DCTN2 and ZW10

Number of citations of the paper that reports this interaction (PubMedID 9700164)
53

Data Source:
HPRD (two hybrid)

		DCTN2	ZW10
Description		dynactin subunit 2	zw10 kinetochore protein
Image		No pdb structure
GO Annotations	Cellular Component	Kinetochore Cytoplasm Centrosome Cytosol Cytoskeleton Dynactin Complex Microtubule Membrane Dynein Complex Growth Cone Vesicle Extracellular Exosome	Chromosome, Centromeric Region Kinetochore Spindle Pole Nucleus Chromosome Cytoplasm Endoplasmic Reticulum Endoplasmic Reticulum Membrane Lipid Droplet Spindle Kinetochore Microtubule Cytosol Cytoskeleton Membrane Dsl1/NZR Complex RZZ Complex
	Molecular Function	Protein Binding Protein Kinase Binding Spectrin Binding Identical Protein Binding	Protein Binding Centromeric DNA Binding
	Biological Process	Microtubule-based Process Mitotic Spindle Organization Mitotic Metaphase Chromosome Alignment Melanosome Transport Protein Localization To Centrosome	Mitotic Sister Chromatid Segregation Establishment Of Mitotic Spindle Orientation Mitotic Cell Cycle Endoplasmic Reticulum To Golgi Vesicle-mediated Transport Retrograde Vesicle-mediated Transport, Golgi To Endoplasmic Reticulum Golgi Organization Mitotic Metaphase Chromosome Alignment Mitotic Spindle Assembly Checkpoint Signaling Regulation Of Exit From Mitosis Protein Transport Vesicle-mediated Transport Protein Localization To Kinetochore Cell Division Meiotic Cell Cycle Regulation Of Attachment Of Spindle Microtubules To Kinetochore Protein-containing Complex Assembly
Pathways		MHC class II antigen presentation Regulation of PLK1 Activity at G2/M Transition HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand Loss of Nlp from mitotic centrosomes Recruitment of mitotic centrosome proteins and complexes Loss of proteins required for interphase microtubule organization from the centrosome Recruitment of NuMA to mitotic centrosomes Anchoring of the basal body to the plasma membrane COPI-mediated anterograde transport COPI-independent Golgi-to-ER retrograde traffic AURKA Activation by TPX2	Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal Separation of Sister Chromatids Resolution of Sister Chromatid Cohesion RHO GTPases Activate Formins COPI-dependent Golgi-to-ER retrograde traffic Mitotic Prometaphase EML4 and NUDC in mitotic spindle formation
Drugs
Diseases
GWAS		Brain morphology (MOSTest) ( 32665545)	Aging traits (healthspan, parental lifespan or longevity) (multivariate analysis) ( 32678081) Parental longevity (father's attained age) ( 29227965)
Interacting Genes		39 interacting genes: ABI2 BICD1 BICD2 BLOC1S1 BLOC1S2 BLOC1S6 CALM1 CCDC172 CENPH CEP44 COG3 DISC1 EGFR FXR1 FXR2 GADD45A GADD45G GNAO1 GOLM1 GRB2 GSK3B HAUS1 HGS KIFC3 KPNA2 MAPK6 MAPRE3 MARCKSL1 OGT PAFAH1B1 RABGEF1 RINT1 RPGR SHANK3 SMARCD1 TSC1 TXLNB USHBP1 ZW10	8 interacting genes: APP CEBPA DCTN2 PIAS4 PTF1A RINT1 ZWILCH ZWINT
Entrez ID		10540	9183
HPRD ID		09568	04902
Ensembl ID		ENSG00000175203	ENSG00000086827
Uniprot IDs		A0A384MDU9 A8K8J9 B3KTX4 Q13561 V9HW58	O43264
PDB IDs			7QPG
Enriched GO Terms of Interacting Partners?		Microtubule-based Process Organelle Organization Organelle Assembly Transport Along Microtubule Centrosome Cytoskeleton-dependent Intracellular Transport Cytoplasm Microtubule-based Transport Dynactin Binding Organelle Transport Along Microtubule Organelle Localization Cellular Localization Establishment Of Organelle Localization Regulation Of Dendritic Spine Development Membraneless Organelle Assembly Microtubule-based Movement Regulation Of Cytoskeleton Organization Microtubule Cytoskeleton Organization Intracellular Signal Transduction Positive Regulation Of Long-term Neuronal Synaptic Plasticity Protein Localization To Organelle Intracellular Transport Axo-dendritic Transport Cytosol Regulation Of Microtubule Cytoskeleton Organization Positive Regulation Of Dendritic Spine Development Cytoskeleton Regulation Of Dendritic Spine Morphogenesis Vesicle Transport Along Microtubule Intracellular Protein Localization Establishment Of Localization In Cell Retrograde Vesicle-mediated Transport, Golgi To Endoplasmic Reticulum BLOC-1 Complex Regulation Of Multicellular Organismal Process Anterograde Synaptic Vesicle Transport Regulation Of Organelle Organization Vesicle Cytoskeletal Trafficking Cytoskeleton Organization Positive Regulation Of Neurogenesis Axon Cytoplasm Modulation Of Chemical Synaptic Transmission Dynein Complex Binding Axonal Transport Central Region Of Growth Cone Regulation Of Translation At Presynapse, Modulating Synaptic Transmission Dsl1/NZR Complex Intracellular Signaling Cassette Cytoskeletal Anchor Activity Regulation Of Postsynapse Organization Regulation Of Microtubule-based Process	Intracellular Signal Transduction Regulation Of Mitotic Cell Cycle Regulation Of Cell Cycle Negative Regulation Of Cell Cycle Kinetochore Mitotic Spindle Assembly Checkpoint Signaling Negative Regulation Of Mitotic Metaphase/anaphase Transition Negative Regulation Of Mitotic Cell Cycle Phase Transition Negative Regulation Of Cell Cycle Phase Transition Negative Regulation Of Mitotic Cell Cycle Negative Regulation Of Mitotic Nuclear Division Negative Regulation Of Cell Cycle Process Amyloid-beta Complex Growth Cone Lamellipodium Regulation Of Response To Calcium Ion Amylin Binding Positive Regulation Of Toll Signaling Pathway Signal Transduction RNA Polymerase I Transcription Regulatory Region Sequence-specific DNA Binding Regulation Of Mitotic Cell Cycle Phase Transition Regulation Of Mitotic Sister Chromatid Separation Regulation Of Chromosome Separation Chromosome Localization Negative Regulation Of Chromosome Organization Acetylcholine Receptor Activator Activity Lipoprotein Particle Positive Regulation Of Protein Import Response To Vitamin B2 C/EBP Complex Knl1/Spc105 Complex Regulation Of Meiosis I Spindle Assembly Checkpoint Regulation Of Mitotic Metaphase/anaphase Transition Regulation Of Cell Cycle Phase Transition Homologous Chromosome Orientation In Meiotic Metaphase I Limb Epidermis Development PTB Domain Binding Collateral Sprouting In Absence Of Injury Regulation Of Protein Import Endosome To Plasma Membrane Transport Vesicle Positive Regulation Of Endothelin Production Growth Cone Filopodium Memory Notch Signaling Pathway Chromatin Binding Phospholipase D-activating G Protein-coupled Receptor Signaling Pathway Microglia Development Positive Regulation Of G Protein-coupled Receptor Internalization CHOP-C/EBP Complex Regulation Of Sister Chromatid Segregation Regulation Of Mitotic Nuclear Division
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