AKAP8L and CDC6

Number of citations of the paper that reports this interaction (PMID 12538639)
13

Data Source:
HPRD (in vivo)

		AKAP8L	CDC6
Gene Name		A kinase (PRKA) anchor protein 8-like	cell division cycle 6
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Nuclear Matrix	Spindle Pole Nucleus Nucleoplasm Cytoplasm Golgi Apparatus Cytosol Spindle Midzone
	Molecular Function	DNA Binding Protein Binding DEAD/H-box RNA Helicase Binding Poly(A) RNA Binding Metal Ion Binding	Nucleotide Binding Chromatin Binding Protein Binding ATP Binding Kinase Binding
	Biological Process	Biological_process	DNA Replication Checkpoint Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity G1/S Transition Of Mitotic Cell Cycle Regulation Of Transcription Involved In G1/S Transition Of Mitotic Cell Cycle Mitotic Cell Cycle DNA Replication Mitotic Nuclear Division Traversing Start Control Point Of Mitotic Cell Cycle Negative Regulation Of DNA Replication Negative Regulation Of Cell Proliferation Regulation Of Mitotic Metaphase/anaphase Transition Positive Regulation Of Cytokinesis Cell Division Positive Regulation Of Chromosome Segregation
Pathways			CDK-mediated phosphorylation and removal of Cdc6 G2/M Checkpoints Activation of the pre-replicative complex Activation of the pre-replicative complex Orc1 removal from chromatin CDK-mediated phosphorylation and removal of Cdc6 Assembly of the pre-replicative complex Activation of ATR in response to replication stress G1/S Transition G1/S-Specific Transcription Removal of licensing factors from origins Mitotic G1-G1/S phases Switching of origins to a post-replicative state E2F mediated regulation of DNA replication Synthesis of DNA DNA Replication Pre-Initiation Regulation of DNA replication M/G1 Transition G0 and Early G1 S Phase CDC6 association with the ORC:origin complex Cell Cycle, Mitotic Orc1 removal from chromatin Cell Cycle Checkpoints CDT1 association with the CDC6:ORC:origin complex Association of licensing factors with the pre-replicative complex
Drugs
Diseases
GWAS
Protein-Protein Interactions		7 interactors: CDC6 DHX9 EMD LBR PRKACA PRPF40A TMPO	36 interactors: AKAP8L ATM ATRIP B3GALNT1 CCNA2 CCNB1 CCNE1 CDC14A CDC20 CDK1 CDK2 CDK4 CDK6 CDKN1A CDKN2A CDT1 FZR1 KAT7 MCM10 MCM2 MCM3 MCM7 MYC ORC1 ORC2 ORC3 ORC5 ORC6 PCNA PPP2R3A PPP2R3B PSKH1 RPS27A TERF1 UBE2K UBR1
Entrez ID		26993	990
HPRD ID		10641	04022
Ensembl ID		ENSG00000011243	ENSG00000094804
Uniprot IDs		Q9ULX6	Q99741
PDB IDs			2CCH 2CCI 4I5L 4I5N
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Protein Export From Nucleus Regulation Of Protein Export From Nucleus Mitotic Nuclear Envelope Disassembly Nuclear Envelope Disassembly Regulation Of Cytokinesis Nuclear Envelope Organization Regulation Of Cell Cycle Process Positive Regulation Of Dense Core Granule Biogenesis Cell Cycle Positive Regulation Of Nucleocytoplasmic Transport Positive Regulation Of Mitotic Cell Cycle Nucleus Organization Histone H3-T6 Phosphorylation Organelle Organization Negative Regulation Of Cell Proliferation Mitotic Cell Cycle Process Positive Regulation Of Intracellular Protein Transport Mitotic Cell Cycle Traversing Start Control Point Of Mitotic Cell Cycle CRD-mediated MRNA Stabilization Regulation Of Proteasomal Protein Catabolic Process Regulation Of Nucleocytoplasmic Transport Positive Regulation Of Cell Cycle Process Regulation Of Cell Cycle Peptidyl-serine Autophosphorylation Positive Regulation Of Lipopolysaccharide-mediated Signaling Pathway Cellular Response To Parathyroid Hormone Stimulus Negative Regulation Of Smoothened Signaling Pathway Involved In Dorsal/ventral Neural Tube Patterning Positive Regulation Of Intracellular Transport Regulation Of Cell Division Mitotic Cell Cycle Phase Transition Regulation Of Intracellular Protein Transport Cell Cycle Phase Transition Cell Cycle Process Desmosome Assembly Mitotic Nuclear Envelope Reassembly Negative Regulation Of Glial Cell Apoptotic Process Positive Regulation Of Cell Cycle Regulation Of Tight Junction Assembly DNA Replication Checkpoint Negative Regulation Of Catenin Import Into Nucleus Negative Regulation Of Glucose Import Positive Regulation Of Macrophage Differentiation Nuclear Envelope Reassembly Cell Communication By Electrical Coupling Involved In Cardiac Conduction Calcium-mediated Signaling Using Intracellular Calcium Source Desmosome Organization Response To Parathyroid Hormone Positive Regulation Of Protein Transport Cell Communication By Electrical Coupling	G1/S Transition Of Mitotic Cell Cycle Mitotic Cell Cycle Phase Transition Cell Cycle Phase Transition Mitotic Cell Cycle Process Mitotic Cell Cycle Cell Cycle Process Cell Cycle DNA Replication DNA Metabolic Process Regulation Of Cell Cycle DNA Replication Initiation Cell Cycle Checkpoint DNA-dependent DNA Replication Negative Regulation Of Cell Cycle Cell Division Cellular Metabolic Process Regulation Of Cell Cycle Process Regulation Of Mitotic Cell Cycle Regulation Of Mitotic Cell Cycle Phase Transition DNA Damage Checkpoint Regulation Of Cell Cycle Phase Transition Regulation Of Ubiquitin-protein Transferase Activity Mitotic Cell Cycle Checkpoint Regulation Of Transcription Involved In G1/S Transition Of Mitotic Cell Cycle Positive Regulation Of Cell Cycle G2/M Transition Of Mitotic Cell Cycle Regulation Of Ubiquitin-protein Ligase Activity Involved In Mitotic Cell Cycle Positive Regulation Of Fibroblast Proliferation Anaphase-promoting Complex-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Chromosome Organization Negative Regulation Of Mitotic Cell Cycle Cellular Response To Stress Cellular Response To DNA Damage Stimulus Cellular Protein Modification Process Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Regulation Of Protein Catabolic Process Nucleobase-containing Compound Metabolic Process Mitotic DNA Damage Checkpoint Regulation Of Fibroblast Proliferation Regulation Of Cell Cycle Arrest Mitotic DNA Integrity Checkpoint Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Regulation Of Protein Ubiquitination Regulation Of Protein Metabolic Process Cellular Nitrogen Compound Metabolic Process Positive Regulation Of Ubiquitin-protein Ligase Activity Involved In Regulation Of Mitotic Cell Cycle Transition Regulation Of Proteolysis Positive Regulation Of Cell Cycle Process
Tagcloud ?			antiserum cdc18p cdc6p cerevisiae cloning cooperates cotransfection downregulating dsc1 e2f enter eukaryotes exponentially footprinting hcdc6 homolog mbf microinjection multicellular occupied pombe prb prereplication replication resting saccharomyces sbf schizosaccharomyces timed
Tagcloud (Difference) ?			antiserum cdc18p cdc6p cerevisiae cloning cooperates cotransfection downregulating dsc1 e2f enter eukaryotes exponentially footprinting hcdc6 homolog mbf microinjection multicellular occupied pombe prb prereplication replication resting saccharomyces sbf schizosaccharomyces timed
Tagcloud (Intersection) ?