PABPC1 and PAIP2

Number of citations of the paper that reports this interaction (PMID 11438674)
53

Data Source:
HPRD (in vivo)

		PABPC1	PAIP2
Gene Name		poly(A) binding protein, cytoplasmic 1	poly(A) binding protein interacting protein 2
Image
Gene Ontology Annotations	Cellular Component	Nucleus Cytoplasm Cytosol Focal Adhesion Cytoplasmic Stress Granule Membrane Ribonucleoprotein Complex Cytoplasmic Ribonucleoprotein Granule Extracellular Vesicular Exosome Catalytic Step 2 Spliceosome	Cytoplasm
	Molecular Function	Nucleotide Binding Protein Binding Protein C-terminus Binding Poly(A) Binding Poly(U) RNA Binding Translation Activator Activity Poly(A) RNA Binding	MRNA Binding Protein Binding Translation Repressor Activity
	Biological Process	Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay Nuclear-transcribed MRNA Poly(A) Tail Shortening MRNA Splicing, Via Spliceosome MRNA Polyadenylation Translation Translational Initiation Gene Expression Gene Silencing By RNA Cellular Protein Metabolic Process Positive Regulation Of Translation MRNA Stabilization Positive Regulation Of Nuclear-transcribed MRNA Poly(A) Tail Shortening Positive Regulation Of Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay Negative Regulation Of Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay	Spermatogenesis Memory Negative Regulation Of Translational Initiation Regulation Of Long-term Synaptic Potentiation
Pathways		Translation initiation complex formation Nonsense-Mediated Decay (NMD) Regulation of mRNA stability by proteins that bind AU-rich elements Deadenylation of mRNA Translation AUF1 (hnRNP D0) destabilizes mRNA L13a-mediated translational silencing of Ceruloplasmin expression Deadenylation-dependent mRNA decay Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) Eukaryotic Translation Initiation Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S Cap-dependent Translation Initiation Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)
Drugs
Diseases
GWAS
Protein-Protein Interactions		43 interactors: ANAPC5 APBB1 ATXN2 CARM1 CHAF1A CNOT6 CNOT7 CSDE1 EIF4B EIF4G1 EIF4G3 GNB2L1 GSPT1 GSPT2 HBB HNRNPD HNRNPK IL7R ITCH MAPKAPK2 NDRG1 NFX1 PAIP1 PAIP2 PAIP2B PAN2 PAN3 PCBP1 PCBP2 PCSK7 PIN1 PRMT6 PXN RBM4 SREK1 STAU1 SYCP3 SYNCRIP TERT TOB1 U2AF1 WBP4 YWHAG	5 interactors: APP ELAVL1 PABPC1 RPL11 UBR5
Entrez ID		26986	51247
HPRD ID		05247	05726
Ensembl ID		ENSG00000070756	ENSG00000120727
Uniprot IDs		E7EQV3 E7ERJ7 P11940	Q9BPZ3
PDB IDs		1CVJ 1G9L 1JGN 1JH4 2K8G 2RQG 2RQH 2X04 3KTP 3KTR 3KUI 3KUJ 3KUR 3KUS 3KUT 3PKN 3PTH 4F02 4F25 4F26	1JGN 3KUS 3KUT
Enriched GO Terms of Interacting Partners?		MRNA Metabolic Process MRNA Processing Regulation Of Translation Posttranscriptional Regulation Of Gene Expression RNA Processing Nuclear-transcribed MRNA Poly(A) Tail Shortening RNA Catabolic Process Nuclear-transcribed MRNA Catabolic Process MRNA Catabolic Process RNA Metabolic Process MRNA 3'-end Processing Regulation Of Protein Metabolic Process Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay Gene Expression RNA 3'-end Processing Regulation Of Cellular Protein Metabolic Process Cellular Macromolecule Catabolic Process Aromatic Compound Catabolic Process Nucleobase-containing Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Regulation Of Translational Initiation Nitrogen Compound Metabolic Process RNA Splicing Negative Regulation Of Translation Regulation Of Gene Expression MRNA Splicing, Via Spliceosome RNA Splicing, Via Transesterification Reactions Cellular Metabolic Process Regulation Of Metabolic Process RNA Phosphodiester Bond Hydrolysis, Exonucleolytic Catabolic Process Viral Process Posttranscriptional Gene Silencing Regulation Of MRNA Stability Regulation Of RNA Stability Histone H3-R2 Methylation Gene Silencing By RNA Negative Regulation Of Translational Initiation Negative Regulation Of Cellular Metabolic Process Nuclear-transcribed MRNA Catabolic Process, No-go Decay Negative Regulation Of Gene Expression MRNA Stabilization Cellular Macromolecule Biosynthetic Process Negative Regulation Of Protein Metabolic Process Macromolecule Biosynthetic Process Positive Regulation Of Cytoplasmic MRNA Processing Body Assembly Gene Silencing Gene Silencing By MiRNA	MRNA Stabilization MRNA Polyadenylation Regulation Of Translation RNA Polyadenylation Regulation Of MRNA Stability Regulation Of RNA Stability Posttranscriptional Regulation Of Gene Expression Positive Regulation Of Translation MRNA Metabolic Process MRNA 3'-end Processing Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay RNA 3'-end Processing Regulation Of Cellular Protein Metabolic Process Regulation Of Protein Metabolic Process Nuclear-transcribed MRNA Catabolic Process Synaptic Growth At Neuromuscular Junction MRNA Catabolic Process Cellular Macromolecule Catabolic Process RNA Catabolic Process Collateral Sprouting In Absence Of Injury Negative Regulation Of Histone H2A K63-linked Ubiquitination Intracellular Receptor Signaling Pathway Regulation Of Histone Ubiquitination Negative Regulation Of Protein K63-linked Ubiquitination Negative Regulation Of Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay Translational Initiation Positive Regulation Of Cellular Protein Metabolic Process Collateral Sprouting Axon Midline Choice Point Recognition Smooth Endoplasmic Reticulum Calcium Ion Homeostasis Regulation Of Protein K63-linked Ubiquitination Progesterone Receptor Signaling Pathway Positive Regulation Of Protein Metabolic Process Axon Choice Point Recognition Negative Regulation Of Double-strand Break Repair Negative Regulation Of DNA Repair Neuron Remodeling Gene Expression 3'-UTR-mediated MRNA Stabilization Positive Regulation Of Catenin Import Into Nucleus Positive Regulation Of Nuclear-transcribed MRNA Poly(A) Tail Shortening Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Gene Expression Positive Regulation Of Protein Import Into Nucleus, Translocation Positive Regulation Of Cellular Biosynthetic Process MRNA Processing Positive Regulation Of MRNA 3'-end Processing Positive Regulation Of Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay Aromatic Compound Catabolic Process Regulation Of MRNA 3'-end Processing
Tagcloud ?		address adhesion arm comprised coprecipitated cytoplasm cytoplasmic desmoplakin desmosomes destabilized fxr1 g3bp gain mrnas outside particles pkp1 pkp2 pkp3 plakophilins posttranscriptional regulators repeat ribonucleoprotein rnase serve stabilized unaffected upf1	5l avian bicistronic bona closed compatible concomitantly explanation fide herpesvirus ie immediate ires leader manners marek mdv1 message micrornas mutagenesis neurovirulence pabp1 poly pool pp14 recruitment ribosome serotype virally
Tagcloud (Difference) ?		address adhesion arm comprised coprecipitated cytoplasm cytoplasmic desmoplakin desmosomes destabilized fxr1 g3bp gain mrnas outside particles pkp1 pkp2 pkp3 plakophilins posttranscriptional regulators repeat ribonucleoprotein rnase serve stabilized unaffected upf1	5l avian bicistronic bona closed compatible concomitantly explanation fide herpesvirus ie immediate ires leader manners marek mdv1 message micrornas mutagenesis neurovirulence pabp1 poly pool pp14 recruitment ribosome serotype virally
Tagcloud (Intersection) ?