SEC22A and STX4

Number of citations of the paper that reports this interaction (PubMedID 25416956)
56

Data Source:
BioGRID (two hybrid, two hybrid)

		SEC22A	STX4
Description		SEC22 homolog A, vesicle trafficking protein	syntaxin 4
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Cytoplasm Endoplasmic Reticulum Endoplasmic Reticulum Membrane Membrane	Storage Vacuole Extracellular Space Cytoplasm Endosome Vacuole Trans-Golgi Network Cytosol Plasma Membrane Cell Surface Endomembrane System Membrane Basolateral Plasma Membrane Lamellipodium Phagocytic Vesicle Membrane SNARE Complex Stereocilium Neuron Projection Membrane Myelin Sheath Adaxonal Region Somatodendritic Compartment Specific Granule Cell Projection Neuron Projection Dendritic Spine Lateral Loop Synapse Phagocytic Vesicle Perinuclear Region Of Cytoplasm Extracellular Exosome Schaffer Collateral - CA1 Synapse Postsynapse Glutamatergic Synapse
	Molecular Function	SNAP Receptor Activity Protein Binding	SNARE Binding SNAP Receptor Activity Protein Binding Sphingomyelin Phosphodiesterase Activator Activity
	Biological Process	Endoplasmic Reticulum To Golgi Vesicle-mediated Transport Protein Transport Vesicle-mediated Transport Membrane Fusion	Positive Regulation Of Immunoglobulin Production Neurotransmitter Transport Intracellular Protein Transport Exocytosis Vesicle Fusion Sensory Perception Of Sound Positive Regulation Of Cell Population Proliferation Vesicle-mediated Transport Regulation Of Exocytosis Positive Regulation Of Cell Migration Protein Localization To Cell Surface Cellular Response To Oxidative Stress SNARE Complex Assembly Positive Regulation Of Insulin Secretion Involved In Cellular Response To Glucose Stimulus Positive Regulation Of Catalytic Activity Positive Regulation Of Eosinophil Degranulation Positive Regulation Of Cell Adhesion Vesicle Docking Organelle Fusion Positive Regulation Of Chemotaxis Long-term Synaptic Potentiation Membrane Organization Cellular Response To Type II Interferon Regulation Of Postsynaptic Membrane Neurotransmitter Receptor Levels Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Positive Regulation Of Protein Localization To Plasma Membrane Cornified Envelope Assembly Positive Regulation Of Protein Localization To Cell Surface
Pathways		COPII-mediated vesicle transport	Disinhibition of SNARE formation ER-Phagosome pathway Translocation of SLC2A4 (GLUT4) to the plasma membrane trans-Golgi Network Vesicle Budding Other interleukin signaling
Drugs
Diseases
GWAS		Gestational age at birth (maternal effect) ( 28877031)	Response to metformin (IC50) ( 28173075) Triglyceride levels ( 32203549)
Interacting Genes		108 interacting genes: ADGRG3 AQP6 ASGR2 ATP6AP2 BIK BNIP3 C10orf67 C16orf54 C16orf92 CALN1 CD207 CD300A CD7 CD74 CISD2 CLEC10A CLEC12B CLEC2D CLEC7A CREB3L1 CYB561 CYBRD1 DDIT4L DIABLO DTX2 EDA ELOVL4 ERLIN1 ERVFRD-1 FAM174A FAM209A FATE1 FUT3 GAD2 GGT6 GJB5 GJB6 GPR37L1 GRAMD2B HAVCR2 HCST HSD17B11 ICAM3 KCNJ2 LDAF1 LDLRAD1 LHFPL5 LMNA LPAR6 LRRC25 LSMEM2 MCOLN1 MFF MGST2 MINAR1 MS4A14 MS4A3 MS4A4A MSR1 OPRM1 PACC1 PEX12 PHB1 PTGES RASGRP4 RETREG3 RILPL1 RNASEK RNF144A RNF19B RNF5 SAR1A SCN3B SDHAF2 SFTPC SLC10A1 SLC14A2 SLC18A1 SLC30A2 SLC35H1 SLC39A2 SMIM3 SPAG4 STMN4 STOML3 STX1A STX2 STX4 SUSD3 SYNE4 TFR2 TLCD4 TMED9 TMEM106C TMEM174 TMEM237 TMEM45B TMEM52B TMEM71 TMEM79 TMIE TMPRSS2 TNFSF14 TP53INP1 TRAT1 TRIM59 TYRP1 ZFYVE27	65 interacting genes: ABI2 ACTB ANKRD46 BET1 CYBRD1 DLG1 DNAJC5 FAXDC2 GIMAP5 GOSR2 GPR152 ITSN2 LLGL1 LMNA NAPA NAPB NSF PLP1 PSMA3 RAB11A RAB4A RAB5A RNF4 SCRIB SEC22A SEC22B SEPTIN5 SERP1 SGPL1 SH3GLB2 SNAP23 SNAP25 SNAP47 STX10 STX11 STX16 STX1A STX1B STX2 STX3 STX5 STXBP3 STXBP4 STXBP5 STXBP6 SYT1 SYT4 SYT7 TCEANC TMEM203 TRAF3IP3 TXLNA TXLNB TXLNG USE1 VAMP1 VAMP2 VAMP3 VAMP4 VAMP7 VAMP8 VAPB VMA12 VTI1B ZFPL1
Entrez ID		26984	6810
HPRD ID		15313	01722
Ensembl ID		ENSG00000121542	ENSG00000103496
Uniprot IDs		Q96IW7	B7Z425 Q12846
PDB IDs
Enriched GO Terms of Interacting Partners?		Membrane Protein Binding Plasma Membrane Endoplasmic Reticulum Membrane Endoplasmic Reticulum Lysosomal Membrane PH-gated Chloride Channel Activity Transmembrane Transport Pattern Recognition Receptor Activity Ascorbate Homeostasis Icosanoid Biosynthetic Process Endoplasmic Reticulum-autophagosome Adaptor Activity Transmembrane Monodehydroascorbate Reductase Activity D-mannose Binding	SNAP Receptor Activity SNARE Complex Membrane Fusion Syntaxin Binding Vesicle Fusion Organelle Membrane Fusion Organelle Fusion Vesicle-mediated Transport Membrane Organization SNARE Binding Vesicle Organization Exocytosis Organelle Localization By Membrane Tethering Establishment Of Localization In Cell Membrane Docking Secretion By Cell Vesicle Docking Protein Transport Secretion Establishment Of Protein Localization Vesicle-mediated Transport In Synapse Golgi Vesicle Transport Cellular Localization Intracellular Protein Localization Intracellular Transport Organelle Localization Regulation Of Vesicle-mediated Transport Endomembrane System Calcium-ion Regulated Exocytosis SNARE Complex Assembly Membrane Regulated Exocytosis Regulation Of Exocytosis Syntaxin-1 Binding Synaptic Vesicle Exocytosis Synaptic Vesicle Fusion To Presynaptic Active Zone Membrane Intracellular Protein Transport Vesicle Fusion To Plasma Membrane Regulation Of Secretion By Cell Synaptic Vesicle Membrane Regulation Of Secretion Synaptic Vesicle Membrane Organization Signal Release Regulation Of Transport Regulation Of Regulated Secretory Pathway Synaptic Vesicle Calcium Ion-regulated Exocytosis Of Neurotransmitter Vesicle Docking Involved In Exocytosis Synaptobrevin 2-SNAP-25-syntaxin-1a Complex Post-Golgi Vesicle-mediated Transport
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