PABPC1 and EIF4G1

Number of citations of the paper that reports this interaction (PMID 9857202)
170

Data Source:
BioGRID (affinity chromatography technology, pull down)
HPRD (in vivo, in vitro)

		PABPC1	EIF4G1
Gene Name		poly(A) binding protein, cytoplasmic 1	eukaryotic translation initiation factor 4 gamma, 1
Image
Gene Ontology Annotations	Cellular Component	Nucleus Cytoplasm Cytosol Focal Adhesion Cytoplasmic Stress Granule Membrane Ribonucleoprotein Complex Cytoplasmic Ribonucleoprotein Granule Extracellular Vesicular Exosome Catalytic Step 2 Spliceosome	Cytosol Membrane Eukaryotic Translation Initiation Factor 4F Complex
	Molecular Function	Nucleotide Binding Protein Binding Protein C-terminus Binding Poly(A) Binding Poly(U) RNA Binding Translation Activator Activity Poly(A) RNA Binding	Translation Initiation Factor Activity Protein Binding Translation Factor Activity, Nucleic Acid Binding Poly(A) RNA Binding
	Biological Process	Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay Nuclear-transcribed MRNA Poly(A) Tail Shortening MRNA Splicing, Via Spliceosome MRNA Polyadenylation Translation Translational Initiation Gene Expression Gene Silencing By RNA Cellular Protein Metabolic Process Positive Regulation Of Translation MRNA Stabilization Positive Regulation Of Nuclear-transcribed MRNA Poly(A) Tail Shortening Positive Regulation Of Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay Negative Regulation Of Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay	Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay Nuclear-transcribed MRNA Poly(A) Tail Shortening Translation Translational Initiation Regulation Of Translational Initiation Insulin Receptor Signaling Pathway Gene Expression Viral Process Cytokine-mediated Signaling Pathway Cellular Protein Metabolic Process
Pathways		Translation initiation complex formation Nonsense-Mediated Decay (NMD) Regulation of mRNA stability by proteins that bind AU-rich elements Deadenylation of mRNA Translation AUF1 (hnRNP D0) destabilizes mRNA L13a-mediated translational silencing of Ceruloplasmin expression Deadenylation-dependent mRNA decay Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) Eukaryotic Translation Initiation Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S Cap-dependent Translation Initiation Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)	Translation initiation complex formation IRS-mediated signalling mTOR signalling S6K1-mediated signalling mTOR signalling mTORC1-mediated signalling AUF1 (hnRNP D0) destabilizes mRNA IGF1R signaling cascade Deadenylation-dependent mRNA decay IRS-related events triggered by IGF1R Eukaryotic Translation Initiation S6K1 signalling Cap-dependent Translation Initiation PKB-mediated events PI3K Cascade Signaling by Insulin receptor Nonsense-Mediated Decay (NMD) Regulation of mRNA stability by proteins that bind AU-rich elements Insulin receptor signalling cascade Deadenylation of mRNA Translation ISG15 antiviral mechanism Interferon Signaling S6K1 signalling Cytokine Signaling in Immune system IRS-related events L13a-mediated translational silencing of Ceruloplasmin expression S6K1-mediated signalling Antiviral mechanism by IFN-stimulated genes mTORC1-mediated signalling Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) Ribosomal scanning and start codon recognition GTP hydrolysis and joining of the 60S ribosomal subunit IRS-mediated signalling Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S PKB-mediated events PI3K Cascade Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)
Drugs
Diseases
GWAS
Protein-Protein Interactions		43 interactors: ANAPC5 APBB1 ATXN2 CARM1 CHAF1A CNOT6 CNOT7 CSDE1 EIF4B EIF4G1 EIF4G3 GNB2L1 GSPT1 GSPT2 HBB HNRNPD HNRNPK IL7R ITCH MAPKAPK2 NDRG1 NFX1 PAIP1 PAIP2 PAIP2B PAN2 PAN3 PCBP1 PCBP2 PCSK7 PIN1 PRMT6 PXN RBM4 SREK1 STAU1 SYCP3 SYNCRIP TERT TOB1 U2AF1 WBP4 YWHAG	24 interactors: ANXA5 CENPU EIF3A EIF3B EIF3I EIF4A1 EIF4A2 EIF4E EIF5 GK HNRNPD HSPB1 HTRA2 MKNK1 MKNK2 NCBP1 NCBP2 PABPC1 PAK2 PDCD4 TRAF2 UBE3A UPF2 ZFYVE9
Entrez ID		26986	1981
HPRD ID		05247	06774
Ensembl ID		ENSG00000070756	ENSG00000114867
Uniprot IDs		E7EQV3 E7ERJ7 P11940	B2RU06 B2RU10 B4DSI9 E7EUU4 E7EX73 E9PGM1 O95065 Q04637 Q96I65
PDB IDs		1CVJ 1G9L 1JGN 1JH4 2K8G 2RQG 2RQH 2X04 3KTP 3KTR 3KUI 3KUJ 3KUR 3KUS 3KUT 3PKN 3PTH 4F02 4F25 4F26	1LJ2 1UG3 2W97 4F02
Enriched GO Terms of Interacting Partners?		MRNA Metabolic Process MRNA Processing Regulation Of Translation Posttranscriptional Regulation Of Gene Expression RNA Processing Nuclear-transcribed MRNA Poly(A) Tail Shortening RNA Catabolic Process Nuclear-transcribed MRNA Catabolic Process MRNA Catabolic Process RNA Metabolic Process MRNA 3'-end Processing Regulation Of Protein Metabolic Process Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay Gene Expression RNA 3'-end Processing Regulation Of Cellular Protein Metabolic Process Cellular Macromolecule Catabolic Process Aromatic Compound Catabolic Process Nucleobase-containing Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Regulation Of Translational Initiation Nitrogen Compound Metabolic Process RNA Splicing Negative Regulation Of Translation Regulation Of Gene Expression MRNA Splicing, Via Spliceosome RNA Splicing, Via Transesterification Reactions Cellular Metabolic Process Regulation Of Metabolic Process RNA Phosphodiester Bond Hydrolysis, Exonucleolytic Catabolic Process Viral Process Posttranscriptional Gene Silencing Regulation Of MRNA Stability Regulation Of RNA Stability Histone H3-R2 Methylation Gene Silencing By RNA Negative Regulation Of Translational Initiation Negative Regulation Of Cellular Metabolic Process Nuclear-transcribed MRNA Catabolic Process, No-go Decay Negative Regulation Of Gene Expression MRNA Stabilization Cellular Macromolecule Biosynthetic Process Negative Regulation Of Protein Metabolic Process Macromolecule Biosynthetic Process Positive Regulation Of Cytoplasmic MRNA Processing Body Assembly Gene Silencing Gene Silencing By MiRNA	Regulation Of Translation Regulation Of Translational Initiation Posttranscriptional Regulation Of Gene Expression Regulation Of Cellular Protein Metabolic Process Regulation Of Protein Metabolic Process RNA Catabolic Process Translational Initiation Nuclear-transcribed MRNA Catabolic Process MRNA Catabolic Process MRNA 3'-end Processing RNA 3'-end Processing Cellular Macromolecule Catabolic Process Aromatic Compound Catabolic Process Nuclear-transcribed MRNA Poly(A) Tail Shortening MRNA Metabolic Process Catabolic Process Viral Process Cellular Macromolecular Complex Assembly Nuclear Export MRNA Processing Regulation Of Gene Expression Translation Nucleocytoplasmic Transport Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay Nuclear Transport Regulation Of Metabolic Process MRNA Export From Nucleus Ribonucleoprotein Complex Assembly Gene Expression RNA Export From Nucleus RNA Processing Formation Of Translation Preinitiation Complex Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay MRNA Transport RNA Transport Cellular Protein Metabolic Process RNA Localization Ribonucleoprotein Complex Biogenesis Regulation Of Cellular Process Gene Silencing By RNA Protein Metabolic Process Cytoplasmic Transport Cellular Metabolic Process Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process MRNA Cis Splicing, Via Spliceosome MRNA Splicing, Via Spliceosome RNA Splicing, Via Transesterification Reactions Positive Regulation Of Extrinsic Apoptotic Signaling Pathway Positive Regulation Of MRNA 3'-end Processing
Tagcloud ?		address adhesion arm comprised coprecipitated cytoplasm cytoplasmic desmoplakin desmosomes destabilized fxr1 g3bp gain mrnas outside particles pkp1 pkp2 pkp3 plakophilins posttranscriptional regulators repeat ribonucleoprotein rnase serve stabilized unaffected upf1	bioinformatics box burkitt cacgtgt carrying cdk4 chip compelling consensus consequently copyright imidazole interesting k562 leukaemia myc myelogenous owing p493 pi polyamide promoters protected pyrrole qpcr rationale recognizes reserved rights
Tagcloud (Difference) ?		address adhesion arm comprised coprecipitated cytoplasm cytoplasmic desmoplakin desmosomes destabilized fxr1 g3bp gain mrnas outside particles pkp1 pkp2 pkp3 plakophilins posttranscriptional regulators repeat ribonucleoprotein rnase serve stabilized unaffected upf1	bioinformatics box burkitt cacgtgt carrying cdk4 chip compelling consensus consequently copyright imidazole interesting k562 leukaemia myc myelogenous owing p493 pi polyamide promoters protected pyrrole qpcr rationale recognizes reserved rights
Tagcloud (Intersection) ?