SEC22A and RNF5

Number of citations of the paper that reports this interaction (PubMedID 25416956)
56

Data Source:
BioGRID (two hybrid)

		SEC22A	RNF5
Description		SEC22 homolog A, vesicle trafficking protein	ring finger protein 5
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Cytoplasm Endoplasmic Reticulum Endoplasmic Reticulum Membrane Membrane	Mitochondrion Endoplasmic Reticulum Endoplasmic Reticulum Membrane Plasma Membrane Membrane Mitochondrial Membrane Endoplasmic Reticulum Quality Control Compartment
	Molecular Function	SNAP Receptor Activity Protein Binding	Ubiquitin-protein Transferase Activity Protein Binding Zinc Ion Binding Transferase Activity Identical Protein Binding Ubiquitin-like Protein Conjugating Enzyme Binding Protein-containing Complex Binding Metal Ion Binding Ubiquitin Protein Ligase Activity
	Biological Process	Endoplasmic Reticulum To Golgi Vesicle-mediated Transport Protein Transport Vesicle-mediated Transport Membrane Fusion	Ubiquitin-dependent Protein Catabolic Process Response To Bacterium Negative Regulation Of Autophagy Protein Ubiquitination Protein Catabolic Process Protein Destabilization ERAD Pathway Transmembrane Transport Protein K63-linked Ubiquitination Protein K48-linked Ubiquitination Endoplasmic Reticulum Mannose Trimming Regulation Of Autophagosome Assembly
Pathways		COPII-mediated vesicle transport	ABC-family proteins mediated transport Defective CFTR causes cystic fibrosis ER Quality Control Compartment (ERQC) AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274)
Drugs
Diseases
GWAS		Gestational age at birth (maternal effect) ( 28877031)	Asthma ( 31619474) Autism spectrum disorder or schizophrenia ( 28540026) Idiopathic membranous nephropathy ( 21323541) Inflammatory bowel disease ( 28067908) Itch intensity from mosquito bite adjusted by bite size ( 28199695) Prostate cancer ( 23535732) Soluble receptor for advanced glycation end-product levels ( 26083729) Ulcerative colitis ( 28067908) Waist circumference ( 31453325) Waist circumference variance ( 31453325)
Interacting Genes		108 interacting genes: ADGRG3 AQP6 ASGR2 ATP6AP2 BIK BNIP3 C10orf67 C16orf54 C16orf92 CALN1 CD207 CD300A CD7 CD74 CISD2 CLEC10A CLEC12B CLEC2D CLEC7A CREB3L1 CYB561 CYBRD1 DDIT4L DIABLO DTX2 EDA ELOVL4 ERLIN1 ERVFRD-1 FAM174A FAM209A FATE1 FUT3 GAD2 GGT6 GJB5 GJB6 GPR37L1 GRAMD2B HAVCR2 HCST HSD17B11 ICAM3 KCNJ2 LDAF1 LDLRAD1 LHFPL5 LMNA LPAR6 LRRC25 LSMEM2 MCOLN1 MFF MGST2 MINAR1 MS4A14 MS4A3 MS4A4A MSR1 OPRM1 PACC1 PEX12 PHB1 PTGES RASGRP4 RETREG3 RILPL1 RNASEK RNF144A RNF19B RNF5 SAR1A SCN3B SDHAF2 SFTPC SLC10A1 SLC14A2 SLC18A1 SLC30A2 SLC35H1 SLC39A2 SMIM3 SPAG4 STMN4 STOML3 STX1A STX2 STX4 SUSD3 SYNE4 TFR2 TLCD4 TMED9 TMEM106C TMEM174 TMEM237 TMEM45B TMEM52B TMEM71 TMEM79 TMIE TMPRSS2 TNFSF14 TP53INP1 TRAT1 TRIM59 TYRP1 ZFYVE27	54 interacting genes: ABHD16A ARL6IP1 CFTR CYB561 CYB561A3 DGAT2L6 EPHA2 EPHA3 EPHA4 FAM241B FHOD1 GLP1R INSIG2 JKAMP JMJD6 LEPROTL1 MPDZ MS4A1 ORMDL3 PGAM5 PLP2 PLPP6 PRAF2 PXN RABAC1 RHBDD1 RUSF1 SCD SEC22A SLC1A1 SLC38A7 TGFBR1 TMEM120B TMEM242 TNFAIP3 UBC UBE2D1 UBE2D2 UBE2D3 UBE2D4 UBE2E1 UBE2E2 UBE2E3 UBE2G2 UBE2K UBE2N UBE2U UBE2V1 UBE2W UBE2Z UBTD1 YIPF1 YIPF2 YIPF4
Entrez ID		26984	6048
HPRD ID		15313	04057
Ensembl ID		ENSG00000121542	ENSG00000204308
Uniprot IDs		Q96IW7	A0A024RCQ4 Q99942
PDB IDs
Enriched GO Terms of Interacting Partners?		Membrane Protein Binding Plasma Membrane Endoplasmic Reticulum Membrane Endoplasmic Reticulum Lysosomal Membrane PH-gated Chloride Channel Activity Transmembrane Transport Pattern Recognition Receptor Activity Ascorbate Homeostasis Icosanoid Biosynthetic Process Endoplasmic Reticulum-autophagosome Adaptor Activity Transmembrane Monodehydroascorbate Reductase Activity D-mannose Binding	Ubiquitin Conjugating Enzyme Activity Protein Polyubiquitination Protein K48-linked Ubiquitination Ubiquitin-protein Transferase Activity Protein Ubiquitination Protein Modification By Small Protein Conjugation Post-translational Protein Modification Protein Modification Process Proteolysis Involved In Protein Catabolic Process Protein Monoubiquitination ATP Binding Modification-dependent Protein Catabolic Process Protein K11-linked Ubiquitination Macromolecule Catabolic Process Transferase Activity Ubiquitin-dependent Protein Catabolic Process Protein Binding Proteolysis Nucleotide Binding Protein K63-linked Ubiquitination Protein Metabolic Process Fasciculation Of Motor Neuron Axon Ephrin Receptor Activity Catabolic Process Membrane Positive Regulation Of Protein Polyubiquitination Fasciculation Of Sensory Neuron Axon UBC13-MMS2 Complex ISG15 Transferase Activity Ubiquitin Conjugating Enzyme Complex Cellular Response To Stress Endoplasmic Reticulum Membrane Regulation Of Protein Polyubiquitination Endosome Proteasomal Protein Catabolic Process ISG15-protein Conjugation Cholesterol Biosynthetic Process GPI-linked Ephrin Receptor Activity Positive Regulation Of Protein K63-linked Ubiquitination Golgi Trans Cisterna Sterol Biosynthetic Process Golgi Medial Cisterna Ubiquitin Protein Ligase Binding Regulation Of Protein Ubiquitination Ephrin Receptor Signaling Pathway Transmembrane Receptor Protein Tyrosine Kinase Activity Positive Regulation Of Stress Fiber Assembly Protein Catabolic Process Endoplasmic Reticulum Regulation Of Protein K63-linked Ubiquitination
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