TMEFF1 and FLCN

Number of citations of the paper that reports this interaction (PubMedID 24412244)
0

Data Source:
BioGRID (two hybrid)

		TMEFF1	FLCN
Description		transmembrane protein with EGF like and two follistatin like domains 1	folliculin
Image		No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Membrane	Nucleus Cytoplasm Lysosome Lysosomal Membrane Centrosome Spindle Cytosol Cytoskeleton Plasma Membrane Cilium Membrane Midbody Cell Projection Cell-cell Contact Zone Mitotic Spindle FNIP-folliculin RagC/D GAP
	Molecular Function	Receptor Ligand Inhibitor Activity	Enzyme Inhibitor Activity GTPase Activator Activity Protein Binding Enzyme Binding Protein-containing Complex Binding
	Biological Process	Host-mediated Suppression Of Symbiont Invasion Symbiont Entry Into Host Cell	Negative Regulation Of Transcription By RNA Polymerase II In Utero Embryonic Development Lysosome Organization Cell-cell Junction Assembly Transforming Growth Factor Beta Receptor Signaling Pathway Negative Regulation Of Cell Population Proliferation Cellular Response To Starvation Positive Regulation Of Autophagy Hemopoiesis Positive Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway SCF-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Protein Destabilization Cellular Response To Nutrient Levels TOR Signaling Regulation Of TOR Signaling Negative Regulation Of TOR Signaling Positive Regulation Of TOR Signaling Lysosome Localization Cellular Response To Amino Acid Starvation Negative Regulation Of Rho Protein Signal Transduction Intracellular Signal Transduction TORC1 Signaling Positive Regulation Of Apoptotic Process Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Negative Regulation Of Glycolytic Process Negative Regulation Of DNA-templated Transcription Regulation Of Ras Protein Signal Transduction Epithelial Cell Proliferation Negative Regulation Of Epithelial Cell Proliferation Negative Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction ERK1 And ERK2 Cascade Negative Regulation Of ERK1 And ERK2 Cascade Cell Proliferation Involved In Kidney Development Energy Homeostasis Intrinsic Apoptotic Signaling Pathway Negative Regulation Of Cold-induced Thermogenesis Negative Regulation Of Protein Localization To Nucleus Negative Regulation Of Cell Proliferation Involved In Kidney Development Negative Regulation Of Post-translational Protein Modification Negative Regulation Of Intracellular Signal Transduction Negative Regulation Of Brown Fat Cell Differentiation Positive Regulation Of TORC1 Signaling Negative Regulation Of Lysosome Organization Regulation Of Pro-B Cell Differentiation Positive Regulation Of Intrinsic Apoptotic Signaling Pathway
Pathways			Amino acids regulate mTORC1
Drugs
Diseases			Birt-Hogg-Dube syndrome Renal cell carcinoma
GWAS		Aspartate aminotransferase levels ( 33547301) Familial squamous cell lung carcinoma ( 29924316)	Heel bone mineral density ( 30598549) Mean reticulocyte volume ( 32888494)
Interacting Genes		10 interacting genes: APC BUB1 CCR1 CDKN2A DLC1 DYRK1A FLCN MLH3 PTEN PTPRJ	12 interacting genes: ALDOB APP CCDC180 FBP1 GABARAP HEMGN HSP90AA1 MAP1LC3B NANS RRAGA TMEFF1 TSTD2
Entrez ID		8577	201163
HPRD ID		04570	06278
Ensembl ID		ENSG00000241697	ENSG00000154803
Uniprot IDs		Q8IYR6	A0A0S2Z5Y7 Q8NFG4
PDB IDs			3V42 6NZD 6ULG 8DHB
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Phosphate Metabolic Process Negative Regulation Of Protein Phosphorylation Negative Regulation Of Phosphorylation Regulation Of Cell-matrix Adhesion Negative Regulation Of Cellular Component Organization Negative Regulation Of Protein Serine/threonine Kinase Activity Negative Regulation Of Cell Population Proliferation Negative Regulation Of Cell-matrix Adhesion Regulation Of Cell-substrate Adhesion Negative Regulation Of Cell-substrate Adhesion Regulation Of Cellular Component Organization Negative Regulation Of Kinase Activity Negative Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Regulation Of Phosphorus Metabolic Process Cell Junction Assembly Negative Regulation Of Protein Kinase Activity Negative Regulation Of Protein Metabolic Process Regulation Of Cell-substrate Junction Organization Regulation Of Focal Adhesion Assembly Negative Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Intracellular Signal Transduction Regulation Of Protein Modification Process Negative Regulation Of Cyclin-dependent Protein Kinase Activity Gamma-catenin Binding Ruffle Membrane Beta-catenin Binding Regulation Of Intracellular Signal Transduction Regulation Of Mitotic Cell Cycle Phase Transition Regulation Of Signal Transduction Negative Regulation Of Cell Cycle Negative Regulation Of Intracellular Signal Transduction Regulation Of Protein Serine/threonine Kinase Activity Negative Regulation Of Signal Transduction Regulation Of Protein Phosphorylation Negative Regulation Of Focal Adhesion Assembly Regulation Of Phosphorylation Negative Regulation Of Cell Communication Regulation Of Protein Metabolic Process Negative Regulation Of Signaling Negative Regulation Of Rho Protein Signal Transduction Negative Regulation Of Cytoskeleton Organization Regulation Of Cell Communication Regulation Of Cell Cycle Phase Transition Regulation Of Signaling Negative Regulation Of Supramolecular Fiber Organization Negative Regulation Of Catalytic Activity Cell Junction Organization Regulation Of G1/S Transition Of Mitotic Cell Cycle Negative Regulation Of Mitotic Cell Cycle Phase Transition Regulation Of Cell Migration	Fructose Metabolic Process Regulation Of Carbohydrate Catabolic Process Fructose 1,6-bisphosphate Metabolic Process Regulation Of Purine Nucleotide Metabolic Process Ubiquitin Protein Ligase Binding Autophagosome Organization Autophagosome Assembly Phosphatidylethanolamine Binding Cellular Response To Nitrogen Starvation Carbohydrate Biosynthetic Process Response To Salt Stress Regulation Of Generation Of Precursor Metabolites And Energy Vacuole Organization Response To Nutrient Levels Cellular Response To Starvation Positive Regulation Of Nitric Oxide Biosynthetic Process Positive Regulation Of Protein Catabolic Process Positive Regulation Of Nitric Oxide Metabolic Process Gluconeogenesis Hexose Biosynthetic Process Fructose-1-phosphate Aldolase Activity Amyloid-beta Complex Growth Cone Lamellipodium Regulation Of Response To Calcium Ion Regulation Of Glycolytic Process Amylin Binding Positive Regulation Of Toll Signaling Pathway Cellular Response To CAMP CTP Binding DATP Binding Response To Starvation Cellular Response To Nutrient Levels Autophagosome Membrane Autophagosome Maturation N-acetylneuraminate Synthase Activity N-acylneuraminate-9-phosphate Synthase Activity Mitophagy Regulation Of Nitric Oxide Biosynthetic Process Regulation Of Nitric Oxide Metabolic Process Autophagy Regulation Of Small Molecule Metabolic Process Negative Regulation Of Pentose-phosphate Shunt Acetylcholine Receptor Activator Activity Regulation Of ATP Metabolic Process Lipoprotein Particle Positive Regulation Of Protein Import Response To Osmotic Stress Phosphoric Ester Hydrolase Activity Cellular Response To Raffinose Fructose 1,6-bisphosphate 1-phosphatase Activity
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