PABPC1 and EIF4G3

Number of citations of the paper that reports this interaction (PMID 9857202)
170

Data Source:
BioGRID (affinity chromatography technology, affinity chromatography technology)
HPRD (in vivo, in vitro)

		PABPC1	EIF4G3
Gene Name		poly(A) binding protein, cytoplasmic 1	eukaryotic translation initiation factor 4 gamma, 3
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Gene Ontology Annotations	Cellular Component	Nucleus Cytoplasm Cytosol Focal Adhesion Cytoplasmic Stress Granule Membrane Ribonucleoprotein Complex Cytoplasmic Ribonucleoprotein Granule Extracellular Vesicular Exosome Catalytic Step 2 Spliceosome	Cytosol Eukaryotic Translation Initiation Factor 4F Complex
	Molecular Function	Nucleotide Binding Protein Binding Protein C-terminus Binding Poly(A) Binding Poly(U) RNA Binding Translation Activator Activity Poly(A) RNA Binding	RNA Cap Binding Translation Initiation Factor Activity Translation Factor Activity, Nucleic Acid Binding Poly(A) RNA Binding
	Biological Process	Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay Nuclear-transcribed MRNA Poly(A) Tail Shortening MRNA Splicing, Via Spliceosome MRNA Polyadenylation Translation Translational Initiation Gene Expression Gene Silencing By RNA Cellular Protein Metabolic Process Positive Regulation Of Translation MRNA Stabilization Positive Regulation Of Nuclear-transcribed MRNA Poly(A) Tail Shortening Positive Regulation Of Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay Negative Regulation Of Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay	Translational Initiation Regulation Of Translational Initiation Viral Process Cytokine-mediated Signaling Pathway
Pathways		Translation initiation complex formation Nonsense-Mediated Decay (NMD) Regulation of mRNA stability by proteins that bind AU-rich elements Deadenylation of mRNA Translation AUF1 (hnRNP D0) destabilizes mRNA L13a-mediated translational silencing of Ceruloplasmin expression Deadenylation-dependent mRNA decay Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) Eukaryotic Translation Initiation Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S Cap-dependent Translation Initiation Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)	ISG15 antiviral mechanism Interferon Signaling Cytokine Signaling in Immune system Antiviral mechanism by IFN-stimulated genes
Drugs
Diseases
GWAS
Protein-Protein Interactions		43 interactors: ANAPC5 APBB1 ATXN2 CARM1 CHAF1A CNOT6 CNOT7 CSDE1 EIF4B EIF4G1 EIF4G3 GNB2L1 GSPT1 GSPT2 HBB HNRNPD HNRNPK IL7R ITCH MAPKAPK2 NDRG1 NFX1 PAIP1 PAIP2 PAIP2B PAN2 PAN3 PCBP1 PCBP2 PCSK7 PIN1 PRMT6 PXN RBM4 SREK1 STAU1 SYCP3 SYNCRIP TERT TOB1 U2AF1 WBP4 YWHAG	7 interactors: CAMK1 EIF4A1 EIF4E LIG4 MKNK1 PABPC1 VAV2
Entrez ID		26986	8672
HPRD ID		05247	06802
Ensembl ID		ENSG00000070756	ENSG00000075151
Uniprot IDs		E7EQV3 E7ERJ7 P11940	O43432 Q504Z1 Q59GJ0
PDB IDs		1CVJ 1G9L 1JGN 1JH4 2K8G 2RQG 2RQH 2X04 3KTP 3KTR 3KUI 3KUJ 3KUR 3KUS 3KUT 3PKN 3PTH 4F02 4F25 4F26	1HU3
Enriched GO Terms of Interacting Partners?		MRNA Metabolic Process MRNA Processing Regulation Of Translation Posttranscriptional Regulation Of Gene Expression RNA Processing Nuclear-transcribed MRNA Poly(A) Tail Shortening RNA Catabolic Process Nuclear-transcribed MRNA Catabolic Process MRNA Catabolic Process RNA Metabolic Process MRNA 3'-end Processing Regulation Of Protein Metabolic Process Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay Gene Expression RNA 3'-end Processing Regulation Of Cellular Protein Metabolic Process Cellular Macromolecule Catabolic Process Aromatic Compound Catabolic Process Nucleobase-containing Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Regulation Of Translational Initiation Nitrogen Compound Metabolic Process RNA Splicing Negative Regulation Of Translation Regulation Of Gene Expression MRNA Splicing, Via Spliceosome RNA Splicing, Via Transesterification Reactions Cellular Metabolic Process Regulation Of Metabolic Process RNA Phosphodiester Bond Hydrolysis, Exonucleolytic Catabolic Process Viral Process Posttranscriptional Gene Silencing Regulation Of MRNA Stability Regulation Of RNA Stability Histone H3-R2 Methylation Gene Silencing By RNA Negative Regulation Of Translational Initiation Negative Regulation Of Cellular Metabolic Process Nuclear-transcribed MRNA Catabolic Process, No-go Decay Negative Regulation Of Gene Expression MRNA Stabilization Cellular Macromolecule Biosynthetic Process Negative Regulation Of Protein Metabolic Process Macromolecule Biosynthetic Process Positive Regulation Of Cytoplasmic MRNA Processing Body Assembly Gene Silencing Gene Silencing By MiRNA	Nuclear-transcribed MRNA Poly(A) Tail Shortening Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay MRNA 3'-end Processing RNA 3'-end Processing Nuclear-transcribed MRNA Catabolic Process MRNA Catabolic Process RNA Catabolic Process Translational Initiation Regulation Of Translation MRNA Processing Aromatic Compound Catabolic Process Posttranscriptional Regulation Of Gene Expression DNA Ligation Involved In DNA Recombination MRNA Metabolic Process Viral Process RNA Processing Translation Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Cellular Response To Organic Substance Negative Regulation Of Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Synapse Structural Plasticity Cellular Macromolecule Catabolic Process Lagging Strand Elongation Pro-B Cell Differentiation Enzyme Linked Receptor Protein Signaling Pathway Regulation Of Protein Metabolic Process Apoptotic Process Establishment Of Integrated Proviral Latency Programmed Cell Death Cellular Response To Stimulus Nucleocytoplasmic Transport System Development Nuclear Transport Cell Death Death Immunoglobulin V(D)J Recombination Establishment Of Viral Latency T Cell Receptor V(D)J Recombination DNA Ligation Involved In DNA Repair Cellular Protein Metabolic Process Positive Regulation Of Nuclear-transcribed MRNA Poly(A) Tail Shortening Regulation Of Synapse Structural Plasticity Response To Organic Substance Lymphoid Progenitor Cell Differentiation Positive Regulation Of Protein Export From Nucleus DNA Ligation Apoptotic Signaling Pathway Positive Regulation Of MRNA 3'-end Processing Positive Regulation Of Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay
Tagcloud ?		address adhesion arm comprised coprecipitated cytoplasm cytoplasmic desmoplakin desmosomes destabilized fxr1 g3bp gain mrnas outside particles pkp1 pkp2 pkp3 plakophilins posttranscriptional regulators repeat ribonucleoprotein rnase serve stabilized unaffected upf1	absent aminopeptidase anpep antigen autoregulatory controlling deaf1 deformed degrades diminished encodes fine histocompatibility ko lnscs lymph maintaining mhc nodes peripheral polysome profiling protease pta stromal t1d translation tuning
Tagcloud (Difference) ?		address adhesion arm comprised coprecipitated cytoplasm cytoplasmic desmoplakin desmosomes destabilized fxr1 g3bp gain mrnas outside particles pkp1 pkp2 pkp3 plakophilins posttranscriptional regulators repeat ribonucleoprotein rnase serve stabilized unaffected upf1	absent aminopeptidase anpep antigen autoregulatory controlling deaf1 deformed degrades diminished encodes fine histocompatibility ko lnscs lymph maintaining mhc nodes peripheral polysome profiling protease pta stromal t1d translation tuning
Tagcloud (Intersection) ?