CREB3 and BNIP3

Number of citations of the paper that reports this interaction (PubMedID 21516116)
20

Data Source:
BioGRID (two hybrid)

		CREB3	BNIP3
Description		cAMP responsive element binding protein 3	BCL2 interacting protein 3
Image		No pdb structure
GO Annotations	Cellular Component	Golgi Membrane Chromatin Nucleus Nucleoplasm Cytoplasm Endoplasmic Reticulum Endoplasmic Reticulum Membrane Golgi Apparatus Cytosol Membrane Nuclear Body Neuronal Cell Body RNA Polymerase II Transcription Regulator Complex	Nucleus Nuclear Envelope Nucleoplasm Cytoplasm Mitochondrion Mitochondrial Envelope Mitochondrial Outer Membrane Endoplasmic Reticulum Endoplasmic Reticulum Membrane Postsynaptic Density Membrane Dendrite Mitochondrial Membrane
	Molecular Function	RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Transcription Coregulator Binding DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding Chromatin Binding DNA-binding Transcription Factor Activity Protein Binding CAMP Response Element Binding Protein Binding CCR1 Chemokine Receptor Binding Identical Protein Binding Protein Homodimerization Activity Protein Dimerization Activity Sequence-specific Double-stranded DNA Binding	Protein Binding Identical Protein Binding Protein Homodimerization Activity GTPase Binding Endoplasmic Reticulum-autophagosome Adaptor Activity Mitochondrion Autophagosome Adaptor Activity
	Biological Process	Regulation Of Cell Growth DNA-templated Transcription Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Chemotaxis Response To Unfolded Protein Release From Viral Latency Positive Regulation Of Cell Migration Endoplasmic Reticulum Unfolded Protein Response Response To Endoplasmic Reticulum Stress Regulation Of Cell Population Proliferation Regulation Of Apoptotic Process Negative Regulation Of Cell Cycle Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Induction Of Positive Chemotaxis Positive Regulation Of Calcium Ion Transport Positive Regulation Of Monocyte Chemotaxis Positive Regulation Of Deacetylase Activity Integrated Stress Response Signaling Negative Regulation Of Endoplasmic Reticulum Stress-induced Intrinsic Apoptotic Signaling Pathway	Autophagy Of Mitochondrion Mitophagy Response To Hypoxia Apoptotic Process Response To Bacterium Positive Regulation Of Autophagy Negative Regulation Of Mitochondrial Fusion Cardiac Muscle Cell Apoptotic Process Positive Regulation Of Cardiac Muscle Cell Apoptotic Process Negative Regulation Of Mitochondrial Membrane Potential Positive Regulation Of Macroautophagy Cerebral Cortex Development Mitochondrial Protein Catabolic Process Positive Regulation Of Apoptotic Process Negative Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Negative Regulation Of Programmed Cell Death Positive Regulation Of Protein-containing Complex Disassembly Mitochondrial Fragmentation Involved In Apoptotic Process Negative Regulation Of Membrane Potential Regulation Of Mitochondrial Membrane Permeability Autophagic Cell Death Response To Axon Injury Oligodendrocyte Differentiation Brown Fat Cell Differentiation Neuron Apoptotic Process Positive Regulation Of Mitochondrial Calcium Ion Concentration Defense Response To Virus Response To Hyperoxia Reticulophagy Substrate Localization To Autophagosome Cellular Response To Hydrogen Peroxide Cellular Response To Mechanical Stimulus Cellular Response To Cobalt Ion Cellular Response To Hypoxia Reactive Oxygen Species Metabolic Process Positive Regulation Of Mitochondrial Fission Positive Regulation Of Release Of Cytochrome C From Mitochondria Response To Oxygen-glucose Deprivation Intrinsic Apoptotic Signaling Pathway Mitochondrial Outer Membrane Permeabilization Granzyme-mediated Programmed Cell Death Signaling Pathway Negative Regulation Of Mitochondrial Membrane Permeability Involved In Apoptotic Process Positive Regulation Of Autophagy Of Mitochondrion Intrinsic Apoptotic Signaling Pathway In Response To Hypoxia
Pathways		CREB3 factors activate genes CREB3 factors activate genes
Drugs
Diseases
GWAS		Brain morphology (MOSTest) ( 32665545)	Cognitive ability, years of educational attainment or schizophrenia (pleiotropy) ( 31374203) Metabolite levels ( 23823483)
Interacting Genes		205 interacting genes: ABHD16A ACKR2 ACSF2 ACSL5 ADTRP AGER AGPAT3 ALG3 ALG8 APH1A APOA2 APOD APPBP2 AQP1 AQP2 AQP4 AQP5 ATF3 ATF4 ATP6AP2 ATP6V0C BCAP29 BCAT2 BCL2L1 BIK BNIP2 BNIP3 BTN2A2 C2 C3orf52 CACFD1 CCR1 CD207 CD82 CDS2 CEBPG CELA3A CES1 CFHR5 CGRRF1 CHMP7 CLCN7 CLDN19 CLDND2 CLP1 CMTM5 CNPY3 CREB3L1 CREB3L3 CT45A5 CTSW CYB561 CYB5B CYBC1 CYBRD1 CYP4F2 DDIT3 DNAJC30 DOLK DRAM1 EBP EMC6 EMD ERG28 FA2H FAM3A FAM3C FDFT1 FDPS FIS1 FMO1 FMO3 FXYD3 FXYD6 GJA1 GJB2 GYPA HCFC1 HDAC3 HMOX1 HVCN1 ICAM4 IGFBP5 ITM2B JUN KCNK1 KLHL30-AS1 KRTCAP2 LAT LHFPL5 LILRB5 LMBR1L LMNA LPCAT2 LTA MAL2 MALL MARCHF5 MFSD11 MGST2 MRPL57 MS4A1 MYADM NAA10 NDUFB6 NEU1 NFE2L2 NFE2L3 NFIL3 NKG7 NRG4 ORMDL1 OS9 P4HA2 PLLP PLN PLP1 PLPP1 PLTP PMP22 PNLIPRP1 PSENEN PTCH1 PTDSS1 PTPN9 RAB23 RABAC1 RHEB RIMS3 RPRM RPS3A RRAS2 RUSF1 SACM1L SAR1B SCAMP4 SCAMP5 SCLY SCP2 SEC22B SEC61G SELENOK SERINC1 SFT2D2 SFTPC SFXN3 SHMT2 SLC19A3 SLC29A1 SLC29A2 SLC29A3 SLC2A3 SLC2A4 SLC30A2 SLC35H1 SLC38A1 SLC39A13 SLC41A2 SLC41A3 SLC49A3 SLC50A1 SLC61A1 SLC7A9 SPOCK3 SQLE ST6GAL2 STARD3 STX7 STX8 SYNGR1 SYNPR TAP1 TECR TIMM17B TIMM23B TM4SF4 TMEM100 TMEM115 TMEM140 TMEM14A TMEM14B TMEM14C TMEM19 TMEM203 TMEM222 TMEM230 TMEM234 TMEM243 TMEM51 TMEM54 TRAM1 TRAM1L1 TSPAN2 TSPAN4 TSPAN7 TTLL5 UBE2J1 UNC50 USE1 VKORC1 VTI1B YIPF2 ZDHHC11 ZDHHC21 ZDHHC9	71 interacting genes: AGTR1 AMIGO1 ARL13B BCL2 BCL2L1 BCL2L2 BIK BNIP2 BNIP3L CD3E CD47 CLDN9 CLEC7A CLN8 CMTM5 CREB3 CREB3L1 EBAG9 EBP ELOVL4 ERGIC3 FAM209A FAM241B FATE1 FBXL4 FFAR2 FXYD6-FXYD2 GPR152 GPR37 GPR42 HIF1A HIVEP1 HPN HTR2B IFNGR2 JAGN1 KTN1 LDLRAD1 LMNA MALL MAP1LC3B MS4A3 NCBP1 OPA1 PLP2 PPTC7 REEP2 RHEB RNASEK RNF24 RPRM SCN3B SEC22A SEC23A SLC31A2 SLC35B1 SLC6A17 SLC71A2 SMIM3 SPACA1 TGM2 TLCD4 TM4SF18 TMEM101 TMEM106C TMEM11 TMEM205 TMPRSS2 TMX2 TNMD ZDHHC15
Entrez ID		10488	664
HPRD ID		07339	04482
Ensembl ID		ENSG00000107175	ENSG00000176171
Uniprot IDs		O43889	Q12983 Q6NVY4
PDB IDs			2J5D 2KA1 2KA2
Enriched GO Terms of Interacting Partners?		Membrane Endoplasmic Reticulum Endoplasmic Reticulum Membrane Protein Binding Transmembrane Transport Chemical Homeostasis Small Molecule Biosynthetic Process Endomembrane System Lipid Biosynthetic Process Homeostatic Process Uracil Transmembrane Transport Pyrimidine Nucleobase Transmembrane Transport Uracil Transmembrane Transporter Activity Lipid Metabolic Process Golgi Apparatus Golgi Membrane Structural Constituent Of Myelin Sheath Response To Endoplasmic Reticulum Stress Integrated Stress Response Signaling Cytidine Transport Guanine Transport Adenosine Transport Cytidine Transmembrane Transporter Activity Guanine Transmembrane Transporter Activity Inosine Transport Guanine Transmembrane Transport Intracellular Chemical Homeostasis Plasma Membrane Steroid Biosynthetic Process Apical Plasma Membrane Cellular Homeostasis Sterol Biosynthetic Process Lysosomal Membrane Pyrimidine-containing Compound Transmembrane Transport Small Molecule Metabolic Process Pyrimidine Nucleoside Transport Nucleoside Transmembrane Transporter Activity Uridine Transmembrane Transporter Activity Uridine Transmembrane Transport Water Channel Activity Nucleoside Transport Nucleoside Transmembrane Transport Pyrimidine Nucleobase Transport Membrane Organization Regulation Of Lipid Transport Transmembrane Transporter Activity Purine Nucleobase Transmembrane Transport Chloride Channel Inhibitor Activity Protein Palmitoylation Organophosphate Biosynthetic Process	Membrane Endoplasmic Reticulum Endoplasmic Reticulum Membrane Bcl-2 Family Protein Complex Protein Binding Negative Regulation Of Endoplasmic Reticulum Stress-induced Intrinsic Apoptotic Signaling Pathway Mitochondrial Outer Membrane Negative Regulation Of Intrinsic Apoptotic Signaling Pathway Mitochondrial Membrane Organization Apoptotic Mitochondrial Changes Negative Regulation Of Apoptotic Process Mitochondrial Membrane Mitochondrion Organization Regulation Of Endoplasmic Reticulum Stress-induced Intrinsic Apoptotic Signaling Pathway Negative Regulation Of Programmed Cell Death Regulation Of Release Of Cytochrome C From Mitochondria Dendritic Cell Apoptotic Process Negative Regulation Of Apoptotic Signaling Pathway Negative Regulation Of Release Of Cytochrome C From Mitochondria Negative Regulation Of Response To Endoplasmic Reticulum Stress Regulation Of Apoptotic Process Golgi Membrane Negative Regulation Of Autophagy Regulation Of Programmed Cell Death Release Of Cytochrome C From Mitochondria Regulation Of Intrinsic Apoptotic Signaling Pathway BH3 Domain Binding Apoptotic Process Membrane Organization Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Programmed Cell Death Cell Death Positive Regulation Of Cell Maturation Negative Regulation Of Dendritic Cell Apoptotic Process Channel Activity Regulation Of Response To Endoplasmic Reticulum Stress Ceramide Binding Transmembrane Transport Chemical Homeostasis Mitochondrion
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