STX4 and BET1

Number of citations of the paper that reports this interaction (PubMedID 25416956)
56

Data Source:
BioGRID (two hybrid, two hybrid)

		STX4	BET1
Description		syntaxin 4	Bet1 golgi vesicular membrane trafficking protein
Image		No pdb structure
GO Annotations	Cellular Component	Storage Vacuole Extracellular Space Cytoplasm Endosome Vacuole Trans-Golgi Network Cytosol Plasma Membrane Cell Surface Endomembrane System Membrane Basolateral Plasma Membrane Lamellipodium Phagocytic Vesicle Membrane SNARE Complex Stereocilium Neuron Projection Membrane Myelin Sheath Adaxonal Region Somatodendritic Compartment Specific Granule Cell Projection Neuron Projection Dendritic Spine Lateral Loop Synapse Phagocytic Vesicle Perinuclear Region Of Cytoplasm Extracellular Exosome Schaffer Collateral - CA1 Synapse Postsynapse Glutamatergic Synapse	Golgi Membrane Endoplasmic Reticulum Endoplasmic Reticulum Membrane Golgi Apparatus Cis-Golgi Network Membrane Transport Vesicle SNARE Complex Endoplasmic Reticulum-Golgi Intermediate Compartment Membrane
	Molecular Function	SNARE Binding SNAP Receptor Activity Protein Binding Sphingomyelin Phosphodiesterase Activator Activity	SNAP Receptor Activity Protein Binding
	Biological Process	Positive Regulation Of Immunoglobulin Production Neurotransmitter Transport Intracellular Protein Transport Exocytosis Vesicle Fusion Sensory Perception Of Sound Positive Regulation Of Cell Population Proliferation Vesicle-mediated Transport Regulation Of Exocytosis Positive Regulation Of Cell Migration Protein Localization To Cell Surface Cellular Response To Oxidative Stress SNARE Complex Assembly Positive Regulation Of Insulin Secretion Involved In Cellular Response To Glucose Stimulus Positive Regulation Of Catalytic Activity Positive Regulation Of Eosinophil Degranulation Positive Regulation Of Cell Adhesion Vesicle Docking Organelle Fusion Positive Regulation Of Chemotaxis Long-term Synaptic Potentiation Membrane Organization Cellular Response To Type II Interferon Regulation Of Postsynaptic Membrane Neurotransmitter Receptor Levels Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Positive Regulation Of Protein Localization To Plasma Membrane Cornified Envelope Assembly Positive Regulation Of Protein Localization To Cell Surface	Endoplasmic Reticulum To Golgi Vesicle-mediated Transport Protein Transport Vesicle-mediated Transport Vesicle Fusion With Golgi Apparatus
Pathways		Disinhibition of SNARE formation ER-Phagosome pathway Translocation of SLC2A4 (GLUT4) to the plasma membrane trans-Golgi Network Vesicle Budding Other interleukin signaling	COPII-mediated vesicle transport COPI-mediated anterograde transport
Drugs
Diseases
GWAS		Response to metformin (IC50) ( 28173075) Triglyceride levels ( 32203549)	Aging ( 22773346) Asparaginase hypersensitivity in acute lymphoblastic leukemia ( 25987655) BRCA1/2-negative high-risk breast cancer ( 30323354) Obesity-related traits ( 23251661) World class endurance athleticism ( 26824906)
Interacting Genes		65 interacting genes: ABI2 ACTB ANKRD46 BET1 CYBRD1 DLG1 DNAJC5 FAXDC2 GIMAP5 GOSR2 GPR152 ITSN2 LLGL1 LMNA NAPA NAPB NSF PLP1 PSMA3 RAB11A RAB4A RAB5A RNF4 SCRIB SEC22A SEC22B SEPTIN5 SERP1 SGPL1 SH3GLB2 SNAP23 SNAP25 SNAP47 STX10 STX11 STX16 STX1A STX1B STX2 STX3 STX5 STXBP3 STXBP4 STXBP5 STXBP6 SYT1 SYT4 SYT7 TCEANC TMEM203 TRAF3IP3 TXLNA TXLNB TXLNG USE1 VAMP1 VAMP2 VAMP3 VAMP4 VAMP7 VAMP8 VAPB VMA12 VTI1B ZFPL1	57 interacting genes: ADORA2A ANKS6 AQP6 ASGR2 ASZ1 BCL2L13 BIK CD74 CD79A CGRRF1 CISD2 CLDN7 CLEC10A CRB3 CREB3L1 CYB561 CYB5R3 CYBC1 ELOVL4 ERGIC3 FAM174A FAM209A FAM210B FAM9B FKBP7 GPR152 GPX8 JAGN1 KASH5 KCNJ6 LYPD5 MAGEA6 MFF MGST3 NAPB PTGES REEP4 RETREG3 SAR1A SLC26A6 SLC35H1 SLC7A14 SNCA SNTG2 SSMEM1 STX1A STX1B STX2 STX4 STX5 TMCO5A TMEM237 TMEM35A TMEM52B TMEM80 TMX2 USHBP1
Entrez ID		6810	10282
HPRD ID		01722	16107
Ensembl ID		ENSG00000103496	ENSG00000105829
Uniprot IDs		B7Z425 Q12846	O15155 Q53XK0
PDB IDs			3EGX
Enriched GO Terms of Interacting Partners?		SNAP Receptor Activity SNARE Complex Membrane Fusion Syntaxin Binding Vesicle Fusion Organelle Membrane Fusion Organelle Fusion Vesicle-mediated Transport Membrane Organization SNARE Binding Vesicle Organization Exocytosis Organelle Localization By Membrane Tethering Establishment Of Localization In Cell Membrane Docking Secretion By Cell Vesicle Docking Protein Transport Secretion Establishment Of Protein Localization Vesicle-mediated Transport In Synapse Golgi Vesicle Transport Cellular Localization Intracellular Protein Localization Intracellular Transport Organelle Localization Regulation Of Vesicle-mediated Transport Endomembrane System Calcium-ion Regulated Exocytosis SNARE Complex Assembly Membrane Regulated Exocytosis Regulation Of Exocytosis Syntaxin-1 Binding Synaptic Vesicle Exocytosis Synaptic Vesicle Fusion To Presynaptic Active Zone Membrane Intracellular Protein Transport Vesicle Fusion To Plasma Membrane Regulation Of Secretion By Cell Synaptic Vesicle Membrane Regulation Of Secretion Synaptic Vesicle Membrane Organization Signal Release Regulation Of Transport Regulation Of Regulated Secretory Pathway Synaptic Vesicle Calcium Ion-regulated Exocytosis Of Neurotransmitter Vesicle Docking Involved In Exocytosis Synaptobrevin 2-SNAP-25-syntaxin-1a Complex Post-Golgi Vesicle-mediated Transport	Membrane Endoplasmic Reticulum Membrane SNARE Binding SNAP Receptor Activity Positive Regulation Of Neurotransmitter Secretion Protein Binding SNARE Complex Endoplasmic Reticulum Vesicle Docking Regulation Of Synaptic Vesicle Priming Organelle Localization By Membrane Tethering SNARE Complex Assembly Membrane Docking Vesicle Fusion Organelle Membrane Fusion Glutathione Peroxidase Activity Exocytosis Synaptobrevin 2-SNAP-25-syntaxin-1a Complex Mitochondrial Outer Membrane Organelle Fusion Presynaptic Active Zone Membrane Vesicle-mediated Transport Positive Regulation Of Synaptic Transmission Cornified Envelope Assembly Membrane Fusion Synaptic Vesicle Exocytosis Regulation Of Neurotransmitter Secretion Fucose Binding Prostanoid Metabolic Process Endomembrane System Unsaturated Fatty Acid Metabolic Process Regulation Of Catecholamine Secretion Secretion Neurotransmitter Transport Unsaturated Fatty Acid Biosynthetic Process Response To Type II Interferon Secretion By Cell Mitochondrial Membrane Icosanoid Biosynthetic Process Intracellular Protein Transport Synaptic Vesicle Fusion To Presynaptic Active Zone Membrane Positive Regulation Of Secretion By Cell Vesicle Fusion To Plasma Membrane Regulation Of Norepinephrine Secretion Vesicle Organization Synaptic Vesicle Docking Positive Regulation Of Secretion Organelle Localization Membrane Assembly Synaptic Transmission, Dopaminergic
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