MSH5 and MSH4

Number of citations of the paper that reports this interaction (PMID 10029069)
19

Data Source:
HPRD (in vitro, two hybrid)

		MSH5	MSH4
Gene Name		mutS homolog 5	mutS homolog 4
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Synaptonemal Complex Mismatch Repair Complex	Synaptonemal Complex Nucleus Mismatch Repair Complex
	Molecular Function	Damaged DNA Binding Protein Binding ATP Binding DNA-dependent ATPase Activity Mismatched DNA Binding	DNA Binding Damaged DNA Binding Protein Binding ATP Binding DNA-dependent ATPase Activity Mismatched DNA Binding
	Biological Process	Meiotic Mismatch Repair Reciprocal Meiotic Recombination Homologous Chromosome Segregation Chiasma Assembly	Meiotic Mismatch Repair Ovarian Follicle Development Reciprocal Meiotic Recombination Spermatogenesis Female Gamete Generation Homologous Chromosome Segregation Chiasma Assembly
Pathways		Meiotic recombination	Meiotic recombination
Drugs
Diseases
GWAS		Lung cancer ( 18978787)
Protein-Protein Interactions		1 interactors: MSH4	5 interactors: MLH1 MLH3 MSH5 RPA1 VBP1
Entrez ID		4439	4438
HPRD ID		04544	03658
Ensembl ID		ENSG00000204410	ENSG00000057468
Uniprot IDs		O43196	O15457
PDB IDs
Enriched GO Terms of Interacting Partners?		Chiasma Assembly Reciprocal Meiotic Recombination Synapsis Homologous Chromosome Segregation Ovarian Follicle Development Meiotic Chromosome Segregation Ovulation Cycle Process Meiosis I Female Gonad Development Female Gamete Generation Ovulation Cycle Development Of Primary Female Sexual Characteristics Meiotic Nuclear Division Meiotic Cell Cycle Chromosome Segregation Gonad Development DNA Recombination Development Of Primary Sexual Characteristics Sex Differentiation Rhythmic Process Reproductive Structure Development Reproductive System Development Spermatogenesis Male Gamete Generation	Mismatch Repair Meiotic Nuclear Division Meiotic Cell Cycle Reciprocal Meiotic Recombination DNA Recombination Synapsis Homologous Chromosome Segregation Meiotic Chromosome Segregation Meiosis I DNA Repair Cellular Response To DNA Damage Stimulus Chromosome Segregation Chromosome Organization Reproduction Cell Cycle Process DNA Metabolic Process Cell Cycle Male Meiosis Cellular Response To Stress Cellular Component Assembly Meiotic Spindle Midzone Assembly Meiotic Metaphase I Plate Congression Double-strand Break Repair Negative Regulation Of Mitotic Recombination Regulation Of Mitotic Recombination Male Meiosis Chromosome Segregation DNA Recombinase Assembly Organelle Organization Chiasma Assembly Spindle Midzone Assembly Response To Stress Female Meiosis I Resolution Of Meiotic Recombination Intermediates Somatic Hypermutation Of Immunoglobulin Genes Somatic Diversification Of Immune Receptors Via Somatic Mutation Aromatic Compound Catabolic Process Nucleotide-excision Repair, DNA Gap Filling Nucleotide-excision Repair, DNA Damage Removal Telomere Maintenance Via Semi-conservative Replication Synaptonemal Complex Assembly Double-strand Break Repair Via Nonhomologous End Joining Chromosome Separation Negative Regulation Of DNA Recombination Synaptonemal Complex Organization Nuclear DNA Replication Telomere Maintenance Via Recombination Nuclear-transcribed MRNA Poly(A) Tail Shortening Isotype Switching Nucleobase-containing Compound Metabolic Process Mitotic Recombination
Tagcloud ?		aggregated anaplastic atc braf cdkn1b cdkn2c ctnnb1 eif1ax exclusive exome harbored hypermutator landscape mismatch mlh mlh1 mlh3 msh6 mutational mutually nf1 nf2 nras ontology pik3ca ret unresponsive ush2a v600e	2480delg 2480t 286c anaplastic astrocytomas codon contributed exceptionally exome fraumeni germline glioblastomas gliomas i827n inherited lats1 li missense mutational neurofibroma nf2 r827kfs r96w schwannoma schwannomas schwannomatosis sporadic stop tp53
Tagcloud (Difference) ?		aggregated atc braf cdkn1b cdkn2c ctnnb1 eif1ax exclusive harbored hypermutator landscape mismatch mlh mlh1 mlh3 msh6 mutually nf1 nras ontology pik3ca ret unresponsive ush2a v600e	2480delg 2480t 286c astrocytomas codon contributed exceptionally fraumeni germline glioblastomas gliomas i827n inherited lats1 li missense neurofibroma r827kfs r96w schwannoma schwannomas schwannomatosis sporadic stop tp53
Tagcloud (Intersection) ?		anaplastic exome mutational nf2