LSM2 and GBP2

Number of citations of the paper that reports this interaction (PMID 16169070)
531

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		LSM2	GBP2
Gene Name		LSM2 homolog, U6 small nuclear RNA associated (S. cerevisiae)	guanylate binding protein 2, interferon-inducible
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleoplasm Cytosol Catalytic Step 2 Spliceosome	Golgi Membrane Nucleus Cytosol Symbiont-containing Vacuole Membrane Cytoplasmic Vesicle
	Molecular Function	Protein Binding U6 SnRNA Binding Ral GTPase Binding Protein Kinase Binding Poly(A) RNA Binding	GTPase Activity Protein Binding GTP Binding
	Biological Process	Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay MRNA Splicing, Via Spliceosome RNA Splicing Gene Expression Exonucleolytic Nuclear-transcribed MRNA Catabolic Process Involved In Deadenylation-dependent Decay	Immune Response Metabolic Process Cytokine-mediated Signaling Pathway Cellular Response To Interferon-beta Defense Response To Protozoan Adhesion Of Symbiont To Host Defense Response To Gram-positive Bacterium Interferon-gamma-mediated Signaling Pathway Type I Interferon Signaling Pathway Cellular Response To Lipopolysaccharide
Pathways		Processing of Capped Intron-Containing Pre-mRNA mRNA Splicing mRNA Splicing - Minor Pathway mRNA Splicing - Major Pathway mRNA decay by 5' to 3' exoribonuclease Deadenylation-dependent mRNA decay	Interferon gamma signaling Interferon Signaling Cytokine Signaling in Immune system Interferon alpha/beta signaling
Drugs
Diseases
GWAS
Protein-Protein Interactions		31 interactors: AES BANP C14orf1 CLNS1A CRMP1 DDX20 DNAJA1 EXOSC10 GBP2 KRT13 LNX1 LSM1 LSM3 LSM5 LSM6 LSM7 LSM8 MAGEA6 MEOX2 PRCC RALA REL RSRC1 SF3B2 SMN1 SNRPB SNRPD2 SNRPE TRIM54 ZBTB16 ZNF408	21 interactors: ANXA7 BID BNIP3L BTBD2 CSNK2B FXR1 GADD45A GSK3B HSPE1 KLHL20 LSM2 MAGI1 MAPK8IP2 PAFAH1B3 PPP1R8 RPS6KA1 SAT1 SEPHS1 SERPINB9 STK3 TFG
Entrez ID		57819	2634
HPRD ID		06282	02682
Ensembl ID		ENSG00000204392	ENSG00000162645
Uniprot IDs		Q9Y333	P32456 Q8TCE5
PDB IDs
Enriched GO Terms of Interacting Partners?		RNA Splicing MRNA Metabolic Process MRNA Processing RNA Splicing, Via Transesterification Reactions RNA Processing MRNA Splicing, Via Spliceosome RNA Metabolic Process Spliceosomal SnRNP Assembly Gene Expression Exonucleolytic Nuclear-transcribed MRNA Catabolic Process Involved In Deadenylation-dependent Decay Nuclear-transcribed MRNA Catabolic Process, Exonucleolytic Nucleobase-containing Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process Ribonucleoprotein Complex Biogenesis Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay Histone MRNA Metabolic Process Nitrogen Compound Metabolic Process Nuclear-transcribed MRNA Catabolic Process MRNA Catabolic Process Ribonucleoprotein Complex Assembly RNA Catabolic Process NcRNA Metabolic Process Aromatic Compound Catabolic Process Histone MRNA Catabolic Process Spliceosomal Complex Assembly Cellular Metabolic Process Cellular Macromolecule Catabolic Process Cellular Macromolecular Complex Assembly Metabolic Process Termination Of RNA Polymerase II Transcription Nuclear Retention Of Unspliced Pre-mRNA At The Site Of Transcription Catabolic Process DNA-templated Transcription, Termination Transcription From RNA Polymerase II Promoter MRNA 3'-end Processing Membrane Raft Localization Positive Regulation Of Anoikis Nuclear Polyadenylation-dependent RRNA Catabolic Process CUT Catabolic Process Embryonic Pattern Specification Cellular Process Positive Regulation Of Apoptotic Process Positive Regulation Of NK T Cell Differentiation Positive Regulation Of Programmed Cell Death Transcription, DNA-templated Positive Regulation Of Cell Death Male Germ-line Stem Cell Asymmetric Division Somite Specification	Cell Death Death Apoptotic Process Programmed Cell Death Regulation Of Cellular Protein Metabolic Process Regulation Of Protein Metabolic Process Regulation Of Apoptotic Process Regulation Of Cell Death Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Regulation Of Catalytic Activity Positive Regulation Of Cell Death Positive Regulation Of Cellular Protein Metabolic Process Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Regulation Of Cysteine-type Endopeptidase Activity Mitochondrial Outer Membrane Permeabilization Negative Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Protein Metabolic Process Positive Regulation Of Signal Transduction Positive Regulation Of Mitochondrial Membrane Permeability Involved In Apoptotic Process Negative Regulation Of Protein Metabolic Process Positive Regulation Of Mitochondrial Membrane Permeability Regulation Of MAPK Cascade Hepatocyte Apoptotic Process Regulation Of Mitochondrial Membrane Permeability Involved In Apoptotic Process Regulation Of Protein Phosphorylation Apoptotic Signaling Pathway Regulation Of Proteolysis Positive Regulation Of Stress-activated MAPK Cascade Positive Regulation Of Stress-activated Protein Kinase Signaling Cascade Response To Stimulus Positive Regulation Of Protein Phosphorylation Positive Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Regulation Of Endopeptidase Activity Regulation Of Protein Kinase Activity Regulation Of Peptidase Activity Regulation Of JNK Cascade Regulation Of Intracellular Signal Transduction Negative Regulation Of Catalytic Activity Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Regulation Of Kinase Activity Regulation Of Mitochondrial Membrane Permeability Catabolic Process Positive Regulation Of Intracellular Signal Transduction Regulation Of Membrane Permeability Regulation Of Stress-activated MAPK Cascade Regulation Of Phosphorylation Social Behavior Positive Regulation Of Phosphorylation Response To Organic Substance
Tagcloud ?		angles arrange assemble building heptameric heteroheptameric hexameric incorporate lsm1 lsm23 lsm5 lsm57 lsm6 lsm657 lsm7 monomers nonetheless plastic pockets preferences pull ring sme smf smg solved spliceosomal	anthracycline besides carcinomas chemotherapy erbb2 fast grading guanylate hazard inducible infiltration interestingly interferon kappa metalloproteinase node odds pathologically probably prognosis proliferating pt rac reach receive represents signature subgroups univariate
Tagcloud (Difference) ?		angles arrange assemble building heptameric heteroheptameric hexameric incorporate lsm1 lsm23 lsm5 lsm57 lsm6 lsm657 lsm7 monomers nonetheless plastic pockets preferences pull ring sme smf smg solved spliceosomal	anthracycline besides carcinomas chemotherapy erbb2 fast grading guanylate hazard inducible infiltration interestingly interferon kappa metalloproteinase node odds pathologically probably prognosis proliferating pt rac reach receive represents signature subgroups univariate
Tagcloud (Intersection) ?