RPS6KA6 and MAPK3

Number of citations of the paper that reports this interaction (PMID 21900206)
27

Data Source:
BioGRID (two hybrid)

		RPS6KA6	MAPK3
Gene Name		ribosomal protein S6 kinase, 90kDa, polypeptide 6	mitogen-activated protein kinase 3
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm Nucleolus Mitochondrion Cytosol	Nucleus Nuclear Envelope Nucleoplasm Mitochondrion Early Endosome Late Endosome Golgi Apparatus Cytosol Cytoskeleton Caveola Focal Adhesion Microtubule Cytoskeleton Pseudopodium Extracellular Vesicular Exosome
	Molecular Function	Magnesium Ion Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity ATP Binding	Phosphotyrosine Binding MAP Kinase Activity Protein Binding ATP Binding Phosphatase Binding
	Biological Process	Protein Phosphorylation DNA Damage Response, Signal Transduction By P53 Class Mediator Resulting In Transcription Of P21 Class Mediator Signal Transduction Synaptic Transmission Axon Guidance Central Nervous System Development Negative Regulation Of Embryonic Development Negative Regulation Of ERK1 And ERK2 Cascade Negative Regulation Of Mesoderm Development	MAPK Cascade Activation Of MAPKK Activity Activation Of MAPK Activity Positive Regulation Of Protein Phosphorylation Toll-like Receptor Signaling Pathway MyD88-dependent Toll-like Receptor Signaling Pathway MyD88-independent Toll-like Receptor Signaling Pathway Transcription From RNA Polymerase I Promoter Transcription Initiation From RNA Polymerase I Promoter Protein Phosphorylation Apoptotic Process DNA Damage Induced Protein Phosphorylation Cell Cycle Epidermal Growth Factor Receptor Signaling Pathway Small GTPase Mediated Signal Transduction Ras Protein Signal Transduction Axon Guidance Blood Coagulation Insulin Receptor Signaling Pathway Fibroblast Growth Factor Receptor Signaling Pathway Organ Morphogenesis Gene Expression Viral Process Phosphorylation Cytokine-mediated Signaling Pathway Sensory Perception Of Pain Platelet Activation BMP Signaling Pathway Lipopolysaccharide-mediated Signaling Pathway Regulation Of Stress-activated MAPK Cascade Positive Regulation Of Histone Phosphorylation Toll-like Receptor 2 Signaling Pathway Toll-like Receptor 3 Signaling Pathway Toll-like Receptor 4 Signaling Pathway Toll-like Receptor 5 Signaling Pathway Toll-like Receptor 9 Signaling Pathway Toll-like Receptor 10 Signaling Pathway Cellular Response To Heat Positive Regulation Of Histone Acetylation TRIF-dependent Toll-like Receptor Signaling Pathway Peptidyl-tyrosine Autophosphorylation Fc-epsilon Receptor Signaling Pathway Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Toll-like Receptor TLR1:TLR2 Signaling Pathway Toll-like Receptor TLR6:TLR2 Signaling Pathway Response To Exogenous DsRNA Innate Immune Response Positive Regulation Of Transcription From RNA Polymerase II Promoter Vascular Endothelial Growth Factor Receptor Signaling Pathway Neurotrophin TRK Receptor Signaling Pathway Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Cartilage Development Stress-activated MAPK Cascade Regulation Of Cytoskeleton Organization JAK-STAT Cascade Involved In Growth Hormone Signaling Pathway Positive Regulation Of ERK1 And ERK2 Cascade Interleukin-1-mediated Signaling Pathway Response To Epidermal Growth Factor Cellular Response To Mechanical Stimulus Caveolin-mediated Endocytosis Regulation Of Golgi Inheritance Regulation Of Cellular Response To Heat Regulation Of Early Endosome To Late Endosome Transport Negative Regulation Of Apolipoprotein Binding
Pathways		Axon guidance RSK activation Activation of NMDA receptor upon glutamate binding and postsynaptic events L1CAM interactions Recycling pathway of L1 CREB phosphorylation through the activation of Ras Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell Transmission across Chemical Synapses Post NMDA receptor activation events	Signaling by FGFR in disease RNA Polymerase I, RNA Polymerase III, and Mitochondrial Transcription Cellular Senescence ERKs are inactivated Signaling by EGFRvIII in Cancer Toll Like Receptor TLR1:TLR2 Cascade Toll Like Receptor 5 (TLR5) Cascade Gastrin-CREB signalling pathway via PKC and MAPK MyD88 dependent cascade initiated on endosome SOS-mediated signalling Fcgamma receptor (FCGR) dependent phagocytosis SHC-mediated signalling Regulation of actin dynamics for phagocytic cup formation TRIF-mediated TLR3/TLR4 signaling ERK1 activation Senescence-Associated Secretory Phenotype (SASP) ERK1 activation Signaling by VEGF Downstream signal transduction Toll Like Receptor 3 (TLR3) Cascade Signalling to RAS Interleukin-2 signaling Platelet activation, signaling and aggregation Frs2-mediated activation Axon guidance IRS-mediated signalling L1CAM interactions Oncogene Induced Senescence VEGFA-VEGFR2 Pathway Activated TLR4 signalling VEGFR2 mediated cell proliferation GRB2 events in ERBB2 signaling TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation MyD88:Mal cascade initiated on plasma membrane NCAM signaling for neurite out-growth RAF/MAP kinase cascade Signalling to p38 via RIT and RIN Innate Immune System Signaling by Insulin receptor ERKs are inactivated Signal transduction by L1 Insulin receptor signalling cascade ISG15 antiviral mechanism Interferon Signaling Signaling by Ligand-Responsive EGFR Variants in Cancer IRS-related events SHC-related events Signaling by FGFR Thrombin signalling through proteinase activated receptors (PARs) ARMS-mediated activation Toll-Like Receptors Cascades Toll Like Receptor 10 (TLR10) Cascade Signal attenuation Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) ERK/MAPK targets MAPK targets/ Nuclear events mediated by MAP kinases Signaling by GPCR FCERI mediated MAPK activation SHC1 events in ERBB2 signaling Signaling by SCF-KIT DAP12 signaling Toll Like Receptor 9 (TLR9) Cascade ERK/MAPK targets Negative regulation of FGFR signaling Signaling by PDGF DAP12 interactions SHC-related events triggered by IGF1R GRB2 events in EGFR signaling Signaling by ERBB4 Antiviral mechanism by IFN-stimulated genes Toll Like Receptor 2 (TLR2) Cascade Signaling by ERBB2 Signaling by EGFR Signaling by Interleukins SHC1 events in ERBB4 signaling Toll Like Receptor 4 (TLR4) Cascade Fc epsilon receptor (FCERI) signaling Signaling by EGFR in Cancer Growth hormone receptor signaling Signaling by Leptin Signalling to ERKs Prolonged ERK activation events ERK activation Toll Like Receptor 7/8 (TLR7/8) Cascade RNA Polymerase I Promoter Clearance IGF1R signaling cascade Toll Like Receptor TLR6:TLR2 Cascade IRS-related events triggered by IGF1R Activation of the AP-1 family of transcription factors MyD88 cascade initiated on plasma membrane ERK activation Downstream signaling of activated FGFR Advanced glycosylation endproduct receptor signaling Signalling by NGF SOS-mediated signalling MAP kinase activation in TLR cascade RNA Polymerase I Transcription SHC-mediated signalling Cytokine Signaling in Immune system Cellular response to heat stress Regulation of HSF1-mediated heat shock response NGF signalling via TRKA from the plasma membrane MyD88-independent cascade Signaling by Overexpressed Wild-Type EGFR in Cancer SHC1 events in EGFR signaling FRS2-mediated cascade IRS-mediated signalling Oxidative Stress Induced Senescence RNA Polymerase I Promoter Opening Nuclear Events (kinase and transcription factor activation)
Drugs			Sulindac Arsenic trioxide Purvalanol 5-iodotubercidin
Diseases
GWAS			Pubertal anthropometrics ( 23449627)
Protein-Protein Interactions		28 interactors: ADIRF APP C14orf1 CEBPZ CENPB CLEC3B DHX34 DNAJC13 DNMT1 FBN3 FZD5 LMO4 MAPK3 MASP1 MED24 MICAL1 MPP1 NR4A1 RBPJ RPLP1 RXRA SAP30BP SPTBN4 SYNE4 UBE2I UFM1 ZNF227 ZNF746	161 interactors: ADRBK1 AKR1C1 AMOT ARRB1 ATP1A1 BAZ1B BCL2 BCL3 BTBD10 C1QBP CASP8 CASP9 CAV1 CCDC6 CDC23 CDC25C CEBPB CPXM1 CREBBP CREM CRP CUEDC2 DAPK1 DCC DCP1A DHPS DUSP1 DUSP10 DUSP3 DUSP4 DUSP5 DUSP6 DUSP9 ELK1 ELK4 EPOR ESR1 ETS1 ETV1 FCGR2B FKBP2 FOXP2 GAB1 GAB2 GATA1 GATA4 GJA1 GMFB GTF2I HDAC4 HDAC6 HIF1A HMMR HNF4A HSF1 HSF4 HSPB8 HTRA2 ID2 IER3 INSR JUN JUND KRT8 KSR2 L3MBTL3 LAMTOR3 LCK LIPE LRPAP1 LYN MAGEA11 MAGED1 MAP2K1 MAP2K2 MAP2K3 MAP3K1 MAP3K14 MAPK14 MAPK8 MAPKAPK2 MBP METAP2 MKNK1 MYC MYLK MYOG NAB2 NCKIPSD NGFR NTRK1 NTRK3 NUP153 NUPL1 PAK2 PDE6G PEA15 PFKFB1 PFKM PLAT PLCB1 PPARA PPP1CA PPP2CA PRKCD PRKCE PRKCZ PTPN11 PTPN5 PTPN7 PTPRE PTPRR PXN RAB4A RAF1 RALGDS RCAN1 RET RNF114 RPS6KA1 RPS6KA2 RPS6KA3 RPS6KA4 RPS6KA6 RPS6KB1 RPTOR RXRA SCAND1 SCRIB SMAD2 SNCG SORBS3 SP1 SPIB SREBF1 SREBF2 STAR STAT3 STAT5A STMN1 STMN2 SYK SYN1 SYNE2 TAL1 TAL2 TCF3 TGIF1 TH TNFSF11 TOP2B TP53 TRIM54 TSC2 TTYH3 UBTF VDR VPS52 ZC3HC1 ZNF219 ZNF7
Entrez ID		27330	5595
HPRD ID		02250	03479
Ensembl ID			ENSG00000102882
Uniprot IDs		Q9UK32	L7RXH5 P27361 Q9BWJ1
PDB IDs			2ZOQ
Enriched GO Terms of Interacting Partners?		Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Gene Expression Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription From RNA Polymerase II Promoter RNA Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of Nitrogen Compound Metabolic Process Regulation Of RNA Metabolic Process RNA Biosynthetic Process Positive Regulation Of Cellular Biosynthetic Process Gene Expression Regulation Of Metabolic Process Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Transcription, DNA-templated Positive Regulation Of Metabolic Process Nucleobase-containing Compound Metabolic Process DNA-templated Transcription, Initiation Positive Regulation Of Cellular Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Regulation Of Gene Expression Cellular Nitrogen Compound Metabolic Process Transcription From RNA Polymerase II Promoter Transcription Initiation From RNA Polymerase II Promoter Cellular Macromolecule Biosynthetic Process Nitrogen Compound Metabolic Process Macromolecule Biosynthetic Process Intracellular Receptor Signaling Pathway Regulation Of Protein Metabolic Process Regulation Of Protein Processing Regulation Of Early Endosome To Late Endosome Transport Cell Differentiation Biosynthetic Process Cardiac Ventricle Development Negative Regulation Of Cellular Metabolic Process Labyrinthine Layer Blood Vessel Development Sterol Metabolic Process Tissue Development Cardiac Chamber Development Neuron Maturation Regulation Of Cell Fate Commitment Apoptotic Process Cell Maturation Negative Regulation Of Protein Processing Regulation Of Cellular Process Tissue Morphogenesis Programmed Cell Death Placenta Blood Vessel Development	Response To Organic Substance Cellular Response To Organic Substance Enzyme Linked Receptor Protein Signaling Pathway Positive Regulation Of Cellular Metabolic Process Positive Regulation Of Metabolic Process Regulation Of Signaling Response To Growth Factor Cellular Response To Stimulus Cellular Response To Growth Factor Stimulus Regulation Of Signal Transduction Cell Communication Signaling Developmental Process Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Response To External Stimulus Response To Abiotic Stimulus Regulation Of Metabolic Process Signal Transduction Intracellular Signal Transduction Multicellular Organismal Development Response To Stimulus Regulation Of Protein Metabolic Process Regulation Of Cellular Process Anatomical Structure Development Response To Stress Regulation Of MAPK Cascade Positive Regulation Of Gene Expression Regulation Of Phosphorylation Regulation Of Cellular Protein Metabolic Process Cell Surface Receptor Signaling Pathway Organ Development Neurotrophin Signaling Pathway System Development Cell Differentiation Positive Regulation Of Signal Transduction Regulation Of Phosphorus Metabolic Process Neurotrophin TRK Receptor Signaling Pathway Signal Transduction By Phosphorylation Positive Regulation Of Cellular Biosynthetic Process Negative Regulation Of Cellular Metabolic Process Response To Lipid Regulation Of MAP Kinase Activity Positive Regulation Of Protein Metabolic Process Regulation Of Intracellular Signal Transduction Regulation Of Immune System Process Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of Catalytic Activity Anatomical Structure Morphogenesis Response To Hormone Regulation Of Cell Differentiation
Tagcloud ?		anchorage anticipated attribution azacytidine cdna chemoresponse clines codons deleted demethylation depended duplet encompass exclude exon immunoblots indolocarbazole isoforms nt nucleotides penultimate rsk4 situation sparse splice starvation suppressive triplet uncharacterized	5p acvr2a alters applying bmp bmp1a cleaves cluster copyright dies1 furin impairs interferes micrornas mineralization mir osteoblast osteoblasts protected reprogramming reserved rights ski smad smad5 smurf1 systematically tgfbr3 zfp423
Tagcloud (Difference) ?		anchorage anticipated attribution azacytidine cdna chemoresponse clines codons deleted demethylation depended duplet encompass exclude exon immunoblots indolocarbazole isoforms nt nucleotides penultimate rsk4 situation sparse splice starvation suppressive triplet uncharacterized	5p acvr2a alters applying bmp bmp1a cleaves cluster copyright dies1 furin impairs interferes micrornas mineralization mir osteoblast osteoblasts protected reprogramming reserved rights ski smad smad5 smurf1 systematically tgfbr3 zfp423
Tagcloud (Intersection) ?