PABPC1 and CNOT6

Number of citations of the paper that reports this interaction (PMID 17785442)
43

Data Source:
BioGRID (pull down)

		PABPC1	CNOT6
Gene Name		poly(A) binding protein, cytoplasmic 1	CCR4-NOT transcription complex, subunit 6
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Cytoplasm Cytosol Focal Adhesion Cytoplasmic Stress Granule Membrane Ribonucleoprotein Complex Cytoplasmic Ribonucleoprotein Granule Extracellular Vesicular Exosome Catalytic Step 2 Spliceosome	Nucleus Cytosol Membrane CCR4-NOT Complex
	Molecular Function	Nucleotide Binding Protein Binding Protein C-terminus Binding Poly(A) Binding Poly(U) RNA Binding Translation Activator Activity Poly(A) RNA Binding	RNA Binding Exoribonuclease Activity Poly(A)-specific Ribonuclease Activity Protein Binding Metal Ion Binding
	Biological Process	Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay Nuclear-transcribed MRNA Poly(A) Tail Shortening MRNA Splicing, Via Spliceosome MRNA Polyadenylation Translation Translational Initiation Gene Expression Gene Silencing By RNA Cellular Protein Metabolic Process Positive Regulation Of Translation MRNA Stabilization Positive Regulation Of Nuclear-transcribed MRNA Poly(A) Tail Shortening Positive Regulation Of Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay Negative Regulation Of Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay	Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay Nuclear-transcribed MRNA Poly(A) Tail Shortening Transcription, DNA-templated Regulation Of Transcription, DNA-templated Regulation Of Translation Positive Regulation Of Cell Proliferation Gene Expression Positive Regulation Of Cytoplasmic MRNA Processing Body Assembly Gene Silencing By MiRNA Exonucleolytic Nuclear-transcribed MRNA Catabolic Process Involved In Deadenylation-dependent Decay Nuclear-transcribed MRNA Catabolic Process, No-go Decay RNA Phosphodiester Bond Hydrolysis, Exonucleolytic Positive Regulation Of Ligand-dependent Nuclear Receptor Transcription Coactivator Activity
Pathways		Translation initiation complex formation Nonsense-Mediated Decay (NMD) Regulation of mRNA stability by proteins that bind AU-rich elements Deadenylation of mRNA Translation AUF1 (hnRNP D0) destabilizes mRNA L13a-mediated translational silencing of Ceruloplasmin expression Deadenylation-dependent mRNA decay Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) Eukaryotic Translation Initiation Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S Cap-dependent Translation Initiation Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)	Deadenylation of mRNA Deadenylation-dependent mRNA decay
Drugs
Diseases
GWAS
Protein-Protein Interactions		43 interactors: ANAPC5 APBB1 ATXN2 CARM1 CHAF1A CNOT6 CNOT7 CSDE1 EIF4B EIF4G1 EIF4G3 GNB2L1 GSPT1 GSPT2 HBB HNRNPD HNRNPK IL7R ITCH MAPKAPK2 NDRG1 NFX1 PAIP1 PAIP2 PAIP2B PAN2 PAN3 PCBP1 PCBP2 PCSK7 PIN1 PRMT6 PXN RBM4 SREK1 STAU1 SYCP3 SYNCRIP TERT TOB1 U2AF1 WBP4 YWHAG	3 interactors: CNOT7 CNOT8 PABPC1
Entrez ID		26986	57472
HPRD ID		05247	12341
Ensembl ID		ENSG00000070756	ENSG00000113300
Uniprot IDs		E7EQV3 E7ERJ7 P11940	Q9ULM6
PDB IDs		1CVJ 1G9L 1JGN 1JH4 2K8G 2RQG 2RQH 2X04 3KTP 3KTR 3KUI 3KUJ 3KUR 3KUS 3KUT 3PKN 3PTH 4F02 4F25 4F26
Enriched GO Terms of Interacting Partners?		MRNA Metabolic Process MRNA Processing Regulation Of Translation Posttranscriptional Regulation Of Gene Expression RNA Processing Nuclear-transcribed MRNA Poly(A) Tail Shortening RNA Catabolic Process Nuclear-transcribed MRNA Catabolic Process MRNA Catabolic Process RNA Metabolic Process MRNA 3'-end Processing Regulation Of Protein Metabolic Process Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay Gene Expression RNA 3'-end Processing Regulation Of Cellular Protein Metabolic Process Cellular Macromolecule Catabolic Process Aromatic Compound Catabolic Process Nucleobase-containing Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Regulation Of Translational Initiation Nitrogen Compound Metabolic Process RNA Splicing Negative Regulation Of Translation Regulation Of Gene Expression MRNA Splicing, Via Spliceosome RNA Splicing, Via Transesterification Reactions Cellular Metabolic Process Regulation Of Metabolic Process RNA Phosphodiester Bond Hydrolysis, Exonucleolytic Catabolic Process Viral Process Posttranscriptional Gene Silencing Regulation Of MRNA Stability Regulation Of RNA Stability Histone H3-R2 Methylation Gene Silencing By RNA Negative Regulation Of Translational Initiation Negative Regulation Of Cellular Metabolic Process Nuclear-transcribed MRNA Catabolic Process, No-go Decay Negative Regulation Of Gene Expression MRNA Stabilization Cellular Macromolecule Biosynthetic Process Negative Regulation Of Protein Metabolic Process Macromolecule Biosynthetic Process Positive Regulation Of Cytoplasmic MRNA Processing Body Assembly Gene Silencing Gene Silencing By MiRNA	Positive Regulation Of MRNA Catabolic Process Nuclear-transcribed MRNA Poly(A) Tail Shortening Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay Gene Silencing By RNA MRNA 3'-end Processing Gene Silencing RNA 3'-end Processing Nuclear-transcribed MRNA Catabolic Process MRNA Catabolic Process RNA Catabolic Process Positive Regulation Of Nuclear-transcribed MRNA Poly(A) Tail Shortening Positive Regulation Of MRNA 3'-end Processing Positive Regulation Of Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay Regulation Of MRNA 3'-end Processing Regulation Of Translation Exonucleolytic Nuclear-transcribed MRNA Catabolic Process Involved In Deadenylation-dependent Decay Nuclear-transcribed MRNA Catabolic Process, Exonucleolytic RNA Phosphodiester Bond Hydrolysis, Exonucleolytic MRNA Processing Gene Silencing By MiRNA Aromatic Compound Catabolic Process Posttranscriptional Regulation Of Gene Expression Posttranscriptional Gene Silencing MRNA Metabolic Process RNA Processing Regulation Of MRNA Processing Cellular Macromolecule Catabolic Process RNA Phosphodiester Bond Hydrolysis Negative Regulation Of Gene Expression Regulation Of Gene Expression, Epigenetic Catabolic Process Negative Regulation Of Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay Nucleic Acid Phosphodiester Bond Hydrolysis Regulation Of Cellular Protein Metabolic Process Deadenylation-dependent Decapping Of Nuclear-transcribed MRNA Regulation Of Protein Metabolic Process Cytoplasmic MRNA Processing Body Assembly Positive Regulation Of Cellular Metabolic Process Negative Regulation Of Cell Proliferation RNA Metabolic Process Positive Regulation Of Metabolic Process Gene Expression MRNA Stabilization Positive Regulation Of Cell Proliferation Cellular Macromolecule Biosynthetic Process MRNA Polyadenylation Macromolecule Biosynthetic Process RNA Polyadenylation Regulation Of MRNA Stability Regulation Of RNA Metabolic Process
Tagcloud ?		address adhesion arm comprised coprecipitated cytoplasm cytoplasmic desmoplakin desmosomes destabilized fxr1 g3bp gain mrnas outside particles pkp1 pkp2 pkp3 plakophilins posttranscriptional regulators repeat ribonucleoprotein rnase serve stabilized unaffected upf1	adam33 allergen allergens allergic black boston cockroach dataset dust fcer1a genotypic haplotype haplotypes house il5ra jak3 maml1 marginally mite nod1 rs11739089 rs12136904t rs6665683 rs6665683t rs7851969 sensitization sensitizations snps strongest
Tagcloud (Difference) ?		address adhesion arm comprised coprecipitated cytoplasm cytoplasmic desmoplakin desmosomes destabilized fxr1 g3bp gain mrnas outside particles pkp1 pkp2 pkp3 plakophilins posttranscriptional regulators repeat ribonucleoprotein rnase serve stabilized unaffected upf1	adam33 allergen allergens allergic black boston cockroach dataset dust fcer1a genotypic haplotype haplotypes house il5ra jak3 maml1 marginally mite nod1 rs11739089 rs12136904t rs6665683 rs6665683t rs7851969 sensitization sensitizations snps strongest
Tagcloud (Intersection) ?