CREB3 and ATF3

Number of citations of the paper that reports this interaction (PMID 23661758)
2

Data Source:
BioGRID (fluorescent resonance energy transfer)

		CREB3	ATF3
Gene Name		cAMP responsive element binding protein 3	activating transcription factor 3
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Golgi Membrane Nucleus Cytoplasm Endoplasmic Reticulum Endoplasmic Reticulum Membrane Golgi Apparatus Cytosol Membrane Integral Component Of Membrane Nuclear Body Integral Component Of Endoplasmic Reticulum Membrane Neuronal Cell Body	Nucleus Nucleoplasm Nucleolus
	Molecular Function	RNA Polymerase II Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding Transcription Factor Activity RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding Transcription Factor Activity Involved In Positive Regulation Of Transcription DNA Binding Chromatin Binding Sequence-specific DNA Binding Transcription Factor Activity Protein Binding CAMP Response Element Binding Protein Binding CCR1 Chemokine Receptor Binding CAMP Response Element Binding Protein Homodimerization Activity Protein Dimerization Activity	RNA Polymerase II Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding Transcription Factor Activity Involved In Negative Regulation Of Transcription RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding Transcription Factor Activity Involved In Positive Regulation Of Transcription Sequence-specific DNA Binding Transcription Factor Activity Transcription Corepressor Activity Protein Binding Identical Protein Binding
	Biological Process	Regulation Of Cell Growth Positive Regulation Of Defense Response To Virus By Host Transcription, DNA-templated Transcription From RNA Polymerase II Promoter Chemotaxis Positive Regulation Of Transcription From RNA Polymerase II Promoter Involved In Unfolded Protein Response Viral Process Establishment Of Viral Latency Release From Viral Latency Positive Regulation Of Cell Migration Response To Endoplasmic Reticulum Stress Regulation Of Cell Proliferation Cytoplasmic Sequestering Of Transcription Factor Negative Regulation Of Cell Cycle Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription From RNA Polymerase II Promoter Induction Of Positive Chemotaxis Positive Regulation Of Calcium Ion Transport Positive Regulation Of Monocyte Chemotaxis Positive Regulation Of Deacetylase Activity Negative Regulation Of Endoplasmic Reticulum Stress-induced Intrinsic Apoptotic Signaling Pathway Negative Regulation Of Ligand-dependent Nuclear Receptor Transcription Coactivator Activity	Negative Regulation Of Transcription From RNA Polymerase II Promoter Gluconeogenesis Transcription, DNA-templated Activation Of Signaling Protein Activity Involved In Unfolded Protein Response Positive Regulation Of Cell Proliferation Endoplasmic Reticulum Unfolded Protein Response Skeletal Muscle Cell Differentiation Cellular Protein Metabolic Process Positive Regulation Of Transcription From RNA Polymerase II Promoter
Pathways			ATF4 activates genes PERK regulates gene expression Unfolded Protein Response (UPR)
Drugs
Diseases
GWAS
Protein-Protein Interactions		25 interactors: APPBP2 ATF3 ATF4 BCAT2 BNIP2 CCR1 CEBPG CLP1 CREB3L1 CREB3L3 DDIT3 EMD HCFC1 HDAC3 JUN MALL NFE2L2 NFE2L3 NFIL3 OS9 RABAC1 RRAS2 SQLE STX8 TTLL5	41 interactors: ATF2 ATF4 BATF BATF3 CEBPA CEBPE CEBPG CREB3 CREBBP DBP DDIT3 FGFR3 FOS FOSL1 HDAC1 HDAC3 HDAC4 HDAC5 HDAC6 ID3 IGSF21 JUN JUNB JUND LRIF1 MAFF MAFG MDM2 NFKB1 NUF2 PDX1 POLR3D SMAD3 SRA1 SS18L1 STAT1 SUMO1 SUMO3 SUV39H1 TP53 ZNF212
Entrez ID		10488	467
HPRD ID		07339	04395
Ensembl ID		ENSG00000107175	ENSG00000162772
Uniprot IDs		O43889	P18847
PDB IDs
Enriched GO Terms of Interacting Partners?		Response To Endoplasmic Reticulum Stress Transcription From RNA Polymerase II Promoter Endoplasmic Reticulum Unfolded Protein Response Cellular Response To Unfolded Protein ER-nucleus Signaling Pathway Cellular Response To Topologically Incorrect Protein Response To Unfolded Protein Regulation Of Transcription From RNA Polymerase II Promoter Transcription, DNA-templated RNA Biosynthetic Process Positive Regulation Of Transcription From RNA Polymerase II Promoter Cellular Response To Organic Substance Positive Regulation Of Gene Expression Response To Organic Substance Regulation Of Transcription From RNA Polymerase II Promoter In Response To Stress Positive Regulation Of Transcription From RNA Polymerase II Promoter In Response To Stress Positive Regulation Of Transcription, DNA-templated Regulation Of DNA-templated Transcription In Response To Stress RNA Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Gene Expression Biosynthetic Process Cellular Macromolecule Biosynthetic Process Positive Regulation Of Cellular Biosynthetic Process Macromolecule Biosynthetic Process Positive Regulation Of Cellular Metabolic Process Negative Regulation Of Gene Expression Positive Regulation Of Metabolic Process Positive Regulation Of Transcription From RNA Polymerase II Promoter In Response To Oxidative Stress Cellular Aromatic Compound Metabolic Process Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Transcription From RNA Polymerase II Promoter Negative Regulation Of Nucleic Acid-templated Transcription Cellular Response To Stress Negative Regulation Of RNA Biosynthetic Process Positive Regulation Of Transcription From RNA Polymerase II Promoter In Response To Endoplasmic Reticulum Stress Cellular Nitrogen Compound Metabolic Process Activation Of Signaling Protein Activity Involved In Unfolded Protein Response Nucleobase-containing Compound Metabolic Process Positive Regulation Of Nuclease Activity Regulation Of Phosphorylation Circadian Rhythm Negative Regulation Of Biosynthetic Process Positive Regulation Of Neuron Apoptotic Process Response To Stress Nitrogen Compound Metabolic Process Heterocycle Metabolic Process Regulation Of Gene Expression Positive Regulation Of Neuron Death Regulation Of Phosphorus Metabolic Process	Transcription, DNA-templated RNA Biosynthetic Process Regulation Of Transcription From RNA Polymerase II Promoter RNA Metabolic Process Regulation Of Transcription, DNA-templated Gene Expression Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Transcription From RNA Polymerase II Promoter Regulation Of Gene Expression Regulation Of Nitrogen Compound Metabolic Process Nucleobase-containing Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process Positive Regulation Of Transcription From RNA Polymerase II Promoter Biosynthetic Process Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Gene Expression Nitrogen Compound Metabolic Process Positive Regulation Of Cellular Metabolic Process Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Response To Stress Positive Regulation Of Cellular Biosynthetic Process Regulation Of Metabolic Process Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Biosynthetic Process Negative Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Metabolic Process Negative Regulation Of Gene Expression Cellular Metabolic Process Response To Organic Substance Regulation Of Cell Differentiation Response To External Stimulus Negative Regulation Of Cellular Metabolic Process Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Defense Response Cellular Response To Organic Substance Cell Differentiation Immune System Process Histone H3-K9 Modification Developmental Process Rhythmic Process Regulation Of Cell Death Response To Biotic Stimulus
Tagcloud ?		atf6 beyond bzip elucidate endoplasmic expands inducers intramembrane knockouts l4 mammals members microarray proteolysis proteolytic proteolytically recognition reticulum rnai screens similarity spectrum stimulate subfamily thought tumorigenesis unfolded upr	activating attenuation beneficial caat chop combating contributes diabetogenic dietary elevation elicited endoplasmic enhancer evoked fatty hdac1 hdac3 homologous islets lipotoxicity mimicked min6 ms palmitate preserving prevents reticulum saturated silencing
Tagcloud (Difference) ?		atf6 beyond bzip elucidate expands inducers intramembrane knockouts l4 mammals members microarray proteolysis proteolytic proteolytically recognition rnai screens similarity spectrum stimulate subfamily thought tumorigenesis unfolded upr	activating attenuation beneficial caat chop combating contributes diabetogenic dietary elevation elicited enhancer evoked fatty hdac1 hdac3 homologous islets lipotoxicity mimicked min6 ms palmitate preserving prevents saturated silencing
Tagcloud (Intersection) ?		endoplasmic reticulum