STX4 and STXBP5

Number of citations of the paper that reports this interaction (PMID 12832401)
26

Data Source:
HPRD (in vitro)

		STX4	STXBP5
Gene Name		syntaxin 4	syntaxin binding protein 5 (tomosyn)
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Extracellular Space Intracellular Endosome Vacuole Trans-Golgi Network Cytosol Plasma Membrane Synaptic Vesicle Cell Surface Membrane Integral Component Of Membrane Basolateral Plasma Membrane Lamellipodium SNARE Complex Myelin Sheath Adaxonal Region Somatodendritic Compartment Specific Granule Dendritic Spine Lateral Loop Synapse Perinuclear Region Of Cytoplasm Extracellular Vesicular Exosome	Cytoplasm Acetylcholine-gated Channel Complex Synaptic Vesicle Cell Junction Cytoplasmic Vesicle Membrane
	Molecular Function	SNARE Binding SNAP Receptor Activity Protein Binding Sphingomyelin Phosphodiesterase Activator Activity	Syntaxin-1 Binding
	Biological Process	Intracellular Protein Transport Post-Golgi Vesicle-mediated Transport Blood Coagulation Positive Regulation Of Cell Proliferation Regulation Of Exocytosis Platelet Activation Positive Regulation Of Cell Migration Synaptic Vesicle Fusion To Presynaptic Membrane Response To Hydroperoxide SNARE Complex Assembly Positive Regulation Of Insulin Secretion Involved In Cellular Response To Glucose Stimulus Positive Regulation Of Catalytic Activity Positive Regulation Of Eosinophil Degranulation Positive Regulation Of Cell Adhesion Vesicle Docking Organelle Fusion Positive Regulation Of Chemotaxis Positive Regulation Of Immunoglobulin Secretion Long-term Synaptic Potentiation Membrane Organization Positive Regulation Of Establishment Of Protein Localization To Plasma Membrane Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Positive Regulation Of Protein Localization To Plasma Membrane Positive Regulation Of Protein Localization To Cell Surface	Exocytosis Regulation Of Gene Expression Protein Transport Regulation Of Exocytosis Regulation Of Blood Coagulation Positive Regulation Of Exocytosis
Pathways		Response to elevated platelet cytosolic Ca2+ Translocation of GLUT4 to the plasma membrane Disinhibition of SNARE formation Platelet activation, signaling and aggregation trans-Golgi Network Vesicle Budding Clathrin derived vesicle budding
Drugs
Diseases
GWAS			Coagulation factor levels ( 20231535)
Protein-Protein Interactions		48 interactors: ACTB BET1 CYBRD1 DLG1 GIMAP5 GOSR2 ITSN2 LLGL1 NAPA NAPB NSF PSMA3 RAB11A RAB4A RAB5A SCRIB SEC22A SEPT5 SNAP23 SNAP25 SNAP29 SNAP47 STX12 STX16 STX3 STX5 STX6 STX7 STX8 STXBP3 STXBP4 STXBP5 STXBP6 SYT1 SYT4 SYT7 TXLNA TXLNB TXLNG VAMP1 VAMP2 VAMP3 VAMP4 VAMP5 VAMP7 VAMP8 VAPB VTI1B	3 interactors: SNAP23 STX1A STX4
Entrez ID		6810	134957
HPRD ID		01722	06845
Ensembl ID		ENSG00000103496
Uniprot IDs		A8MXY0 B7Z425 Q12846	Q5T5C0
PDB IDs
Enriched GO Terms of Interacting Partners?		Vesicle Fusion Membrane Fusion Organelle Fusion Vesicle-mediated Transport Membrane Organization Vesicle Organization Establishment Of Localization In Cell Cellular Localization Exocytosis Secretion By Cell Secretion Transport Golgi Vesicle Transport Protein Transport Establishment Of Protein Localization Protein Localization Intracellular Transport Neurotransmitter Secretion Regulation Of Exocytosis Regulation Of Cellular Localization Vesicle Docking Regulation Of Vesicle-mediated Transport Post-Golgi Vesicle-mediated Transport Membrane Docking Regulation Of Neurotransmitter Levels Intracellular Protein Transport Neurotransmitter Transport Synaptic Vesicle Exocytosis Vesicle Fusion With Golgi Apparatus Synaptic Vesicle Transport Cellular Protein Localization Regulation Of Secretion Establishment Of Vesicle Localization Vesicle Localization Cell-cell Signaling Organelle Organization Endomembrane System Organization Cytoplasmic Transport SNARE Complex Assembly Endosomal Transport Regulation Of Protein Localization To Plasma Membrane Synaptic Vesicle Fusion To Presynaptic Membrane Organelle Localization Establishment Of Organelle Localization Synaptic Transmission Golgi To Plasma Membrane Transport Regulation Of Protein Localization ER To Golgi Vesicle-mediated Transport Golgi To Plasma Membrane Protein Transport Positive Regulation Of Exocytosis	Synaptic Vesicle Fusion To Presynaptic Membrane Vesicle Fusion Synaptic Vesicle Exocytosis Organelle Fusion Neurotransmitter Secretion Synaptic Vesicle Transport Membrane Fusion Regulation Of Neurotransmitter Levels Neurotransmitter Transport Establishment Of Vesicle Localization Vesicle Organization Vesicle Localization Establishment Of Organelle Localization Exocytosis Organelle Localization Secretion By Cell Synaptic Transmission Positive Regulation Of Exocytosis Secretion Vesicle Docking Post-Golgi Vesicle-mediated Transport Membrane Docking Membrane Organization Cell-cell Signaling Positive Regulation Of Synaptic Transmission Regulation Of Exocytosis Regulation Of Insulin Secretion Protein Transport Vesicle-mediated Transport Positive Regulation Of Eosinophil Degranulation Establishment Of Protein Localization Regulation Of Peptide Hormone Secretion Intracellular Transport Regulation Of Hormone Secretion Golgi Vesicle Transport Regulation Of Synaptic Transmission Protein Localization Positive Regulation Of Secretion Cellular Protein Complex Assembly Establishment Of Localization In Cell Regulation Of Vesicle-mediated Transport Regulation Of Protein Secretion Positive Regulation Of Protein Localization To Cell Surface Positive Regulation Of Immunoglobulin Secretion Regulation Of Synaptic Vesicle Priming Synaptic Vesicle Docking Cellular Localization Synaptic Vesicle Priming SNARE Complex Assembly Histamine Secretion By Mast Cell
Tagcloud ?		address ageing armx3 b2mg consequence dep1 ebp50 effectors fact issue lancl1 maintaining modulators note ntal organismal pld3 preferentially recognize screened senescence senescent sorting straightforward triggering utilized vamp3 view vps26a	al355149 algorithm annotation array cisplatin dataset deregulated deregulation existing fam46a fluorouracil lnc lncrna lncrnas man1a2 mbl2 microdissected ncfans nodal noticed paclitaxel ppp2r4 reannotation reserve scc sprr2d tongue tumorigenic validate
Tagcloud (Difference) ?		address ageing armx3 b2mg consequence dep1 ebp50 effectors fact issue lancl1 maintaining modulators note ntal organismal pld3 preferentially recognize screened senescence senescent sorting straightforward triggering utilized vamp3 view vps26a	al355149 algorithm annotation array cisplatin dataset deregulated deregulation existing fam46a fluorouracil lnc lncrna lncrnas man1a2 mbl2 microdissected ncfans nodal noticed paclitaxel ppp2r4 reannotation reserve scc sprr2d tongue tumorigenic validate
Tagcloud (Intersection) ?