GALNT12 and MUC2

Number of citations of the paper that reports this interaction (PMID 12135769)
12

Data Source:
HPRD (in vitro)

		GALNT12	MUC2
Gene Name		polypeptide N-acetylgalactosaminyltransferase 12	mucin 2, oligomeric mucus/gel-forming
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Golgi Membrane Integral Component Of Membrane	Golgi Lumen Inner Mucus Layer Outer Mucus Layer
	Molecular Function	Polypeptide N-acetylgalactosaminyltransferase Activity Carbohydrate Binding Metal Ion Binding	Protein Binding
	Biological Process	Protein O-linked Glycosylation O-glycan Processing Post-translational Protein Modification Cellular Protein Metabolic Process	Protein O-linked Glycosylation O-glycan Processing Maintenance Of Gastrointestinal Epithelium Post-translational Protein Modification Cellular Protein Metabolic Process
Pathways		Post-translational protein modification O-linked glycosylation of mucins O-linked glycosylation	Post-translational protein modification Termination of O-glycan biosynthesis O-linked glycosylation of mucins O-linked glycosylation
Drugs			Pranlukast
Diseases
GWAS			Interstitial lung disease ( 23583980)
Protein-Protein Interactions		5 interactors: APP MUC1 MUC2 MUC5AC MUC7	4 interactors: GALNT12 GALNT14 MLH1 PLEKHM1
Entrez ID		79695	4583
HPRD ID		13561	11828
Ensembl ID		ENSG00000119514	ENSG00000198788
Uniprot IDs		Q8IXK2	Q02817
PDB IDs
Enriched GO Terms of Interacting Partners?		O-glycan Processing Protein O-linked Glycosylation Post-translational Protein Modification Protein Glycosylation Macromolecule Glycosylation Glycosylation Glycoprotein Biosynthetic Process Glycoprotein Metabolic Process Carbohydrate Metabolic Process Cellular Protein Modification Process Cellular Protein Metabolic Process Synaptic Growth At Neuromuscular Junction Collateral Sprouting In Absence Of Injury Protein Metabolic Process Regulation Of Mitotic Cell Cycle Phase Transition Positive Regulation Of Cell Cycle Process Regulation Of Cell Cycle Phase Transition Collateral Sprouting Axon Midline Choice Point Recognition Smooth Endoplasmic Reticulum Calcium Ion Homeostasis Axon Choice Point Recognition Positive Regulation Of Cell Cycle Positive Regulation Of Histone H4 Acetylation Negative Regulation Of Transcription By Competitive Promoter Binding Neuron Remodeling Extracellular Matrix Organization Extracellular Structure Organization Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Negative Regulation Of Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage By P53 Class Mediator DNA Damage Response, Signal Transduction By P53 Class Mediator Resulting In Transcription Of P21 Class Mediator Extracellular Fibril Organization Regulation Of Cellular Amino Acid Metabolic Process DNA Damage Response, Signal Transduction Resulting In Transcription Regulation Of Mitotic Cell Cycle Negative Regulation Of Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator Positive Regulation Of Transcription From RNA Polymerase II Promoter In Response To Stress Maintenance Of Gastrointestinal Epithelium Regulation Of Histone H4 Acetylation Cellular Copper Ion Homeostasis Regulation Of Cell Cycle Process Epithelial Structure Maintenance Regulation Of Cellular Ketone Metabolic Process Regulation Of Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator Positive Regulation Of Histone Acetylation Copper Ion Homeostasis Suckling Behavior Negative Regulation Of Signal Transduction By P53 Class Mediator Positive Regulation Of Peptidyl-lysine Acetylation Positive Regulation Of G2/M Transition Of Mitotic Cell Cycle	O-glycan Processing Protein O-linked Glycosylation Meiotic Spindle Midzone Assembly Meiotic Metaphase I Plate Congression Negative Regulation Of Mitotic Recombination Post-translational Protein Modification Regulation Of Mitotic Recombination Male Meiosis Chromosome Segregation Macromolecule Glycosylation Protein Glycosylation Glycosylation Spindle Midzone Assembly Glycoprotein Biosynthetic Process Resolution Of Meiotic Recombination Intermediates Glycoprotein Metabolic Process Somatic Hypermutation Of Immunoglobulin Genes Somatic Diversification Of Immune Receptors Via Somatic Mutation Double-strand Break Repair Via Nonhomologous End Joining Chromosome Separation Negative Regulation Of DNA Recombination Nuclear-transcribed MRNA Poly(A) Tail Shortening Isotype Switching Metaphase Plate Congression Somatic Recombination Of Immunoglobulin Gene Segments Somatic Diversification Of Immunoglobulins Establishment Of Chromosome Localization Immunoglobulin Production Involved In Immunoglobulin Mediated Immune Response Reciprocal Meiotic Recombination B Cell Activation Involved In Immune Response Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay Synapsis Mismatch Repair Homologous Chromosome Segregation Male Meiosis Immunoglobulin Production Carbohydrate Metabolic Process Regulation Of DNA Recombination Oogenesis MRNA 3'-end Processing Meiotic Chromosome Segregation Spindle Assembly Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Negative Regulation Of DNA Metabolic Process
Tagcloud ?		abnormality defect disrupting ectopic endoplasmic enhances glycoproteins glycosylation h3k4 h6pd hrx leukemogenesis lineage mammals maturation mef methyltransferase mll1 named promoters restore subject tm trimethylation tunicamycin ugp2 unfolded unsolved upr	barrett cdx1 columnar dnmaml esophagus formerly goblet hes1 jag1 k13 k14 k18 k19 k20 k5 k8 keratins klf4 mastermind metaplasia muc17 muc3b muc5b mucins notch notch2 notch3 organotypic transdifferentiation
Tagcloud (Difference) ?		abnormality defect disrupting ectopic endoplasmic enhances glycoproteins glycosylation h3k4 h6pd hrx leukemogenesis lineage mammals maturation mef methyltransferase mll1 named promoters restore subject tm trimethylation tunicamycin ugp2 unfolded unsolved upr	barrett cdx1 columnar dnmaml esophagus formerly goblet hes1 jag1 k13 k14 k18 k19 k20 k5 k8 keratins klf4 mastermind metaplasia muc17 muc3b muc5b mucins notch notch2 notch3 organotypic transdifferentiation
Tagcloud (Intersection) ?