SEC22A and SLC18A1

Number of citations of the paper that reports this interaction (PubMedID 36949045)
82

Data Source:
BioGRID (two hybrid)

		SEC22A	SLC18A1
Description		SEC22 homolog A, vesicle trafficking protein	solute carrier family 18 member A1
Image		No pdb structure
GO Annotations	Cellular Component	Cytoplasm Endoplasmic Reticulum Endoplasmic Reticulum Membrane Membrane	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Membrane Transport Vesicle Membrane Secretory Granule Membrane Synaptic Vesicle Membrane Cytoplasmic Vesicle Terminal Bouton Synapse Clathrin-sculpted Monoamine Transport Vesicle Membrane Presynapse
	Molecular Function	SNAP Receptor Activity Protein Binding	Serotonin:sodium:chloride Symporter Activity Protein Binding Monoamine Transmembrane Transporter Activity Monoamine:proton Antiporter Activity Transmembrane Transporter Activity Xenobiotic Transmembrane Transporter Activity
	Biological Process	Endoplasmic Reticulum To Golgi Vesicle-mediated Transport Protein Transport Vesicle-mediated Transport Membrane Fusion	Neurotransmitter Transport Serotonin Transport Aminergic Neurotransmitter Loading Into Synaptic Vesicle Monoamine Transport Dopamine Transport Xenobiotic Transport Serotonin Uptake Norepinephrine Uptake Establishment Of Localization In Cell Transmembrane Transport Dopamine Uptake Proton Transmembrane Transport
Pathways		COPII-mediated vesicle transport
Drugs			Reserpine Norepinephrine Ephedra sinica root MMDA Metamfetamine
Diseases
GWAS		Gestational age at birth (maternal effect) ( 28877031)	Apolipoprotein A1 levels ( 32203549) Cholesterol ( 31902109) Gut microbiota (bacterial taxa, hurdle binary method) ( 32572223) HDL cholesterol levels ( 32203549) Hypertriglyceridemia ( 23505323) Major depressive disorder (broad) ( 20038947) Metabolic syndrome ( 30382898 31589552) Persistent hepatitis B virus infection ( 27244555) Pulse pressure ( 27841878) Response to selenium supplementation (change in plasma selenium concentration) ( 33382417) Systolic blood pressure ( 27841878) Triglyceride levels ( 32203549) Triglyceride levels in HIV infection ( 33109212) Triglycerides ( 18193046 24886709)
Interacting Genes		108 interacting genes: ADGRG3 AQP6 ASGR2 ATP6AP2 BIK BNIP3 C10orf67 C16orf54 C16orf92 CALN1 CD207 CD300A CD7 CD74 CISD2 CLEC10A CLEC12B CLEC2D CLEC7A CREB3L1 CYB561 CYBRD1 DDIT4L DIABLO DTX2 EDA ELOVL4 ERLIN1 ERVFRD-1 FAM174A FAM209A FATE1 FUT3 GAD2 GGT6 GJB5 GJB6 GPR37L1 GRAMD2B HAVCR2 HCST HSD17B11 ICAM3 KCNJ2 LDAF1 LDLRAD1 LHFPL5 LMNA LPAR6 LRRC25 LSMEM2 MCOLN1 MFF MGST2 MINAR1 MS4A14 MS4A3 MS4A4A MSR1 OPRM1 PACC1 PEX12 PHB1 PTGES RASGRP4 RETREG3 RILPL1 RNASEK RNF144A RNF19B RNF5 SAR1A SCN3B SDHAF2 SFTPC SLC10A1 SLC14A2 SLC18A1 SLC30A2 SLC35H1 SLC39A2 SMIM3 SPAG4 STMN4 STOML3 STX1A STX2 STX4 SUSD3 SYNE4 TFR2 TLCD4 TMED9 TMEM106C TMEM174 TMEM237 TMEM45B TMEM52B TMEM71 TMEM79 TMIE TMPRSS2 TNFSF14 TP53INP1 TRAT1 TRIM59 TYRP1 ZFYVE27	88 interacting genes: ADGRE2 AGTRAP ANKRD46 APOL2 BRICD5 BTN2A2 C1GALT1 C2CD2L CCL4 CCL4L2 CD81 CNIH1 COL4A5 CTSA CXCL16 CYB561D2 ERMP1 FAM3C FCER1G FXYD3 GIMAP1 GJB2 GPR151 HTATIP2 INSIG2 LAT MALL MARCHF2 MFSD6 MGAM MGLL MIP MS4A1 MS4A13 NEU1 NRM OLFM4 ORMDL1 PEX16 PLP1 PLP2 PMP22 PNLIPRP1 RABAC1 RPRM SCD SEC22A SELENOK SERP1 SLC30A2 SLC30A3 SLC30A8 SLC35B4 SLC35G1 SLC38A7 SLC39A2 SMCO4 SMIM1 STX2 STX7 STX8 SYNGR1 TECR TFRC TMEM120B TMEM128 TMEM147 TMEM14A TMEM14B TMEM14C TMEM203 TMEM218 TMEM239 TMEM42 TMEM60 TMEM65 TMEM86A TMEM97 TSPO2 UPK1B UPK2 VAMP5 VAPA VAPB VTI1B YIPF1 YIPF4 YIPF6
Entrez ID		26984	6570
HPRD ID		15313	01897
Ensembl ID		ENSG00000121542	ENSG00000036565
Uniprot IDs		Q96IW7	P54219 Q96GL6
PDB IDs			8TGG 8TGH 8TGI 8TGJ 8TGK 8TGL 8TGM 8TGN
Enriched GO Terms of Interacting Partners?		Membrane Protein Binding Plasma Membrane Endoplasmic Reticulum Membrane Endoplasmic Reticulum Lysosomal Membrane PH-gated Chloride Channel Activity Transmembrane Transport Pattern Recognition Receptor Activity Ascorbate Homeostasis Icosanoid Biosynthetic Process Endoplasmic Reticulum-autophagosome Adaptor Activity Transmembrane Monodehydroascorbate Reductase Activity D-mannose Binding	Membrane Endoplasmic Reticulum Membrane Endoplasmic Reticulum Plasma Membrane Membrane Docking Protein Binding SNAP Receptor Activity Organelle Localization By Membrane Tethering Chloride Channel Inhibitor Activity Membrane Organization Zinc Ion Transmembrane Transporter Activity Vesicle-mediated Transport Zinc Ion Transmembrane Transport Zinc Ion Transport Membrane Fusion Zinc Ion Import Into Organelle Cellular Localization Endomembrane System FFAT Motif Binding Monoatomic Cation Transmembrane Transporter Activity SNARE Complex Zinc Ion Import Into Lysosome Vesicle Fusion Organelle Membrane Fusion Lysosome Zinc:proton Antiporter Activity COPII-coated Vesicle Budding Endoplasmic Reticulum-plasma Membrane Tethering Vesicle Docking Establishment Of Localization In Cell Vesicle SNARE Binding Intracellular Transport Fatty Acid Biosynthetic Process Gap Junction-mediated Intercellular Transport Cytoplasmic Vesicle Endoplasmic Reticulum To Golgi Vesicle-mediated Transport Positive Regulation Of Protein Catabolic Process In The Vacuole Endoplasmic Reticulum Localization Vesicle Fusion With Golgi Apparatus Organelle Fusion Golgi Vesicle Transport Transmembrane Transport Lysosomal Membrane Vacuolar Transmembrane Transport Synaptic Vesicle Golgi Trans Cisterna Secretory Vesicle Golgi Medial Cisterna Metal Ion Transport
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