PTPRB and NRCAM

Number of citations of the paper that reports this interaction (PMID 9049255)
26

Data Source:
BioGRID (pull down)
HPRD (in vivo)

		PTPRB	NRCAM
Gene Name		protein tyrosine phosphatase, receptor type, B	neuronal cell adhesion molecule
Image
Gene Ontology Annotations	Cellular Component	Integral Component Of Plasma Membrane Receptor Complex	Plasma Membrane Integral Component Of Plasma Membrane External Side Of Plasma Membrane Neuron Projection Axon Initial Segment Synapse
	Molecular Function	Transmembrane Receptor Protein Tyrosine Phosphatase Activity Protein Binding	Protein Binding Ankyrin Binding Protein Binding Involved In Heterotypic Cell-cell Adhesion
	Biological Process	Angiogenesis Protein Dephosphorylation Phosphate-containing Compound Metabolic Process Dephosphorylation Peptidyl-tyrosine Dephosphorylation	Angiogenesis Neuron Migration Axonogenesis Axon Guidance Axonal Fasciculation Synapse Assembly Central Nervous System Development Protein Localization Single Organismal Cell-cell Adhesion Neuronal Action Potential Propagation Regulation Of Axon Extension Retinal Ganglion Cell Axon Guidance Heterotypic Cell-cell Adhesion Clustering Of Voltage-gated Sodium Channels Positive Regulation Of Neuron Differentiation
Pathways			Interaction between L1 and Ankyrins Axon guidance Neurofascin interactions L1CAM interactions NrCAM interactions
Drugs
Diseases
GWAS			Coffee consumption ( 21876539) Femoral neck bone geometry and menarche (age at onset) ( 23593202)
Protein-Protein Interactions		10 interactors: CDH5 CNTN1 CNTNAP1 F11R GHR MAGI3 MET NRCAM TEK TNC	8 interactors: ANK2 CNTN2 HSPA12A LNX1 MACF1 MAGI3 NFASC PTPRB
Entrez ID		5787	4897
HPRD ID		01474	07207
Ensembl ID		ENSG00000127329	ENSG00000091129
Uniprot IDs		B7ZKS8 F5H3G6 P23467 Q86VA4	B7Z670 Q14CA1 Q92823
PDB IDs		2AHS 2H02 2H03 2H04 2HC1 2HC2 2I3R 2I3U 2I4E 2I4G 2I4H 2I5X	1UEN 1UEY
Enriched GO Terms of Interacting Partners?		Cell Adhesion Signaling Cell Communication Cell Development Axon Development Locomotion Neuronal Action Potential Propagation Cell Morphogenesis Involved In Differentiation Neuron Projection Development Movement Of Cell Or Subcellular Component Axon Guidance Mesenchymal-epithelial Cell Signaling Enzyme Linked Receptor Protein Signaling Pathway Neuron Development Positive Regulation Of MAPK Cascade Response To Stimulus Positive Regulation Of Kinase Activity Cell Morphogenesis Axonogenesis Neuron Differentiation Cell Projection Organization Positive Regulation Of Transferase Activity Cell Junction Assembly Cell Morphogenesis Involved In Neuron Differentiation Chemotaxis Cellular Response To Stimulus Cell-cell Junction Organization Positive Regulation Of MAP Kinase Activity Regulation Of MAPK Cascade Positive Regulation Of Signal Transduction Neuron Projection Morphogenesis Anatomical Structure Development Cell Differentiation Positive Regulation Of Metabolic Process Regulation Of Establishment Or Maintenance Of Cell Polarity Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Regulation Of Actin Cytoskeleton Reorganization Positive Regulation Of Protein Phosphorylation Anatomical Structure Morphogenesis Signal Transduction Endothelial Cell Development Positive Regulation Of Protein Serine/threonine Kinase Activity Peptidyl-tyrosine Phosphorylation Regulation Of MAP Kinase Activity Positive Regulation Of Catalytic Activity Regulation Of Kinase Activity Generation Of Neurons Developmental Process Positive Regulation Of Intracellular Signal Transduction Transmission Of Nerve Impulse	Protein Localization To Juxtaparanode Region Of Axon Neuronal Ion Channel Clustering Paranodal Junction Assembly Myelination Axon Ensheathment Neuron Maturation Myelin Assembly Membrane Organization Axon Guidance Anatomical Structure Formation Involved In Morphogenesis Establishment Of Protein Localization To Plasma Membrane Establishment Of Protein Localization To Juxtaparanode Region Of Axon Protein Localization To T-tubule Anatomical Structure Morphogenesis Axonogenesis Cellular Protein Localization Protein Localization To M-band Positive Regulation Of Adenosine Receptor Signaling Pathway T-tubule Organization Cell-cell Junction Assembly Axon Development Cell Morphogenesis Involved In Neuron Differentiation Protein Localization To Endoplasmic Reticulum Chemotaxis Movement Of Cell Or Subcellular Component Neuron Projection Morphogenesis Clustering Of Voltage-gated Potassium Channels Generation Of Neurons Cell Maturation Protein Localization To Plasma Membrane Regulation Of Axonogenesis Protein Targeting To Membrane Neurogenesis Cell Morphogenesis Involved In Differentiation Membrane Depolarization During SA Node Cell Action Potential Cell Junction Assembly SA Node Cell Action Potential Neuron Projection Development Cell-cell Junction Organization Cell Projection Morphogenesis Clustering Of Voltage-gated Sodium Channels Regulation Of Axon Diameter Protein Localization Cell Part Morphogenesis Plasma Membrane Organization Posttranslational Protein Targeting To Membrane Regulation Of Cardiac Muscle Cell Membrane Potential Establishment Of Protein Localization To Membrane Cerebral Cortex GABAergic Interneuron Migration Atrial Cardiac Muscle Cell Action Potential
Tagcloud ?		accumulative acknowledged astrocytoma chi3l1 chr1 chr22 clustering crocc daughter discover ecm exome gbm hereditary lymphatic multiforme narrow pilocytic players pms2 pontine predisposition proximity q12 siblings snvs striking synonymous underline	affects clustering disorganization dorsal erbb2 erbb3 ganglion glaucoma gliomedin implicate littermates myelin myelination myocilin nav1 nerve nerves neurofascin nodal nodes null ocular ranvier root schwann sciatic sheath stimulates thickness
Tagcloud (Difference) ?		accumulative acknowledged astrocytoma chi3l1 chr1 chr22 crocc daughter discover ecm exome gbm hereditary lymphatic multiforme narrow pilocytic players pms2 pontine predisposition proximity q12 siblings snvs striking synonymous underline	affects disorganization dorsal erbb2 erbb3 ganglion glaucoma gliomedin implicate littermates myelin myelination myocilin nav1 nerve nerves neurofascin nodal nodes null ocular ranvier root schwann sciatic sheath stimulates thickness
Tagcloud (Intersection) ?		clustering