EXO1 and YWHAB

Number of citations of the paper that reports this interaction (PubMedID 35271311)
106

Data Source:
BioGRID (affinity chromatography technology, proximity labelling technology, two hybrid, affinity chromatography technology, two hybrid, pull down, affinity chromatography technology)

		EXO1	YWHAB
Description		exonuclease 1	tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein beta
Image
GO Annotations	Cellular Component	Nucleus Nucleoplasm Plasma Membrane Nuclear Body	Nucleus Cytoplasm Vacuole Vacuolar Membrane Cytosol Focal Adhesion Membrane Transcription Repressor Complex Protein-containing Complex Melanosome Perinuclear Region Of Cytoplasm Extracellular Exosome
	Molecular Function	DNA Binding Chromatin Binding Catalytic Activity Nuclease Activity Endonuclease Activity DNA Endonuclease Activity RNA-DNA Hybrid Ribonuclease Activity Exonuclease Activity Protein Binding 5'-3' Exonuclease Activity Hydrolase Activity Hydrolase Activity, Acting On Ester Bonds 5'-flap Endonuclease Activity 5'-3' DNA Exonuclease Activity Single-stranded DNA 5'-3' DNA Exonuclease Activity Metal Ion Binding Flap Endonuclease Activity Double-stranded DNA 5'-3' DNA Exonuclease Activity	Protein Kinase Inhibitor Activity Protein Phosphatase Inhibitor Activity Protein Binding Enzyme Binding Protein Domain Specific Binding Identical Protein Binding Histone Deacetylase Binding Protein-containing Complex Binding Cadherin Binding Phosphoserine Residue Binding Phosphoprotein Binding Protein Sequestering Activity
	Biological Process	Immune System Process Humoral Immune Response Mediated By Circulating Immunoglobulin DNA Repair Mismatch Repair DNA Recombination DNA Damage Response Somatic Hypermutation Of Immunoglobulin Genes Isotype Switching Meiotic Cell Cycle T-circle Formation DNA Strand Resection Involved In Replication Fork Processing	Protein Targeting Signal Transduction Intracellular Protein Localization Negative Regulation Of Protein Import Into Nucleus Negative Regulation Of G Protein-coupled Receptor Signaling Pathway Negative Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II
Pathways		Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha) Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta) HDR through Single Strand Annealing (SSA) HDR through Homologous Recombination (HRR) Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA) Resolution of D-loop Structures through Holliday Junction Intermediates Homologous DNA Pairing and Strand Exchange Processing of DNA double-strand break ends Presynaptic phase of homologous DNA pairing and strand exchange Regulation of TP53 Activity through Phosphorylation G2/M DNA damage checkpoint Defective homologous recombination repair (HRR) due to BRCA1 loss of function Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function Impaired BRCA2 binding to RAD51 Impaired BRCA2 binding to PALB2	Activation of BAD and translocation to mitochondria Translocation of SLC2A4 (GLUT4) to the plasma membrane MTOR signalling mTORC1-mediated signalling Frs2-mediated activation Frs2-mediated activation ARMS-mediated activation Signaling by Hippo Rap1 signalling Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA RHO GTPases activate PKNs TP53 Regulates Metabolic Genes RAF activation MAP2K and MAPK activation Negative regulation of MAPK pathway Signaling by moderate kinase activity BRAF mutants Signaling by high-kinase activity BRAF mutants Signaling by BRAF and RAF1 fusions Paradoxical activation of RAF signaling by kinase inactive BRAF Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex Regulation of localization of FOXO transcription factors Signaling downstream of RAS mutants Signaling by RAF1 mutants SHOC2 M1731 mutant abolishes MRAS complex function Gain-of-function MRAS complexes activate RAF signaling SARS-CoV-1 targets host intracellular signalling and regulatory pathways SARS-CoV-2 targets host intracellular signalling and regulatory pathways Transcriptional and post-translational regulation of MITF-M expression and activity
Drugs			Copper Phenethyl Isothiocyanate
Diseases
GWAS		Basal cell carcinoma ( 31174203) Breast cancer ( 25751625 29059683) Eosinophil count ( 32888494) Eosinophil percentage of white cells ( 32888494) Gut microbiota (bacterial taxa, hurdle binary method) ( 32572223) Keratinocyte cancer (MTAG) ( 31174203) Mean corpuscular hemoglobin ( 32888494) Mean corpuscular volume ( 32888494) Menopause (age at onset) ( 22267201 26414677)	Basophil count ( 32888494) Basophil percentage of white cells ( 32888494) Blood protein levels ( 30072576) Breakfast cereal skipping frequency ( 31190057) Breakfast skipping ( 31190057) Mean platelet volume ( 32888494)
Interacting Genes		20 interacting genes: ATM BLM DCAF1 H4C1 KPNA4 KPNB1 MLH1 MLH3 MSH2 MSH3 PCNA PMS2 SENP6 SFN UBE2I YWHAB YWHAE YWHAG YWHAH YWHAZ	147 interacting genes: ABL1 ADAM22 AFDN AKAP13 ALS2 APP ATP5F1A BAD BAX BCL2L11 BCR BID BRAF C1QBP CAMK2A CAMK2B CBL CDC25A CDC25B CDC25C CDK11B CDK14 CDKN1B CHAF1A CRTC2 CSNK2A1 DAPK1 DHX15 DYRK1A EDC3 EGFR EPB41 EPB41L1 EPB41L3 ERRFI1 EXO1 FER FILNC1 FRMD6 GAPVD1 GEM H3C1 HDAC5 HES1 HSP90AB1 HSPA1A HSPA1B HSPA5 HSPB1 IGF1R IKBKB ING1 INSR IRS1 IRS2 ITGB1 ITGB4 KANK1 KCNK15 KCNK3 KCNK9 KIAA0930 KIF1C KIF23 KIF5B KLC1 KRT18 LARP1 LYST MAP3K3 MAPK7 MAPT MARK2 MARK4 MDM4 MICALL1 MINK1 MLXIP MPRIP MST1R MTNR1A MTNR1B NCAM2 NEDD4L OSBPL3 PARD3 PARD6B PDCL2 PDE3B PDE4B PI4KB PIK3R2 PIK3R4 PRKCD PRKCG PRKCZ PRPF6 PTPN3 RABGEF1 RACGAP1 RADIL RAF1 RAI14 RALGPS2 RASGRF1 RGS3 RGS7 RIN1 RIOK1 RIPK2 RMDN3 RNPS1 RPS6KA1 SAMSN1 SKP2 SLC4A7 SLC8A1 SLC8A2 SLC8A3 SLC9A1 SNCA SNRNP200 SON SRC SRRM2 SRSF10 SRSF3 STK38 STK38L TESK1 TESK2 TH TJP2 TNFAIP3 TPD52L1 TSC1 TSC2 TUBB UBC UCP2 UCP3 WDR77 WEE1 YWHAE YWHAG ZFP36 ZFP36L1
Entrez ID		9156	7529
HPRD ID		06932	03184
Ensembl ID		ENSG00000174371	ENSG00000166913
Uniprot IDs		A8K5H6 Q9UQ84	P31946 V9HWD6
PDB IDs		3QE9 3QEA 3QEB 5UZV 5V04 5V05 5V06 5V07 5V08 5V09 5V0A 5V0B 5V0C 5V0D 5V0E 7MXQ 7MXR 7MXS 7MXT 7MXU 7MXV 7MXW 7MXX	2BQ0 2C23 4DNK 5N10 6A5Q 6BYK 6GN0 6GN8 6GNJ 6GNK 6GNN 6HEP 8DP5 8EQ8 8EQH
Enriched GO Terms of Interacting Partners?		Mismatch Repair Mismatched DNA Binding Somatic Cell DNA Recombination ATP-dependent DNA Damage Sensor Activity Phosphoserine Residue Binding DNA Recombination Protein Sequestering Activity Dinucleotide Insertion Or Deletion Binding Chromosome Organization Negative Regulation Of DNA Recombination Guanine/thymine Mispair Binding Enzyme Binding Regulation Of DNA Recombination Mismatch Repair Complex Cellular Response To Stress Positive Regulation Of Isotype Switching To IgA Isotypes DNA Metabolic Process DNA Repair Somatic Recombination Of Immunoglobulin Gene Segments Nucleus DNA Damage Response Single-stranded DNA Binding Protein Domain Specific Binding Somatic Diversification Of Immunoglobulins Negative Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Isotype Switching To IgG Isotypes Male Germ Cell Nucleus Somatic Hypermutation Of Immunoglobulin Genes Negative Regulation Of DNA Metabolic Process Somatic Diversification Of Immune Receptors Via Somatic Mutation Regulation Of Isotype Switching To IgG Isotypes Regulation Of DNA Metabolic Process Intracellular Protein Localization Nucleoplasm Chiasma MutSbeta Complex Dinucleotide Repeat Insertion Binding Chromosome, Telomeric Region Positive Regulation Of Hippo Signaling Positive Regulation Of DNA Recombination Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Synaptonemal Complex Protein Kinase C Inhibitor Activity MutLalpha Complex Single Guanine Insertion Binding Response To X-ray Reciprocal Meiotic Recombination Positive Regulation Of Isotype Switching Negative Regulation Of Macromolecule Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process	Kinase Activity Protein Kinase Activity Regulation Of Intracellular Signal Transduction Intracellular Signal Transduction Cytosol Protein Serine Kinase Activity Regulation Of Cell Communication Regulation Of Signaling Protein Serine/threonine Kinase Activity Regulation Of Signal Transduction Positive Regulation Of Cell Communication Cytoplasm Protein Phosphorylation ATP Binding Positive Regulation Of Signaling Negative Regulation Of Signaling Negative Regulation Of Cell Communication Phosphorylation Negative Regulation Of Signal Transduction Regulation Of Programmed Cell Death Regulation Of Apoptotic Process Positive Regulation Of Intracellular Signal Transduction Nucleotide Binding Positive Regulation Of Signal Transduction Regulation Of Protein Metabolic Process Negative Regulation Of Apoptotic Process Negative Regulation Of Intracellular Signal Transduction Negative Regulation Of Programmed Cell Death Regulation Of Protein Modification Process Signal Transduction Cellular Response To Oxygen-containing Compound Protein Tyrosine Kinase Activity Response To Stress Cellular Response To Stress Regulation Of Cell Cycle Regulation Of Membrane Potential Intracellular Signaling Cassette Cellular Response To Hormone Stimulus Cadherin Binding Regulation Of Protein-containing Complex Assembly Regulation Of Phosphorus Metabolic Process Cellular Response To Insulin Stimulus Regulation Of Protein Phosphorylation Regulation Of Biological Quality Plasma Membrane Response To Insulin Positive Regulation Of Catabolic Process Phosphate-containing Compound Metabolic Process Cellular Response To Peptide Hormone Stimulus Regulation Of Phosphorylation
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?