SEC22A and CYBRD1

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		SEC22A	CYBRD1
Description		SEC22 homolog A, vesicle trafficking protein	cytochrome b reductase 1
Image		No pdb structure
GO Annotations	Cellular Component	Cytoplasm Endoplasmic Reticulum Endoplasmic Reticulum Membrane Membrane	Lysosomal Membrane Plasma Membrane Membrane Apical Plasma Membrane Brush Border Membrane Extracellular Exosome
	Molecular Function	SNAP Receptor Activity Protein Binding	Protein Binding Oxidoreductase Activity Oxidoreductase Activity, Acting On Metal Ions Identical Protein Binding Metal Ion Binding Transmembrane Ascorbate Ferrireductase Activity Transmembrane Monodehydroascorbate Reductase Activity
	Biological Process	Endoplasmic Reticulum To Golgi Vesicle-mediated Transport Protein Transport Vesicle-mediated Transport Membrane Fusion	Intracellular Iron Ion Homeostasis Response To Iron Ion Reductive Iron Assimilation Transmembrane Transport Multicellular Organismal-level Iron Ion Homeostasis Ascorbate Homeostasis
Pathways		COPII-mediated vesicle transport	Iron uptake and transport
Drugs
Diseases
GWAS		Gestational age at birth (maternal effect) ( 28877031)	Appendicular lean mass ( 33097823) Asthma (childhood onset) ( 34022066) Body fat distribution (arm fat ratio) ( 30664634) Heel bone mineral density ( 30598549) Heel bone mineral density x serum urate levels interaction ( 34046847) Hip circumference adjusted for BMI ( 34021172) Pulse pressure ( 30224653) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172)
Interacting Genes		108 interacting genes: ADGRG3 AQP6 ASGR2 ATP6AP2 BIK BNIP3 C10orf67 C16orf54 C16orf92 CALN1 CD207 CD300A CD7 CD74 CISD2 CLEC10A CLEC12B CLEC2D CLEC7A CREB3L1 CYB561 CYBRD1 DDIT4L DIABLO DTX2 EDA ELOVL4 ERLIN1 ERVFRD-1 FAM174A FAM209A FATE1 FUT3 GAD2 GGT6 GJB5 GJB6 GPR37L1 GRAMD2B HAVCR2 HCST HSD17B11 ICAM3 KCNJ2 LDAF1 LDLRAD1 LHFPL5 LMNA LPAR6 LRRC25 LSMEM2 MCOLN1 MFF MGST2 MINAR1 MS4A14 MS4A3 MS4A4A MSR1 OPRM1 PACC1 PEX12 PHB1 PTGES RASGRP4 RETREG3 RILPL1 RNASEK RNF144A RNF19B RNF5 SAR1A SCN3B SDHAF2 SFTPC SLC10A1 SLC14A2 SLC18A1 SLC30A2 SLC35H1 SLC39A2 SMIM3 SPAG4 STMN4 STOML3 STX1A STX2 STX4 SUSD3 SYNE4 TFR2 TLCD4 TMED9 TMEM106C TMEM174 TMEM237 TMEM45B TMEM52B TMEM71 TMEM79 TMIE TMPRSS2 TNFSF14 TP53INP1 TRAT1 TRIM59 TYRP1 ZFYVE27	20 interacting genes: CREB3 FKBP8 GIMAP5 GOSR2 HMOX1 LMNA LPAR3 NEDD4L PLP2 RABAC1 SEC22A SERP1 SERP2 STX4 STX7 TMEM120A TMEM65 VAPA VAPB ZFPL1
Entrez ID		26984	79901
HPRD ID		15313	05764
Ensembl ID		ENSG00000121542	ENSG00000071967
Uniprot IDs		Q96IW7	Q53TN4
PDB IDs			5ZLE 5ZLG
Enriched GO Terms of Interacting Partners?		Membrane Protein Binding Plasma Membrane Endoplasmic Reticulum Membrane Endoplasmic Reticulum Lysosomal Membrane PH-gated Chloride Channel Activity Transmembrane Transport Pattern Recognition Receptor Activity Ascorbate Homeostasis Icosanoid Biosynthetic Process Endoplasmic Reticulum-autophagosome Adaptor Activity Transmembrane Monodehydroascorbate Reductase Activity D-mannose Binding	Endoplasmic Reticulum Membrane SNAP Receptor Activity Endoplasmic Reticulum Membrane Organization Membrane Fusion Endoplasmic Reticulum Unfolded Protein Response Organelle Localization By Membrane Tethering Membrane Docking Response To Unfolded Protein FFAT Motif Binding Membrane COPII-coated Vesicle Budding Endoplasmic Reticulum To Golgi Vesicle-mediated Transport Endoplasmic Reticulum-plasma Membrane Tethering SNARE Complex Vesicle Organization Vesicle-mediated Transport Endoplasmic Reticulum Localization SNARE Binding Host-mediated Activation Of Viral Genome Replication Host-mediated Perturbation Of Viral Genome Replication Host-mediated Suppression Of Viral Genome Replication Response To Endoplasmic Reticulum Stress Organelle Localization Vesicle Fusion Organelle Membrane Fusion Endomembrane System Intracellular Transport Golgi Vesicle Transport Organelle Fusion Viral Release From Host Cell Intracellular Protein Localization Endoplasmic Reticulum Exit Site Viral Process Vesicle Budding From Membrane Protein-membrane Adaptor Activity Regulation Of Extrinsic Apoptotic Signaling Pathway Host-mediated Activation Of Viral Process Positive Regulation Of Developmental Growth Regulation Of Protein Localization To Cell Surface Regulation Of Apoptotic Signaling Pathway Perinuclear Region Of Cytoplasm Cellular Localization Protein Transport Sphingomyelin Phosphodiesterase Activator Activity Positive Regulation Of Deacetylase Activity Establishment Of Localization In Cell Cellular Response To Stress Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Heme Oxidation
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