SEC22A and RASGRP4

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		SEC22A	RASGRP4
Description		SEC22 homolog A, vesicle trafficking protein	RAS guanyl releasing protein 4
Image		No pdb structure
GO Annotations	Cellular Component	Cytoplasm Endoplasmic Reticulum Endoplasmic Reticulum Membrane Membrane	Nucleoplasm Cytoplasm Cytosol Plasma Membrane Cytoplasmic Side Of Plasma Membrane Membrane
	Molecular Function	SNAP Receptor Activity Protein Binding	Guanyl-nucleotide Exchange Factor Activity Calcium Ion Binding Protein Binding Zinc Ion Binding Lipid Binding Diacylglycerol Binding GTPase Regulator Activity Metal Ion Binding
	Biological Process	Endoplasmic Reticulum To Golgi Vesicle-mediated Transport Protein Transport Vesicle-mediated Transport Membrane Fusion	Positive Regulation Of Natural Killer Cell Mediated Immunity Phospholipase C-activating G Protein-coupled Receptor Signaling Pathway Small GTPase-mediated Signal Transduction Ras Protein Signal Transduction Myeloid Cell Differentiation Cell Differentiation Antibacterial Innate Immune Response
Pathways		COPII-mediated vesicle transport	FCERI mediated NF-kB activation RAF/MAP kinase cascade
Drugs
Diseases
GWAS		Gestational age at birth (maternal effect) ( 28877031)	Basophil count ( 32888494) Basophil percentage of white cells ( 32888494) Diisocyanate-induced asthma ( 25918132) Eosinophil count ( 27863252 32888494) Eosinophil percentage of white cells ( 27863252 32888494) Monocyte count ( 32888494) Neutrophil percentage of granulocytes ( 27863252) Sum eosinophil basophil counts ( 27863252)
Interacting Genes		108 interacting genes: ADGRG3 AQP6 ASGR2 ATP6AP2 BIK BNIP3 C10orf67 C16orf54 C16orf92 CALN1 CD207 CD300A CD7 CD74 CISD2 CLEC10A CLEC12B CLEC2D CLEC7A CREB3L1 CYB561 CYBRD1 DDIT4L DIABLO DTX2 EDA ELOVL4 ERLIN1 ERVFRD-1 FAM174A FAM209A FATE1 FUT3 GAD2 GGT6 GJB5 GJB6 GPR37L1 GRAMD2B HAVCR2 HCST HSD17B11 ICAM3 KCNJ2 LDAF1 LDLRAD1 LHFPL5 LMNA LPAR6 LRRC25 LSMEM2 MCOLN1 MFF MGST2 MINAR1 MS4A14 MS4A3 MS4A4A MSR1 OPRM1 PACC1 PEX12 PHB1 PTGES RASGRP4 RETREG3 RILPL1 RNASEK RNF144A RNF19B RNF5 SAR1A SCN3B SDHAF2 SFTPC SLC10A1 SLC14A2 SLC18A1 SLC30A2 SLC35H1 SLC39A2 SMIM3 SPAG4 STMN4 STOML3 STX1A STX2 STX4 SUSD3 SYNE4 TFR2 TLCD4 TMED9 TMEM106C TMEM174 TMEM237 TMEM45B TMEM52B TMEM71 TMEM79 TMIE TMPRSS2 TNFSF14 TP53INP1 TRAT1 TRIM59 TYRP1 ZFYVE27	6 interacting genes: BNIP2 DYNLL1 HRAS RAP1A SEC22A TMPRSS4
Entrez ID		26984	115727
HPRD ID		15313	09540
Ensembl ID		ENSG00000121542	ENSG00000171777
Uniprot IDs		Q96IW7	Q8TDF6
PDB IDs			6AXG
Enriched GO Terms of Interacting Partners?		Membrane Protein Binding Plasma Membrane Endoplasmic Reticulum Membrane Endoplasmic Reticulum Lysosomal Membrane PH-gated Chloride Channel Activity Transmembrane Transport Pattern Recognition Receptor Activity Ascorbate Homeostasis Icosanoid Biosynthetic Process Endoplasmic Reticulum-autophagosome Adaptor Activity Transmembrane Monodehydroascorbate Reductase Activity D-mannose Binding	Regulation Of Receptor Localization To Synapse Regulation Of Protein Localization To Synapse Regulation Of Neurotransmitter Receptor Localization To Postsynaptic Specialization Membrane Positive Regulation Of MAPK Cascade GDP Binding G Protein Activity Negative Regulation Of Growth Rate Regulation Of Cellular Localization GTPase Complex Response To Antineoplastic Agent Negative Regulation Of DNA Strand Resection Involved In Replication Fork Processing Secretory Granule Regulation Of MAPK Cascade Phospholipase C Activator Activity Deoxyribonuclease Inhibitor Activity Regulation Of DNA Strand Resection Involved In Replication Fork Processing Nitric-oxide Synthase Inhibitor Activity Perinuclear Region Of Cytoplasm Regulation Of Protein Localization To Cell Periphery Positive Regulation Of Cell Communication Positive Regulation Of Signaling Regulation Of Protein Localization To Membrane Positive Regulation Of ERK1 And ERK2 Cascade Regulation Of Growth Rate Positive Regulation Of Fc Receptor Mediated Stimulatory Signaling Pathway Negative Regulation Of Synaptic Vesicle Exocytosis Apoptotic Process Oncogene-induced Cell Senescence Cell Development Guanyl-nucleotide Exchange Factor Complex Cell Death Programmed Cell Death Regulation Of Protein Localization Nitric-oxide Synthase Regulator Activity Positive Regulation Of Intracellular Signal Transduction Spindle Pole Centrosome Response To Oxygen-glucose Deprivation GTPase Activity Regulation Of ERK1 And ERK2 Cascade Vesicle-mediated Transport Positive Regulation Of Ruffle Assembly Small GTPase-mediated Signal Transduction T-helper 1 Type Immune Response Positive Regulation Of Establishment Of Protein Localization Negative Regulation Of Collagen Biosynthetic Process Cellular Response To Forskolin Rap Protein Signal Transduction Positive Regulation Of Vasculogenesis Nerve Growth Factor Signaling Pathway Regulation Of Fc Receptor Mediated Stimulatory Signaling Pathway
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