SEC22A and HAVCR2

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		SEC22A	HAVCR2
Description		SEC22 homolog A, vesicle trafficking protein	hepatitis A virus cellular receptor 2
Image		No pdb structure
GO Annotations	Cellular Component	Cytoplasm Endoplasmic Reticulum Endoplasmic Reticulum Membrane Membrane	Immunological Synapse Early Endosome Plasma Membrane Cell Surface Membrane Mediator Complex Anchoring Junction
	Molecular Function	SNAP Receptor Activity Protein Binding	Transmembrane Signaling Receptor Activity Protein Binding Metal Ion Binding
	Biological Process	Endoplasmic Reticulum To Golgi Vesicle-mediated Transport Protein Transport Vesicle-mediated Transport Membrane Fusion	Positive Regulation Of Cytokine Production Adaptive Immune Response Macrophage Activation Involved In Immune Response Immune System Process Natural Killer Cell Tolerance Induction Regulation Of Tolerance Induction Dependent Upon Immune Response Negative Regulation Of T-helper 1 Type Immune Response Negative Regulation Of Immune Response To Tumor Cell Negative Regulation Of Natural Killer Cell Mediated Cytotoxicity Directed Against Tumor Cell Target Regulation Of Transcription By RNA Polymerase II Inflammatory Response Negative Regulation Of Gene Expression Negative Regulation Of Myeloid Dendritic Cell Activation Negative Regulation Of NF-kappaB Transcription Factor Activity Negative Regulation Of Type I Interferon Production Negative Regulation Of Interferon-alpha Production Negative Regulation Of Type II Interferon Production Negative Regulation Of Interleukin-2 Production Negative Regulation Of Interleukin-3 Production Negative Regulation Of Interleukin-6 Production Negative Regulation Of Tumor Necrosis Factor Production Positive Regulation Of Chemokine Production Positive Regulation Of Type II Interferon Production Positive Regulation Of Interleukin-1 Production Positive Regulation Of Interleukin-4 Production Positive Regulation Of Tumor Necrosis Factor Production Negative Regulation Of Natural Killer Cell Activation Toll-like Receptor 3 Signaling Pathway Toll-like Receptor 7 Signaling Pathway Toll-like Receptor 9 Signaling Pathway Positive Regulation Of T Cell Proliferation Negative Regulation Of T Cell Proliferation Positive Regulation Of Macrophage Activation Innate Immune Response Positive Regulation Of Innate Immune Response Negative Regulation Of Innate Immune Response Defense Response To Gram-positive Bacterium Maternal Process Involved In Female Pregnancy Positive Regulation Of ERK1 And ERK2 Cascade Cellular Response To Lipopolysaccharide Negative Regulation Of Granulocyte Colony-stimulating Factor Production Negative Regulation Of Defense Response To Bacterium Positive Regulation Of Defense Response To Bacterium Positive Regulation Of Non-canonical NF-kappaB Signal Transduction Negative Regulation Of Immunological Synapse Formation Negative Regulation Of T Cell Activation Via T Cell Receptor Contact With Antigen Bound To MHC Molecule On Antigen Presenting Cell
Pathways		COPII-mediated vesicle transport	Interleukin-2 family signaling
Drugs
Diseases
GWAS		Gestational age at birth (maternal effect) ( 28877031)	Blood protein levels ( 30072576) Hypertriglyceridemia ( 23505323) Iris heterochromicity ( 30895295)
Interacting Genes		108 interacting genes: ADGRG3 AQP6 ASGR2 ATP6AP2 BIK BNIP3 C10orf67 C16orf54 C16orf92 CALN1 CD207 CD300A CD7 CD74 CISD2 CLEC10A CLEC12B CLEC2D CLEC7A CREB3L1 CYB561 CYBRD1 DDIT4L DIABLO DTX2 EDA ELOVL4 ERLIN1 ERVFRD-1 FAM174A FAM209A FATE1 FUT3 GAD2 GGT6 GJB5 GJB6 GPR37L1 GRAMD2B HAVCR2 HCST HSD17B11 ICAM3 KCNJ2 LDAF1 LDLRAD1 LHFPL5 LMNA LPAR6 LRRC25 LSMEM2 MCOLN1 MFF MGST2 MINAR1 MS4A14 MS4A3 MS4A4A MSR1 OPRM1 PACC1 PEX12 PHB1 PTGES RASGRP4 RETREG3 RILPL1 RNASEK RNF144A RNF19B RNF5 SAR1A SCN3B SDHAF2 SFTPC SLC10A1 SLC14A2 SLC18A1 SLC30A2 SLC35H1 SLC39A2 SMIM3 SPAG4 STMN4 STOML3 STX1A STX2 STX4 SUSD3 SYNE4 TFR2 TLCD4 TMED9 TMEM106C TMEM174 TMEM237 TMEM45B TMEM52B TMEM71 TMEM79 TMIE TMPRSS2 TNFSF14 TP53INP1 TRAT1 TRIM59 TYRP1 ZFYVE27	3 interacting genes: APP SEC22A TMEM86A
Entrez ID		26984	84868
HPRD ID		15313	16227
Ensembl ID		ENSG00000121542	ENSG00000135077
Uniprot IDs		Q96IW7	Q8TDQ0
PDB IDs			5DZL 5F71 6DHB 6TXZ 7KQL 7M3Y 7M3Z 7M41 8HGJ 8TBB 8TFT
Enriched GO Terms of Interacting Partners?		Membrane Protein Binding Plasma Membrane Endoplasmic Reticulum Membrane Endoplasmic Reticulum Lysosomal Membrane PH-gated Chloride Channel Activity Transmembrane Transport Pattern Recognition Receptor Activity Ascorbate Homeostasis Icosanoid Biosynthetic Process Endoplasmic Reticulum-autophagosome Adaptor Activity Transmembrane Monodehydroascorbate Reductase Activity D-mannose Binding	Acetylcholine Receptor Activator Activity Amyloid-beta Complex PTB Domain Binding Growth Cone Lamellipodium Collateral Sprouting In Absence Of Injury Regulation Of Protein Import Regulation Of Response To Calcium Ion Amylin Binding Endosome To Plasma Membrane Transport Vesicle Protein Tetramerization Positive Regulation Of Toll Signaling Pathway Positive Regulation Of Endothelin Production Growth Cone Filopodium Lipoprotein Particle Phospholipase D-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Protein Import Microglia Development Positive Regulation Of G Protein-coupled Receptor Internalization Stress-induced Mitochondrial Fusion TRNA Guanylyltransferase Activity Regulation Of Transcriptional Start Site Selection At RNA Polymerase II Promoter NuRD Complex Binding Alkenylglycerophosphocholine Hydrolase Activity Response To Norepinephrine Regulation Of Endoplasmic Reticulum Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Cellular Response To Norepinephrine Stimulus Astrocyte Activation Involved In Immune Response Low-density Lipoprotein Particle Mediated Signaling Intermediate-density Lipoprotein Particle Axon Midline Choice Point Recognition Positive Regulation Of Amyloid Fibril Formation Growth Factor Receptor Binding Main Axon Protein Homooligomerization Regulation Of Spontaneous Synaptic Transmission NMDA Selective Glutamate Receptor Signaling Pathway Regulation Of Synapse Structure Or Activity Regulation Of Toll Signaling Pathway Axon Choice Point Recognition Histone H3K36me3 Reader Activity Heparan Sulfate Binding Signaling Receptor Activator Activity Peptidase Activator Activity Protein Complex Oligomerization Cellular Response To Manganese Ion Antifungal Humoral Response Nuclear Envelope Lumen
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