RNF115 and UBE2W

Number of citations of the paper that reports this interaction (PMID 19690564)
33

Data Source:
BioGRID (two hybrid)

		RNF115	UBE2W
Gene Name		ring finger protein 115	ubiquitin-conjugating enzyme E2W (putative)
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Cytosol	Nucleus Cytoplasm
	Molecular Function	Ubiquitin-protein Transferase Activity Protein Binding Zinc Ion Binding Ligase Activity Ubiquitin Protein Ligase Activity	Ubiquitin-protein Transferase Activity ATP Binding Ligase Activity Ubiquitin-like Protein Transferase Activity Ubiquitin Protein Ligase Binding Ubiquitin Protein Ligase Activity
	Biological Process	Negative Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Ubiquitin-dependent Protein Catabolic Process Via The Multivesicular Body Sorting Pathway Protein Autoubiquitination Protein K63-linked Ubiquitination Protein K48-linked Ubiquitination	DNA Repair Protein Monoubiquitination Misfolded Or Incompletely Synthesized Protein Catabolic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Protein K11-linked Ubiquitination Cellular Response To Misfolded Protein
Pathways			Antigen processing: Ubiquitination & Proteasome degradation Class I MHC mediated antigen processing & presentation Adaptive Immune System
Drugs
Diseases
GWAS
Protein-Protein Interactions		27 interactors: AKT1 APP ATN1 CDK10 CST3 DAZAP2 DOCK4 EGFR FOLR3 HRAS IGHA1 MDM4 MFAP4 RAB7A RAD23A RPL18A SSSCA1 TTR UBE2D1 UBE2D2 UBE2D3 UBE2D4 UBE2E1 UBE2E3 UBE2I UBE2N UBE2W	69 interactors: AKR1C3 AMFR BARD1 BFAR BIRC2 BIRC8 BRCA1 CADPS2 CHFR CNOT4 DNMT3B DTX3 DTX3L DZIP3 EED FANCL LRSAM1 MAP3K1 MARCH3 MARCH5 MGRN1 MIB1 MID1 MKRN1 MKRN3 MUL1 PJA2 POLR2C PSTPIP1 RFWD3 RMND5B RNF10 RNF103 RNF111 RNF114 RNF115 RNF123 RNF125 RNF138 RNF14 RNF150 RNF152 RNF165 RNF166 RNF167 RNF185 RNF2 RNF26 RNF4 RNF5 RNF8 ROPN1 STUB1 TOPORS TRIM17 TRIM2 TRIM27 TRIM31 TRIM35 TRIM39 TRIM8 UBA1 UBOX5 UFM1 UHRF2 USHBP1 XIAP ZNRF1 ZNRF4
Entrez ID		27246	55284
HPRD ID		18328	07724
Ensembl ID			ENSG00000104343
Uniprot IDs		Q9Y4L5	Q96B02 Q96FI0
PDB IDs			2A7L
Enriched GO Terms of Interacting Partners?		Protein K48-linked Ubiquitination Protein Polyubiquitination Protein Ubiquitination Protein Modification By Small Protein Conjugation Protein Catabolic Process Cellular Protein Catabolic Process Protein K11-linked Ubiquitination Cellular Macromolecule Catabolic Process Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Cellular Response To Hypoxia Cellular Response To Decreased Oxygen Levels Proteolysis Involved In Cellular Protein Catabolic Process Response To Abiotic Stimulus Cellular Response To Oxygen Levels Regulation Of Protein Catabolic Process Cellular Protein Metabolic Process Negative Regulation Of Protein Catabolic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Proteasomal Protein Catabolic Process Immune Response-regulating Signaling Pathway Defense Response Catabolic Process Cellular Protein Modification Process Response To Light Stimulus Innate Immune Response Positive Regulation Of Transferase Activity Toll-like Receptor 4 Signaling Pathway Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia Regulation Of Cell Cycle Regulation Of Mitotic Cell Cycle Immune Response Protein Metabolic Process Mitotic Cell Cycle Process Toll-like Receptor Signaling Pathway Protein K63-linked Ubiquitination Response To Radiation Cell Cycle Process Regulation Of Cell Cycle Process Mitotic Cell Cycle Regulation Of Transcription From RNA Polymerase II Promoter Pattern Recognition Receptor Signaling Pathway Innate Immune Response-activating Signal Transduction Protein Monoubiquitination Regulation Of Metabolic Process Response To Hypoxia Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Response To UV-A Activation Of Innate Immune Response Response To Stress	Protein Modification By Small Protein Conjugation Protein Ubiquitination Cellular Protein Modification Process Protein Polyubiquitination Cellular Protein Metabolic Process Protein Metabolic Process Protein Autoubiquitination Cellular Metabolic Process Protein K48-linked Ubiquitination Protein Catabolic Process Modification-dependent Protein Catabolic Process Proteolysis Involved In Cellular Protein Catabolic Process Cellular Protein Catabolic Process Protein K63-linked Ubiquitination Cellular Macromolecule Catabolic Process Ubiquitin-dependent Protein Catabolic Process Metabolic Process Cellular Response To Stress Catabolic Process Protein Monoubiquitination Response To Stress Cellular Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Regulation Of Viral Release From Host Cell Proteasomal Protein Catabolic Process Protein K6-linked Ubiquitination Regulation Of Protein Ubiquitination Cellular Response To DNA Damage Stimulus Inhibition Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Positive Regulation Of Protein Ubiquitination Negative Regulation Of Viral Release From Host Cell DNA Repair Negative Regulation Of Viral Transcription Proteolysis Apoptotic Process Regulation Of Gene Expression By Genetic Imprinting Regulation Of Viral Transcription Programmed Cell Death Negative Regulation Of Viral Process Regulation Of Viral Process Cell Death Death Positive Regulation Of Organelle Organization Genetic Imprinting Positive Regulation Of Protein Modification Process Regulation Of Organelle Organization Ubiquitin-dependent SMAD Protein Catabolic Process Positive Regulation Of Histone Methylation Histone Ubiquitination Cellular Response To Stimulus
Tagcloud ?			advance amines chemically cleave cleaving deubiquitylating displaying dub dubs fusions homopolymers hydrolase isopeptide k11 l3 linkage linkages mono monoubiquitylation preference reversal striking sumo2 synthesised topologically ubiquitylation uch unstructured
Tagcloud (Difference) ?			advance amines chemically cleave cleaving deubiquitylating displaying dub dubs fusions homopolymers hydrolase isopeptide k11 l3 linkage linkages mono monoubiquitylation preference reversal striking sumo2 synthesised topologically ubiquitylation uch unstructured
Tagcloud (Intersection) ?