AKAP8L and PTP4A2

Number of citations of the paper that reports this interaction (PubMedID 36300783)
81

Data Source:
BioGRID (pull down)

		AKAP8L	PTP4A2
Description		A-kinase anchoring protein 8 like	protein tyrosine phosphatase 4A2
Image		No pdb structure
GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm Cytoplasm Nuclear Matrix PML Body Nuclear Speck Ribonucleoprotein Complex	Nucleus Cytoplasm Endosome Early Endosome Cytosol Plasma Membrane Membrane
	Molecular Function	DNA Binding RNA Binding Protein Binding Lamin Binding Zinc Ion Binding DEAD/H-box RNA Helicase Binding Protein Kinase A Regulatory Subunit Binding Histone Deacetylase Binding Metal Ion Binding	Phosphoprotein Phosphatase Activity Protein Tyrosine Phosphatase Activity Enzyme Inhibitor Activity Protein Binding Hydrolase Activity
	Biological Process	MRNA Processing Mitotic Chromosome Condensation RNA Splicing Regulation Of MRNA Export From Nucleus Cell Cycle G2/M Phase Transition Positive Regulation Of Transcription By RNA Polymerase II Nuclear Membrane Disassembly
Pathways		Formation of WDR5-containing histone-modifying complexes	RAB geranylgeranylation
Drugs
Diseases
GWAS		Red blood cell count ( 32888494)	Appendicular lean mass ( 33097823) Body mass index ( 26426971)
Interacting Genes		60 interacting genes: ABI2 ATOSB ATPAF2 CARHSP1 CATSPER1 CCDC120 CCDC24 CDC6 CNNM3 CREB5 CSTF2 CSTF2T DGCR6 DHX9 DMRT3 DSCR9 EMD ENKD1 FOXD4 GPANK1 GPS2 HEMK1 HGS HSF4 HUNK INCA1 KPRP LAGE3 LBR MYOZ1 MYPOP PATZ1 PCDHB14 PEF1 PITX1 PLEKHN1 PRKAA2 PRKACA PRPF40A PTP4A2 RAMAC RTP5 RUSC1 SAMD4A SAXO1 SAXO4 SH3RF2 SNRPC TEKT4 TEKT5 TENT5B TFAP2D TIAL1 TLE5 TMPO TMSB4X TRIB3 TSGA10IP WDR25 ZNF366	13 interacting genes: AKAP8L ATF7 CARS1 CNNM1 CNNM3 DHX15 DUSP22 EWSR1 HSP90AA1 HSP90AB1 MPO RABGGTB WIPF2
Entrez ID		26993	8073
HPRD ID		10641	03348
Ensembl ID		ENSG00000011243	ENSG00000184007
Uniprot IDs		Q9ULX6	Q12974
PDB IDs			5K22 5K23 5K25 6WUR
Enriched GO Terms of Interacting Partners?		Protein Binding Sperm Flagellum	Nitric-oxide Synthase Regulator Activity Dendritic Growth Cone TPR Domain Binding Telomerase Holoenzyme Complex Assembly Magnesium Ion Homeostasis Axonal Growth Cone Chaperone-mediated Protein Complex Assembly RNA-templated DNA Biosynthetic Process MHC Class II Protein Complex Binding Telomere Maintenance Via Telomerase Histone Deacetylase Binding Disordered Domain Specific Binding DNA Polymerase Binding Telomere Maintenance Via Telomere Lengthening Protein Folding Chaperone Complex ATP-dependent Protein Folding Chaperone Positive Regulation Of Nitric Oxide Biosynthetic Process Positive Regulation Of Nitric Oxide Metabolic Process Protein Tyrosine Kinase Binding Tau Protein Binding CTP Binding DATP Binding Cellular Response To Heat Hypochlorous Acid Biosynthetic Process Protein Folding Chaperone Regulation Of Nitric Oxide Biosynthetic Process Regulation Of Nitric Oxide Metabolic Process Cysteine-tRNA Ligase Activity Cysteinyl-tRNA Aminoacylation Double-stranded RNA Binding Neurofibrillary Tangle Assembly UTP Binding Sulfonylurea Receptor Binding HSP90-CDC37 Chaperone Complex Response To Gold Nanoparticle U2-type Post-mRNA Release Spliceosomal Complex Response To Alkaloid DNA Biosynthetic Process Response To Unfolded Protein Rho GDP-dissociation Inhibitor Binding Chromosome Organization Response To Heat Neuronal Cell Body Response To Transition Metal Nanoparticle Leading Edge Of Lamellipodium ATP Hydrolysis Activity Telomere Maintenance Melanosome Phagocytic Vesicle Lumen Rab-protein Geranylgeranyltransferase Complex
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