MSH5 and MSH4

Number of citations: 0 (PubMedID 9787078)
Data Source: HPRD (two hybrid, in vitro)

		MSH5	MSH4
Name		mutS homolog 5	mutS homolog 4
Structure		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Nucleus	Condensed Chromosome Condensed Nuclear Chromosome Synaptonemal Complex Nucleus Chromosome Recombination Nodule
	Molecular Function	Nucleotide Binding DNA Binding Double-stranded DNA Binding Protein Binding ATP Binding Mismatched DNA Binding ATP-dependent DNA Damage Sensor Activity	Nucleotide Binding DNA Binding Double-stranded DNA Binding Protein Binding ATP Binding Mismatched DNA Binding ATP-dependent DNA Damage Sensor Activity
	Biological Process	DNA Repair Mismatch Repair DNA Damage Response Meiosis I Chiasma Assembly Meiotic Cell Cycle	Ovarian Follicle Development Mismatch Repair Homologous Chromosome Pairing At Meiosis Reciprocal Meiotic Recombination Spermatogenesis Female Gamete Generation Meiotic Cell Cycle
Pathways		Meiotic recombination	Meiotic recombination
GWAS		A body shape index ( 34021172 ) Asthma ( 31619474 ) Asthma (childhood onset) ( 31619474 ) Asthma and major depressive disorder ( 31619474 ) Autism spectrum disorder or schizophrenia ( 28540026 ) Blond vs. brown/black hair color ( 30531825 ) Clozapine-induced agranulocytosis/granulocytopenia in treatment-resistant schizophrenia ( 26876947 ) Cutaneous lupus erythematosus ( 25827949 ) Hip circumference adjusted for BMI ( 34021172 ) Inflammatory bowel disease ( 28067908 ) Lung cancer ( 18978787 ) Mastocytosis ( 32752121 ) Medication use (anilides) ( 31015401 ) Menopause (age at onset) ( 26414677 ) Pulse pressure ( 27618448 ) Systemic lupus erythematosus ( 26316170 ) Systemic mastocytosis ( 32752121 ) Systolic blood pressure ( 27618448 ) Takayasu arteritis ( 25604533 ) Ulcerative colitis ( 28067908 24837172 )	Attention function in attention deficit hyperactive disorder ( 26174813 ) Daytime sleep phenotypes ( 27126917 ) Gut microbiota (bacterial taxa, hurdle binary method) ( 32572223 ) Serum metabolite levels ( 23093944 )
Interacting Genes		4 interacting genes: MLH1 MLH3 MSH4 TRIM54	9 interacting genes: CFTR DMC1 EIF3F MLH1 MLH3 MSH5 RAD51 RPA1 VBP1
Entrez ID		4439	4438
HPRD ID		04544	03658
Ensembl ID		ENSG00000204410	ENSG00000057468
Uniprot IDs		A0A024RCM1 O43196	O15457
PDB IDs		Not available	Not available
GO Terms Enriched among Interactors		Mismatched DNA Binding ATP-dependent DNA Damage Sensor Activity Mismatch Repair Reciprocal Meiotic Recombination Chiasma Synaptonemal Complex Condensed Chromosome Homologous Recombination Condensed Nuclear Chromosome Chromosome Organization Involved In Meiotic Cell Cycle Mismatch Repair Complex Homologous Chromosome Pairing At Meiosis DNA Recombination Male Meiotic Nuclear Division Male Germ Cell Nucleus Chromosome Organization Female Gamete Generation Meiosis I Cell Cycle Process Meiotic Nuclear Division Late Recombination Nodule Meiotic Metaphase I Homologous Chromosome Alignment Recombination Nodule Nuclear Division Reproductive Process DNA Repair Meiotic Cell Cycle Meiotic Spindle Midzone Assembly Meiotic Metaphase Chromosome Alignment Alpha-sialidase Activity Male Meiosis Chromosome Segregation MutLalpha Complex DNA Metabolic Process Guanine/thymine Mispair Binding Negative Regulation Of Mitotic Recombination Exo-alpha-sialidase Activity Satellite DNA Binding DNA Damage Response Homologous Chromosome Segregation Female Meiosis Chromosome Segregation Luteolysis Positive Regulation Of Isotype Switching To IgA Isotypes Centromeric DNA Binding MutSalpha Complex Binding Regulation Of Mitotic Recombination Positive Regulation Of Transcription Of Notch Receptor Target Female Meiosis I Meiotic Telomere Clustering Chromosome Localization To Nuclear Envelope Involved In Homologous Chromosome Segregation Ganglioside Catabolic Process Telomere Localization	ATP-dependent DNA Damage Sensor Activity Condensed Nuclear Chromosome Meiosis I Cell Cycle Process Meiotic Nuclear Division Nuclear Division Reciprocal Meiotic Recombination Mismatch Repair Condensed Chromosome Meiotic Cell Cycle Homologous Recombination Meiosis I Male Germ Cell Nucleus Chromosome Organization Involved In Meiotic Cell Cycle Mismatched DNA Binding Lateral Element DNA Recombination DNA Repair Chiasma DNA Strand Exchange Activity Single-stranded DNA Binding Chromosome Organization DNA Metabolic Process DNA Damage Response Reproductive Process Male Meiotic Nuclear Division Mismatch Repair Complex DNA Strand Invasion DNA Recombinase Assembly Cellular Response To Stress Double-strand Break Repair Double-strand Break Repair Involved In Meiotic Recombination Site Of Double-strand Break Response To Stress ATP Binding Double-stranded DNA Binding Mitotic Recombination Double-strand Break Repair Via Homologous Recombination Recombinational Repair Synaptonemal Complex Cellular Component Assembly Homologous Chromosome Pairing At Meiosis Chromatin Binding Chromosome, Telomeric Region Telomere Maintenance Via Telomere Lengthening Nuclear Chromosome ATP-dependent Activity, Acting On DNA Oogenesis Nucleic Acid Metabolic Process Intracellularly ATP-gated Chloride Channel Activity Positive Regulation Of Voltage-gated Chloride Channel Activity