STX4 and ANKRD46

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		STX4	ANKRD46
Description		syntaxin 4	ankyrin repeat domain 46
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Storage Vacuole Extracellular Space Cytoplasm Endosome Vacuole Trans-Golgi Network Cytosol Plasma Membrane Cell Surface Endomembrane System Membrane Basolateral Plasma Membrane Lamellipodium Phagocytic Vesicle Membrane SNARE Complex Stereocilium Neuron Projection Membrane Myelin Sheath Adaxonal Region Somatodendritic Compartment Specific Granule Cell Projection Neuron Projection Dendritic Spine Lateral Loop Synapse Phagocytic Vesicle Perinuclear Region Of Cytoplasm Extracellular Exosome Schaffer Collateral - CA1 Synapse Postsynapse Glutamatergic Synapse	Membrane
	Molecular Function	SNARE Binding SNAP Receptor Activity Protein Binding Sphingomyelin Phosphodiesterase Activator Activity	Protein Binding
	Biological Process	Positive Regulation Of Immunoglobulin Production Neurotransmitter Transport Intracellular Protein Transport Exocytosis Vesicle Fusion Sensory Perception Of Sound Positive Regulation Of Cell Population Proliferation Vesicle-mediated Transport Regulation Of Exocytosis Positive Regulation Of Cell Migration Protein Localization To Cell Surface Cellular Response To Oxidative Stress SNARE Complex Assembly Positive Regulation Of Insulin Secretion Involved In Cellular Response To Glucose Stimulus Positive Regulation Of Catalytic Activity Positive Regulation Of Eosinophil Degranulation Positive Regulation Of Cell Adhesion Vesicle Docking Organelle Fusion Positive Regulation Of Chemotaxis Long-term Synaptic Potentiation Membrane Organization Cellular Response To Type II Interferon Regulation Of Postsynaptic Membrane Neurotransmitter Receptor Levels Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Positive Regulation Of Protein Localization To Plasma Membrane Cornified Envelope Assembly Positive Regulation Of Protein Localization To Cell Surface
Pathways		Disinhibition of SNARE formation ER-Phagosome pathway Translocation of SLC2A4 (GLUT4) to the plasma membrane trans-Golgi Network Vesicle Budding Other interleukin signaling
Drugs
Diseases
GWAS		Response to metformin (IC50) ( 28173075) Triglyceride levels ( 32203549)	Atrioventricular conduction ( 21041692) Body mass index ( 26426971) Percentage gas trapping ( 26030696)
Interacting Genes		65 interacting genes: ABI2 ACTB ANKRD46 BET1 CYBRD1 DLG1 DNAJC5 FAXDC2 GIMAP5 GOSR2 GPR152 ITSN2 LLGL1 LMNA NAPA NAPB NSF PLP1 PSMA3 RAB11A RAB4A RAB5A RNF4 SCRIB SEC22A SEC22B SEPTIN5 SERP1 SGPL1 SH3GLB2 SNAP23 SNAP25 SNAP47 STX10 STX11 STX16 STX1A STX1B STX2 STX3 STX5 STXBP3 STXBP4 STXBP5 STXBP6 SYT1 SYT4 SYT7 TCEANC TMEM203 TRAF3IP3 TXLNA TXLNB TXLNG USE1 VAMP1 VAMP2 VAMP3 VAMP4 VAMP7 VAMP8 VAPB VMA12 VTI1B ZFPL1	63 interacting genes: AMIGO1 APH1A AQP6 ARL13B BIK BSCL2 C16orf54 CD22 CD46 CLDN20 CLDN7 CLEC4D CRB3 CREB3L1 CXADR CYB561 EBP EFNB1 EFNB2 ELOVL4 FAM174A FAM209A FFAR2 GOLM1 GPR152 GPR42 GPX8 HSD17B11 HSD17B13 IFNLR1 KASH5 KIR2DL3 LAMTOR5 LDLRAD1 LRRC25 MFF MMGT1 MUC1 NCAPH2 NSG2 PLPP4 PVR RELL2 RETREG3 SCN3B SECTM1 SHISA3 SLC10A6 SLC16A2 SLC18A1 SLC39A9 ST6GALNAC6 STX1A STX2 STX4 SUSD3 THAP4 TIMMDC1 TMEM248 TMEM31 TMEM45B TMEM79 TMPRSS2
Entrez ID		6810	157567
HPRD ID		01722	14103
Ensembl ID		ENSG00000103496	ENSG00000186106
Uniprot IDs		B7Z425 Q12846	B3KT99 Q86W74
PDB IDs
Enriched GO Terms of Interacting Partners?		SNAP Receptor Activity SNARE Complex Membrane Fusion Syntaxin Binding Vesicle Fusion Organelle Membrane Fusion Organelle Fusion Vesicle-mediated Transport Membrane Organization SNARE Binding Vesicle Organization Exocytosis Organelle Localization By Membrane Tethering Establishment Of Localization In Cell Membrane Docking Secretion By Cell Vesicle Docking Protein Transport Secretion Establishment Of Protein Localization Vesicle-mediated Transport In Synapse Golgi Vesicle Transport Cellular Localization Intracellular Protein Localization Intracellular Transport Organelle Localization Regulation Of Vesicle-mediated Transport Endomembrane System Calcium-ion Regulated Exocytosis SNARE Complex Assembly Membrane Regulated Exocytosis Regulation Of Exocytosis Syntaxin-1 Binding Synaptic Vesicle Exocytosis Synaptic Vesicle Fusion To Presynaptic Active Zone Membrane Intracellular Protein Transport Vesicle Fusion To Plasma Membrane Regulation Of Secretion By Cell Synaptic Vesicle Membrane Regulation Of Secretion Synaptic Vesicle Membrane Organization Signal Release Regulation Of Transport Regulation Of Regulated Secretory Pathway Synaptic Vesicle Calcium Ion-regulated Exocytosis Of Neurotransmitter Vesicle Docking Involved In Exocytosis Synaptobrevin 2-SNAP-25-syntaxin-1a Complex Post-Golgi Vesicle-mediated Transport	Membrane Protein Binding Plasma Membrane Steroid Dehydrogenase Activity
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