DCTN2 and BICD1

Number of citations of the paper that reports this interaction (PubMedID 17139249)
35

Data Source:
HPRD (in vivo)

		DCTN2	BICD1
Description		dynactin subunit 2	BICD cargo adaptor 1
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Kinetochore Cytoplasm Centrosome Cytosol Cytoskeleton Dynactin Complex Microtubule Membrane Dynein Complex Growth Cone Vesicle Extracellular Exosome	Golgi Apparatus Trans-Golgi Network Centrosome Cytosol Cytoskeleton Cytoplasmic Microtubule Membrane Cytoplasmic Vesicle Perinuclear Region Of Cytoplasm Secretory Vesicle
	Molecular Function	Protein Binding Protein Kinase Binding Spectrin Binding Identical Protein Binding	Structural Constituent Of Cytoskeleton Protein Binding Cytoskeletal Anchor Activity Protein Kinase Binding Small GTPase Binding Proteinase Activated Receptor Binding Dynactin Binding Dynein Intermediate Chain Binding Dynein Complex Binding
	Biological Process	Microtubule-based Process Mitotic Spindle Organization Mitotic Metaphase Chromosome Alignment Melanosome Transport Protein Localization To Centrosome	RNA Processing Intracellular MRNA Localization Anatomical Structure Morphogenesis Virion Assembly Protein Localization To Organelle Stress Granule Assembly Constitutive Secretory Pathway Positive Regulation Of Receptor-mediated Endocytosis Regulation Of Microtubule Cytoskeleton Organization Minus-end-directed Organelle Transport Along Microtubule Microtubule Anchoring At Microtubule Organizing Center Negative Regulation Of Phospholipase C-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Protein Localization To Centrosome
Pathways		MHC class II antigen presentation Regulation of PLK1 Activity at G2/M Transition HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand Loss of Nlp from mitotic centrosomes Recruitment of mitotic centrosome proteins and complexes Loss of proteins required for interphase microtubule organization from the centrosome Recruitment of NuMA to mitotic centrosomes Anchoring of the basal body to the plasma membrane COPI-mediated anterograde transport COPI-independent Golgi-to-ER retrograde traffic AURKA Activation by TPX2	COPI-independent Golgi-to-ER retrograde traffic
Drugs
Diseases
GWAS		Brain morphology (MOSTest) ( 32665545)	Emphysema-related traits ( 20709820) Fourth ventricle volume ( 31530798) Intralaminar thalamic nuclei volume ( 34006833) Left ventricular mass x antihypertensive treatment interaction ( 31407531) Normalized brain volume ( 19010793) Obesity-related traits ( 23251661) Pancreatic cancer ( 20686608) Parkinson's disease ( 32201043)
Interacting Genes		39 interacting genes: ABI2 BICD1 BICD2 BLOC1S1 BLOC1S2 BLOC1S6 CALM1 CCDC172 CENPH CEP44 COG3 DISC1 EGFR FXR1 FXR2 GADD45A GADD45G GNAO1 GOLM1 GRB2 GSK3B HAUS1 HGS KIFC3 KPNA2 MAPK6 MAPRE3 MARCKSL1 OGT PAFAH1B1 RABGEF1 RINT1 RPGR SHANK3 SMARCD1 TSC1 TXLNB USHBP1 ZW10	15 interacting genes: ALPI CPNE4 DCTN1 DCTN2 DISC1 DSCAM DYNC1I1 FXR1 GSK3A GSK3B MAPK14 NIN PTPN23 RAB6A STAT3
Entrez ID		10540	636
HPRD ID		09568	03730
Ensembl ID		ENSG00000175203	ENSG00000151746
Uniprot IDs		A0A384MDU9 A8K8J9 B3KTX4 Q13561 V9HW58	A8MVZ6 F8VZX7 Q96G01
PDB IDs
Enriched GO Terms of Interacting Partners?		Microtubule-based Process Organelle Organization Organelle Assembly Transport Along Microtubule Centrosome Cytoskeleton-dependent Intracellular Transport Cytoplasm Microtubule-based Transport Dynactin Binding Organelle Transport Along Microtubule Organelle Localization Cellular Localization Establishment Of Organelle Localization Regulation Of Dendritic Spine Development Membraneless Organelle Assembly Microtubule-based Movement Regulation Of Cytoskeleton Organization Microtubule Cytoskeleton Organization Intracellular Signal Transduction Positive Regulation Of Long-term Neuronal Synaptic Plasticity Protein Localization To Organelle Intracellular Transport Axo-dendritic Transport Cytosol Regulation Of Microtubule Cytoskeleton Organization Positive Regulation Of Dendritic Spine Development Cytoskeleton Regulation Of Dendritic Spine Morphogenesis Vesicle Transport Along Microtubule Intracellular Protein Localization Establishment Of Localization In Cell Retrograde Vesicle-mediated Transport, Golgi To Endoplasmic Reticulum BLOC-1 Complex Regulation Of Multicellular Organismal Process Anterograde Synaptic Vesicle Transport Regulation Of Organelle Organization Vesicle Cytoskeletal Trafficking Cytoskeleton Organization Positive Regulation Of Neurogenesis Axon Cytoplasm Modulation Of Chemical Synaptic Transmission Dynein Complex Binding Axonal Transport Central Region Of Growth Cone Regulation Of Translation At Presynapse, Modulating Synaptic Transmission Dsl1/NZR Complex Intracellular Signaling Cassette Cytoskeletal Anchor Activity Regulation Of Postsynapse Organization Regulation Of Microtubule-based Process	Axon Dynein Complex Positive Regulation Of Cellular Component Organization Regulation Of Cell Development Regulation Of Developmental Growth Negative Regulation Of Type B Pancreatic Cell Development Negative Regulation Of Glycogen (starch) Synthase Activity Positive Regulation Of Cell Differentiation Glutamatergic Synapse Ciliary Basal Body Nervous System Development Regulation Of Glycogen (starch) Synthase Activity Regulation Of Growth Tau Protein Binding Regulation Of Axonogenesis Beta-arrestin-dependent Dopamine Receptor Signaling Pathway Microtubule Spindle Pole Negative Regulation Of Catabolic Process Regulation Of Cell Differentiation Cell Projection Organization Cellular Response To Interleukin-3 Regulation Of Mitochondrial Membrane Permeability Regulation Of Type B Pancreatic Cell Development Centriolar Subdistal Appendage Regulation Of Neuron Projection Development Negative Regulation Of Glycogen Biosynthetic Process Positive Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Regulation Of Membrane Permeability Protein Kinase Binding Regulation Of Cell Adhesion Microtubule Anchoring At Centrosome Microtubule-based Process Positive Regulation Of Neurogenesis Positive Regulation Of Axonogenesis Regulation Of Axon Extension Beta-catenin Destruction Complex Centriole-centriole Cohesion Microtubule Anchoring At Microtubule Organizing Center Plasma Membrane Bounded Cell Projection Organization Regulation Of Cellular Component Organization Positive Regulation Of Developmental Process Protein Kinase A Catalytic Subunit Binding Establishment Of Organelle Localization Organelle Organization Camera-type Eye Photoreceptor Cell Differentiation Positive Regulation Of Nervous System Development Positive Regulation Of Catabolic Process Regulation Of Multicellular Organismal Development Establishment Of Vesicle Localization
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