DCTN2 and BICD1

Number of citations of the paper that reports this interaction (PMID 17139249)
25

Data Source:
HPRD (in vivo)

		DCTN2	BICD1
Gene Name		dynactin 2 (p50)	bicaudal D homolog 1 (Drosophila)
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Kinetochore Cytoplasm Centrosome Cytosol Dynactin Complex Microtubule Membrane Dynein Complex Growth Cone Vesicle Extracellular Vesicular Exosome	Golgi Apparatus Trans-Golgi Network Cytosol Cytoskeleton Cytoplasmic Microtubule Membrane Cytoplasmic Vesicle Tubulin Complex Perinuclear Region Of Cytoplasm Host Cell Viral Assembly Compartment
	Molecular Function	Motor Activity Protein Binding Spectrin Binding	Structural Constituent Of Cytoskeleton Protein Binding Cytoskeletal Adaptor Activity Rab GTPase Binding Proteinase Activated Receptor Binding Dynactin Binding Dynein Binding
	Biological Process	G2/M Transition Of Mitotic Cell Cycle Mitotic Cell Cycle Organelle Organization Mitotic Spindle Organization Mitotic Nuclear Division Metabolic Process Cell Proliferation Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II Melanosome Transport	RNA Processing Intracellular MRNA Localization Anatomical Structure Morphogenesis Viral Process Protein Localization To Organelle Stress Granule Assembly Positive Regulation Of Receptor-mediated Endocytosis Minus-end-directed Organelle Transport Along Microtubule Microtubule Anchoring At Microtubule Organizing Center Negative Regulation Of Phospholipase C Activity Regulation Of Proteinase Activated Receptor Activity Negative Regulation Of Phospholipase C-activating G-protein Coupled Receptor Signaling Pathway
Pathways		Organelle biogenesis and maintenance Assembly of the primary cilium G2/M Transition Anchoring of the basal body to the plasma membrane Regulation of PLK1 Activity at G2/M Transition Cell Cycle, Mitotic Loss of proteins required for interphase microtubule organizationÂ from the centrosome Loss of Nlp from mitotic centrosomes MHC class II antigen presentation Centrosome maturation Mitotic G2-G2/M phases Recruitment of mitotic centrosome proteins and complexes Adaptive Immune System
Drugs
Diseases
GWAS			Emphysema-related traits ( 20709820) Normalized brain volume ( 19010793) Obesity-related traits ( 23251661) Pancreatic cancer ( 20686608)
Protein-Protein Interactions		21 interactors: BICD1 BICD2 BLOC1S6 CALM1 CCDC172 DISC1 EGFR GADD45A GNAO1 GOLM1 GRB2 GSK3B HAUS1 HGS KIFC3 KPNA2 MAPK6 MARCKSL1 PAFAH1B1 RPGR ZW10	12 interactors: ALPI CPNE4 DCTN1 DCTN2 DISC1 DYNC1I1 GSK3A GSK3B MAPK14 NIN RAB6A STAT3
Entrez ID		10540	636
HPRD ID		09568	03730
Ensembl ID		ENSG00000175203	ENSG00000151746
Uniprot IDs		Q13561	A8MVZ6 Q96G01
PDB IDs
Enriched GO Terms of Interacting Partners?		Microtubule-based Process Microtubule Cytoskeleton Organization Cellular Localization Microtubule-based Transport Protein Localization Cytoskeleton-dependent Intracellular Transport Movement Of Cell Or Subcellular Component Microtubule-based Movement Epidermal Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Cellular Protein Localization Organelle Organization Establishment Of Localization In Cell Intracellular Transport Minus-end-directed Organelle Transport Along Microtubule Negative Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Neuron Development Cerebral Cortex Development Negative Regulation Of ERBB Signaling Pathway Fibroblast Growth Factor Receptor Signaling Pathway Establishment Of Protein Localization Organelle Transport Along Microtubule Cellular Response To Fibroblast Growth Factor Stimulus Response To Fibroblast Growth Factor Generation Of Neurons Neuron Differentiation Cytoskeleton Organization Pallium Development Forebrain Development Cell Projection Organization Neurotrophin TRK Receptor Signaling Pathway Brain Development Cellular Response To Mechanical Stimulus Neurogenesis Neurotrophin Signaling Pathway Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Fc-epsilon Receptor Signaling Pathway Head Development Neuron Projection Development Nervous System Development Regulation Of ERBB Signaling Pathway Microtubule Anchoring At Microtubule Organizing Center Positive Regulation Of Reactive Oxygen Species Metabolic Process Regulation Of Phospholipase Activity Protein Localization To Organelle Cerebral Cortex Cell Migration Fc Receptor Signaling Pathway Cell Cycle Telencephalon Cell Migration Telencephalon Development	Movement Of Cell Or Subcellular Component Negative Regulation Of Type B Pancreatic Cell Development Microtubule-based Process Hypermethylation Of CpG Island Cellular Localization Cellular Response To Interleukin-3 Neurotrophin TRK Receptor Signaling Pathway Neurotrophin Signaling Pathway Negative Regulation Of Glycogen (starch) Synthase Activity Regulation Of Generation Of Precursor Metabolites And Energy Antigen Processing And Presentation Regulation Of Wnt Signaling Pathway Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II Antigen Processing And Presentation Of Peptide Antigen Via MHC Class II Negative Regulation Of Cardiac Muscle Hypertrophy Negative Regulation Of Glycogen Biosynthetic Process Negative Regulation Of Muscle Hypertrophy Regulation Of Glycogen (starch) Synthase Activity Immune System Process Antigen Processing And Presentation Of Peptide Or Polysaccharide Antigen Via MHC Class II ER-nucleus Signaling Pathway Regulation Of Type B Pancreatic Cell Development Positive Regulation Of Peptidyl-threonine Phosphorylation Microtubule-based Transport Organelle Localization Cytoskeleton-dependent Intracellular Transport Positive Regulation Of Protein Modification Process Negative Regulation Of Canonical Wnt Signaling Pathway Regulation Of DNA Methylation Regulation Of Carbohydrate Metabolic Process Response To Endoplasmic Reticulum Stress Intracellular Signal Transduction Regulation Of Gene Expression By Genetic Imprinting Positive Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Positive Regulation Of Cellular Protein Metabolic Process Regulation Of Cardiac Muscle Hypertrophy Response To Lithium Ion Negative Regulation Of Wnt Signaling Pathway Establishment Of Vesicle Localization Melanosome Transport Regulation Of Glycogen Biosynthetic Process Pigment Granule Transport Cellular Response To Growth Factor Stimulus Vesicle Localization Establishment Of Melanosome Localization Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Establishment Of Localization In Cell Response To Growth Factor Genetic Imprinting Negative Regulation Of Epithelial Cell Differentiation
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