCDC14 CCDC152 CCDC196 CCDC88B CCHCR1 CDR2 CEP19 CEP57 CEP57L1 CEP70 CFAP53 CT55 DCTN2 DEUP1 DMAP1 DRC4 DYDC1 EXOC5 FAM161A FAM167A GOLGA2 HAUS3 KIAA1328 KRT13 KRT15 KRT16 KRT26 KRT27 KRT34 KRT35 KRT37 KRT38 KRT39 KRT6A KRT75 LPXN LZTS1 MBIP MEOX2 MNS1 NEFL NF2 NMI ODAD3 SIKE1 SNAPC5 SOX13 STMN3 STX1A STX4 TADA3 TCL1A TXLNA UBE2I USHBP1 UTP14A VIM VPS52 WASHC3 ZNF20
Entrez ID		10540	167838
HPRD ID		09568	10793
Ensembl ID		ENSG00000175203	ENSG00000164440
Uniprot IDs		A0A384MDU9 A8K8J9 B3KTX4 Q13561 V9HW58	Q8N3L3
PDB IDs
Enriched GO Terms of Interacting Partners?		Microtubule-based Process Organelle Organization Organelle Assembly Transport Along Microtubule Centrosome Cytoskeleton-dependent Intracellular Transport Cytoplasm Microtubule-based Transport Dynactin Binding Organelle Transport Along Microtubule Organelle Localization Cellular Localization Establishment Of Organelle Localization Regulation Of Dendritic Spine Development Membraneless Organelle Assembly Microtubule-based Movement Regulation Of Cytoskeleton Organization Microtubule Cytoskeleton Organization Intracellular Signal Transduction Positive Regulation Of Long-term Neuronal Synaptic Plasticity Protein Localization To Organelle Intracellular Transport Axo-dendritic Transport Cytosol Regulation Of Microtubule Cytoskeleton Organization Positive Regulation Of Dendritic Spine Development Cytoskeleton Regulation Of Dendritic Spine Morphogenesis Vesicle Transport Along Microtubule Intracellular Protein Localization Establishment Of Localization In Cell Retrograde Vesicle-mediated Transport, Golgi To Endoplasmic Reticulum BLOC-1 Complex Regulation Of Multicellular Organismal Process Anterograde Synaptic Vesicle Transport Regulation Of Organelle Organization Vesicle Cytoskeletal Trafficking Cytoskeleton Organization Positive Regulation Of Neurogenesis Axon Cytoplasm Modulation Of Chemical Synaptic Transmission Dynein Complex Binding Axonal Transport Central Region Of Growth Cone Regulation Of Translation At Presynapse, Modulating Synaptic Transmission Dsl1/NZR Complex Intracellular Signaling Cassette Cytoskeletal Anchor Activity Regulation Of Postsynapse Organization Regulation Of Microtubule-based Process	Intermediate Filament Organization Intermediate Filament Cytoskeleton Organization Intermediate Filament-based Process Structural Constituent Of Skin Epidermis Intermediate Filament Keratin Filament Cytoskeleton Cytoskeleton Organization Supramolecular Fiber Organization Organelle Organization Structural Molecule Activity Epithelial Cell Differentiation Morphogenesis Of An Epithelium Cytosol Tissue Morphogenesis Protein Binding Microtubule Cytoskeleton Organization Microtubule-based Process Cell Projection Cilium Organization Anatomical Structure Morphogenesis Centrosome Centriole Structural Constituent Of Cytoskeleton Cilium Sperm Flagellum Mitotic Spindle Ciliary Basal Body Gamma-tubulin Binding Polymeric Cytoskeletal Fiber Identical Protein Binding Microtubule Binding Cell Differentiation Plasma Membrane Bounded Cell Projection Organization Microtubule Organizing Center Cilium Assembly Schaffer Collateral - CA1 Synapse Epithelial Cilium Movement Involved In Extracellular Fluid Movement Osteoblast Proliferation Extracellular Transport Syntaxin Binding Intermediate Filament Cytoskeleton Cell Projection Organization SNARE Complex Assembly Flagellated Sperm Motility Negative Regulation Of Osteoblast Proliferation Epithelial Cilium Movement Involved In Determination Of Left/right Asymmetry Sperm Motility Exocytosis Axoneme
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