DCTN2 and GNAO1

Number of citations of the paper that reports this interaction (PMID 16169070)
531

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		DCTN2	GNAO1
Gene Name		dynactin 2 (p50)	guanine nucleotide binding protein (G protein), alpha activating activity polypeptide O
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Kinetochore Cytoplasm Centrosome Cytosol Dynactin Complex Microtubule Membrane Dynein Complex Growth Cone Vesicle Extracellular Vesicular Exosome	Heterotrimeric G-protein Complex Plasma Membrane Neuron Projection
	Molecular Function	Motor Activity Protein Binding Spectrin Binding	GTPase Activity Signal Transducer Activity GTP Binding G-protein Beta/gamma-subunit Complex Binding G-protein Coupled Serotonin Receptor Binding Mu-type Opioid Receptor Binding GTPase Activating Protein Binding Metal Ion Binding Corticotropin-releasing Hormone Receptor 1 Binding
	Biological Process	G2/M Transition Of Mitotic Cell Cycle Mitotic Cell Cycle Organelle Organization Mitotic Spindle Organization Mitotic Nuclear Division Metabolic Process Cell Proliferation Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II Melanosome Transport	Muscle Contraction Adenylate Cyclase-modulating G-protein Coupled Receptor Signaling Pathway Dopamine Receptor Signaling Pathway Aging Locomotory Behavior Regulation Of Heart Contraction Forebrain Development Neuron Projection Development Response To Cytokine Response To Drug Response To Hydrogen Peroxide Response To Morphine Positive Regulation Of GTPase Activity Negative Regulation Of Calcium Ion Transport
Pathways		Organelle biogenesis and maintenance Assembly of the primary cilium G2/M Transition Anchoring of the basal body to the plasma membrane Regulation of PLK1 Activity at G2/M Transition Cell Cycle, Mitotic Loss of proteins required for interphase microtubule organizationÂ from the centrosome Loss of Nlp from mitotic centrosomes MHC class II antigen presentation Centrosome maturation Mitotic G2-G2/M phases Recruitment of mitotic centrosome proteins and complexes Adaptive Immune System	Signaling by GPCR Ca2+ pathway PLC beta mediated events G-protein activation Opioid Signalling Signaling by Wnt G-protein mediated events beta-catenin independent WNT signaling
Drugs
Diseases
GWAS
Protein-Protein Interactions		21 interactors: BICD1 BICD2 BLOC1S6 CALM1 CCDC172 DISC1 EGFR GADD45A GNAO1 GOLM1 GRB2 GSK3B HAUS1 HGS KIFC3 KPNA2 MAPK6 MARCKSL1 PAFAH1B1 RPGR ZW10	34 interactors: ADORA1 ADRA2A ADRA2C CACNA1B CCR5 CRHR1 DCTN2 FFAR2 GABBR1 GNAI1 GPSM2 GRM6 HRH4 KLHL3 NGB NUCB1 OPRD1 OPRM1 PDE6G PDE6H PTPRU RGS1 RGS10 RGS14 RGS16 RGS19 RGS20 RGS4 RGS5 RGS7 RIC8A S1PR5 SCN8A TSHR
Entrez ID		10540	2775
HPRD ID		09568	00757
Ensembl ID		ENSG00000175203	ENSG00000087258
Uniprot IDs		Q13561	B3KP89 P09471 Q6AWC5 Q8N6I9
PDB IDs
Enriched GO Terms of Interacting Partners?		Microtubule-based Process Microtubule Cytoskeleton Organization Cellular Localization Microtubule-based Transport Protein Localization Cytoskeleton-dependent Intracellular Transport Movement Of Cell Or Subcellular Component Microtubule-based Movement Epidermal Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Cellular Protein Localization Organelle Organization Establishment Of Localization In Cell Intracellular Transport Minus-end-directed Organelle Transport Along Microtubule Negative Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Neuron Development Cerebral Cortex Development Negative Regulation Of ERBB Signaling Pathway Fibroblast Growth Factor Receptor Signaling Pathway Establishment Of Protein Localization Organelle Transport Along Microtubule Cellular Response To Fibroblast Growth Factor Stimulus Response To Fibroblast Growth Factor Generation Of Neurons Neuron Differentiation Cytoskeleton Organization Pallium Development Forebrain Development Cell Projection Organization Neurotrophin TRK Receptor Signaling Pathway Brain Development Cellular Response To Mechanical Stimulus Neurogenesis Neurotrophin Signaling Pathway Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Fc-epsilon Receptor Signaling Pathway Head Development Neuron Projection Development Nervous System Development Regulation Of ERBB Signaling Pathway Microtubule Anchoring At Microtubule Organizing Center Positive Regulation Of Reactive Oxygen Species Metabolic Process Regulation Of Phospholipase Activity Protein Localization To Organelle Cerebral Cortex Cell Migration Fc Receptor Signaling Pathway Cell Cycle Telencephalon Cell Migration Telencephalon Development	Regulation Of G-protein Coupled Receptor Protein Signaling Pathway G-protein Coupled Receptor Signaling Pathway Adenylate Cyclase-modulating G-protein Coupled Receptor Signaling Pathway Negative Regulation Of G-protein Coupled Receptor Protein Signaling Pathway G-protein Coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Adenylate Cyclase-inhibiting G-protein Coupled Receptor Signaling Pathway Termination Of G-protein Coupled Receptor Signaling Pathway Termination Of Signal Transduction Cell Surface Receptor Signaling Pathway Regulation Of Catalytic Activity Positive Regulation Of Catalytic Activity Positive Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Negative Regulation Of Signaling Regulation Of Signaling Positive Regulation Of ERBB Signaling Pathway Signaling Cell Communication Signal Transduction Cell-cell Signaling Neurological System Process Regulation Of Signal Transduction Locomotory Behavior Positive Regulation Of GTPase Activity Negative Regulation Of Epinephrine Secretion Regulation Of Sensory Perception Of Pain Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Regulation Of GTPase Activity Positive Regulation Of Metabolic Process Behavior Regulation Of ERBB Signaling Pathway Regulation Of MAPK Cascade Negative Regulation Of Signal Transduction Response To Stimulus Regulation Of Phosphorus Metabolic Process Positive Regulation Of Epidermal Growth Factor-activated Receptor Activity Cellular Response To Stimulus Regulation Of Cellular Process Positive Regulation Of Hydrolase Activity Sensory Perception Regulation Of Neurological System Process Regulation Of Adenylate Cyclase Activity Negative Regulation Of Smooth Muscle Contraction Regulation Of Ion Transport Phospholipase C-activating G-protein Coupled Receptor Signaling Pathway Negative Regulation Of Hormone Secretion Negative Regulation Of Uterine Smooth Muscle Contraction Regulation Of Cyclase Activity Single-organism Behavior Regulation Of MAP Kinase Activity Negative Regulation Of Secretion By Cell
Tagcloud ?			aberrations assessing associations catenin clinicopathological egfr gnai2 gnaq gnas grades impacts intraductal ipmn ipmns kras morphological mucinous mutations neoplasm overexpression pakt pancreas papillary phenotypes pik3ca pmapk retrospectively smad4 tp53
Tagcloud (Difference) ?			aberrations assessing associations catenin clinicopathological egfr gnai2 gnaq gnas grades impacts intraductal ipmn ipmns kras morphological mucinous mutations neoplasm overexpression pakt pancreas papillary phenotypes pik3ca pmapk retrospectively smad4 tp53
Tagcloud (Intersection) ?