AKAP8L and DHX9

Number of citations of the paper that reports this interaction (PMID 10748171)
9

Data Source:
HPRD (in vitro, in vivo, two hybrid)

		AKAP8L	DHX9
Gene Name		A kinase (PRKA) anchor protein 8-like	DEAH (Asp-Glu-Ala-His) box helicase 9
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Nuclear Matrix	Nucleus Nucleoplasm Nucleolus Cytoplasm Centrosome Cytosol Membrane Ribonucleoprotein Complex Cytoplasmic Ribonucleoprotein Granule CRD-mediated MRNA Stability Complex
	Molecular Function	DNA Binding Protein Binding DEAD/H-box RNA Helicase Binding Poly(A) RNA Binding Metal Ion Binding	RNA Polymerase II Transcription Factor Binding DNA Binding RNA Helicase Activity ATP-dependent DNA Helicase Activity ATP-dependent RNA Helicase Activity Protein Binding ATP Binding Poly(A) RNA Binding
	Biological Process	Biological_process	MRNA Splicing, Via Spliceosome Osteoblast Differentiation RNA Processing Circadian Rhythm RNA Splicing Gene Expression Positive Regulation Of Type I Interferon Production DNA Duplex Unwinding Cellular Response To Heat Innate Immune Response CRD-mediated MRNA Stabilization
Pathways			mRNA Splicing Toll Like Receptor 7/8 (TLR7/8) Cascade Toll Like Receptor TLR6:TLR2 Cascade RIP-mediated NFkB activation via ZBP1 DEx/H-box helicases activate type I IFN and inflammatory cytokines production Toll Like Receptor TLR1:TLR2 Cascade Activated TLR4 signalling MyD88 cascade initiated on plasma membrane Toll Like Receptor 5 (TLR5) Cascade ZBP1(DAI) mediated induction of type I IFNs MyD88 dependent cascade initiated on endosome MyD88:Mal cascade initiated on plasma membrane TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation Toll Like Receptor 9 (TLR9) Cascade Innate Immune System Processing of Capped Intron-Containing Pre-mRNA TRIF-mediated TLR3/TLR4 signaling Cytosolic sensors of pathogen-associated DNA mRNA Splicing - Major Pathway MyD88-independent cascade Toll Like Receptor 2 (TLR2) Cascade RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways Toll-Like Receptors Cascades Toll Like Receptor 10 (TLR10) Cascade Toll Like Receptor 4 (TLR4) Cascade Toll Like Receptor 3 (TLR3) Cascade TRAF6 mediated NF-kB activation TAK1 activates NFkB by phosphorylation and activation of IKKs complex
Drugs
Diseases
GWAS
Protein-Protein Interactions		7 interactors: CDC6 DHX9 EMD LBR PRKACA PRPF40A TMPO	40 interactors: ACTA1 AKAP8L APBB1 BRCA1 DDX20 DDX5 EIF2AK2 EWSR1 GEMIN2 GEMIN4 GTF2B H2AFX HDLBP HNRNPC HNRNPK IL7R ILF3 JUN KHDRBS1 MBD2 MGEA5 NXF1 PCNA POLR2A PRMT1 PRPF40A PRPF8 RBM4 RELA SMN1 SMN2 SNRPB SNRPB2 SRPK1 SSRP1 STAU1 TBP TOP2A UBE2I YWHAQ
Entrez ID		26993	1660
HPRD ID		10641	04386
Ensembl ID		ENSG00000011243	ENSG00000135829
Uniprot IDs		Q9ULX6	B3KU66 Q08211
PDB IDs			3LLM 3VYX 3VYY
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Protein Export From Nucleus Regulation Of Protein Export From Nucleus Mitotic Nuclear Envelope Disassembly Nuclear Envelope Disassembly Regulation Of Cytokinesis Nuclear Envelope Organization Regulation Of Cell Cycle Process Positive Regulation Of Dense Core Granule Biogenesis Cell Cycle Positive Regulation Of Nucleocytoplasmic Transport Positive Regulation Of Mitotic Cell Cycle Nucleus Organization Histone H3-T6 Phosphorylation Organelle Organization Negative Regulation Of Cell Proliferation Mitotic Cell Cycle Process Positive Regulation Of Intracellular Protein Transport Mitotic Cell Cycle Traversing Start Control Point Of Mitotic Cell Cycle CRD-mediated MRNA Stabilization Regulation Of Proteasomal Protein Catabolic Process Regulation Of Nucleocytoplasmic Transport Positive Regulation Of Cell Cycle Process Regulation Of Cell Cycle Peptidyl-serine Autophosphorylation Positive Regulation Of Lipopolysaccharide-mediated Signaling Pathway Cellular Response To Parathyroid Hormone Stimulus Negative Regulation Of Smoothened Signaling Pathway Involved In Dorsal/ventral Neural Tube Patterning Positive Regulation Of Intracellular Transport Regulation Of Cell Division Mitotic Cell Cycle Phase Transition Regulation Of Intracellular Protein Transport Cell Cycle Phase Transition Cell Cycle Process Desmosome Assembly Mitotic Nuclear Envelope Reassembly Negative Regulation Of Glial Cell Apoptotic Process Positive Regulation Of Cell Cycle Regulation Of Tight Junction Assembly DNA Replication Checkpoint Negative Regulation Of Catenin Import Into Nucleus Negative Regulation Of Glucose Import Positive Regulation Of Macrophage Differentiation Nuclear Envelope Reassembly Cell Communication By Electrical Coupling Involved In Cardiac Conduction Calcium-mediated Signaling Using Intracellular Calcium Source Desmosome Organization Response To Parathyroid Hormone Positive Regulation Of Protein Transport Cell Communication By Electrical Coupling	MRNA Processing RNA Splicing MRNA Metabolic Process RNA Processing MRNA Splicing, Via Spliceosome RNA Splicing, Via Transesterification Reactions Nucleobase-containing Compound Metabolic Process RNA Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process Gene Expression Spliceosomal SnRNP Assembly Nitrogen Compound Metabolic Process Regulation Of Viral Process Regulation Of Viral Genome Replication Regulation Of Nitrogen Compound Metabolic Process Negative Regulation Of Biosynthetic Process Positive Regulation Of Viral Process Positive Regulation Of DNA Metabolic Process Regulation Of Gene Expression Ribonucleoprotein Complex Assembly Viral Process Cellular Metabolic Process Regulation Of RNA Metabolic Process Negative Regulation Of Gene Expression Positive Regulation Of Gene Expression Regulation Of Transcription, DNA-templated Cellular Macromolecular Complex Assembly Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Ribonucleoprotein Complex Biogenesis Negative Regulation Of Transcription, DNA-templated Cellular Macromolecule Biosynthetic Process Positive Regulation Of Cellular Metabolic Process Negative Regulation Of Nucleic Acid-templated Transcription Macromolecule Biosynthetic Process Negative Regulation Of RNA Biosynthetic Process Transcription, DNA-templated Regulation Of Metabolic Process Positive Regulation Of Metabolic Process RNA Biosynthetic Process Positive Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Cellular Metabolic Process Transcription Elongation From RNA Polymerase II Promoter Chromosome Organization Positive Regulation Of Response To DNA Damage Stimulus Negative Regulation Of Viral Process Positive Regulation Of Cellular Biosynthetic Process Positive Regulation Of Viral Genome Replication
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