SEC22A and MCOLN1

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		SEC22A	MCOLN1
Description		SEC22 homolog A, vesicle trafficking protein	mucolipin TRP cation channel 1
Image		No pdb structure
GO Annotations	Cellular Component	Cytoplasm Endoplasmic Reticulum Endoplasmic Reticulum Membrane Membrane	Phagocytic Cup Nucleoplasm Lysosome Lysosomal Membrane Endosome Late Endosome Golgi Apparatus Plasma Membrane Endosome Membrane Membrane Cytoplasmic Vesicle Membrane Phagocytic Vesicle Membrane Cytoplasmic Vesicle Late Endosome Membrane Cell Projection Receptor Complex
	Molecular Function	SNAP Receptor Activity Protein Binding	Monoatomic Anion Channel Activity Monoatomic Cation Channel Activity Calcium Channel Activity Potassium Channel Activity Sodium Channel Activity Iron Ion Transmembrane Transporter Activity Protein Binding Lipid Binding Identical Protein Binding NAADP-sensitive Calcium-release Channel Activity Intracellularly Phosphatidylinositol-3,5-bisphosphate-gated Monatomic Cation Channel Activity Ligand-gated Calcium Channel Activity
	Biological Process	Endoplasmic Reticulum To Golgi Vesicle-mediated Transport Protein Transport Vesicle-mediated Transport Membrane Fusion	Adaptive Immune Response Immune System Process Monoatomic Ion Transport Monoatomic Cation Transport Calcium Ion Transport Lysosome Organization Calcium-mediated Signaling Transferrin Transport Monoatomic Ion Transmembrane Transport Iron Ion Transmembrane Transport Sodium Ion Transmembrane Transport Negative Regulation Of Innate Immune Response Release Of Sequestered Calcium Ion Into Cytosol Protein Homotetramerization Calcium Ion Transmembrane Transport Cellular Response To Calcium Ion Cellular Response To PH Potassium Ion Transmembrane Transport Phagosome Maturation Autophagosome Maturation Monoatomic Cation Transmembrane Transport Monoatomic Anion Transmembrane Transport Antibacterial Innate Immune Response Negative Regulation Of Protein Localization To Nucleus Positive Regulation Of Protein Localization To Nucleus Calcium Ion Export Positive Regulation Of Lysosome Organization
Pathways		COPII-mediated vesicle transport	TRP channels Transferrin endocytosis and recycling
Drugs
Diseases			Mucolipidosis IV
GWAS		Gestational age at birth (maternal effect) ( 28877031)	Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Mean platelet volume ( 32888494) Opioid overdose severity score ( 31362332)
Interacting Genes		108 interacting genes: ADGRG3 AQP6 ASGR2 ATP6AP2 BIK BNIP3 C10orf67 C16orf54 C16orf92 CALN1 CD207 CD300A CD7 CD74 CISD2 CLEC10A CLEC12B CLEC2D CLEC7A CREB3L1 CYB561 CYBRD1 DDIT4L DIABLO DTX2 EDA ELOVL4 ERLIN1 ERVFRD-1 FAM174A FAM209A FATE1 FUT3 GAD2 GGT6 GJB5 GJB6 GPR37L1 GRAMD2B HAVCR2 HCST HSD17B11 ICAM3 KCNJ2 LDAF1 LDLRAD1 LHFPL5 LMNA LPAR6 LRRC25 LSMEM2 MCOLN1 MFF MGST2 MINAR1 MS4A14 MS4A3 MS4A4A MSR1 OPRM1 PACC1 PEX12 PHB1 PTGES RASGRP4 RETREG3 RILPL1 RNASEK RNF144A RNF19B RNF5 SAR1A SCN3B SDHAF2 SFTPC SLC10A1 SLC14A2 SLC18A1 SLC30A2 SLC35H1 SLC39A2 SMIM3 SPAG4 STMN4 STOML3 STX1A STX2 STX4 SUSD3 SYNE4 TFR2 TLCD4 TMED9 TMEM106C TMEM174 TMEM237 TMEM45B TMEM52B TMEM71 TMEM79 TMIE TMPRSS2 TNFSF14 TP53INP1 TRAT1 TRIM59 TYRP1 ZFYVE27	5 interacting genes: APPBP2 GPR35 SEC22A SLC35E1 TRIM27
Entrez ID		26984	57192
HPRD ID		15313	05582
Ensembl ID		ENSG00000121542	ENSG00000090674
Uniprot IDs		Q96IW7	Q9GZU1
PDB IDs			5TJA 5TJB 5TJC 5WJ5 5WJ9 6E7P 6E7Y 6E7Z 7MGL
Enriched GO Terms of Interacting Partners?		Membrane Protein Binding Plasma Membrane Endoplasmic Reticulum Membrane Endoplasmic Reticulum Lysosomal Membrane PH-gated Chloride Channel Activity Transmembrane Transport Pattern Recognition Receptor Activity Ascorbate Homeostasis Icosanoid Biosynthetic Process Endoplasmic Reticulum-autophagosome Adaptor Activity Transmembrane Monodehydroascorbate Reductase Activity D-mannose Binding
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