GREM1 and YWHAH

Number of citations of the paper that reports this interaction (PMID 16545136)
21

Data Source:
HPRD (in vitro, two hybrid)

		GREM1	YWHAH
Gene Name		gremlin 1, DAN family BMP antagonist	tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, eta
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Extracellular Space Cell Surface	Cytoplasm Cytosol Plasma Membrane Intercalated Disc Cytoplasmic Vesicle Membrane Extracellular Vesicular Exosome
	Molecular Function	Cytokine Activity Protein Binding Morphogen Activity Transmembrane Receptor Protein Tyrosine Kinase Activator Activity BMP Binding Vascular Endothelial Growth Factor Receptor 2 Binding Receptor Agonist Activity	Actin Binding Insulin-like Growth Factor Receptor Binding Protein Binding Sodium Channel Regulator Activity Enzyme Binding Protein Domain Specific Binding Glucocorticoid Receptor Binding Ion Channel Binding Protein Heterodimerization Activity
	Biological Process	Cell Morphogenesis Branching Involved In Ureteric Bud Morphogenesis Cell Migration Involved In Sprouting Angiogenesis Positive Regulation Of Receptor Internalization Positive Regulation Of Transcription From RNA Polymerase II Promoter Involved In Myocardial Precursor Cell Differentiation Mesenchymal To Epithelial Transition Involved In Metanephros Morphogenesis Apoptotic Process Signal Transduction Activation Of Transmembrane Receptor Protein Tyrosine Kinase Activity Cell-cell Signaling Positive Regulation Of Cell Proliferation Proximal/distal Pattern Formation Regulation Of Epithelial To Mesenchymal Transition Collagen Fibril Organization Negative Regulation Of Cell Growth Embryonic Limb Morphogenesis Negative Regulation Of Bone Mineralization Negative Regulation Of BMP Signaling Pathway Negative Regulation Of Chondrocyte Differentiation Regulation Of Stress-activated MAPK Cascade Negative Regulation Of Osteoblast Proliferation Positive Regulation Of NF-kappaB Import Into Nucleus Negative Regulation Of Apoptotic Process Positive Regulation Of Angiogenesis Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription From RNA Polymerase II Promoter Negative Regulation Of Bone Remodeling Determination Of Dorsal Identity Positive Regulation Of NF-kappaB Transcription Factor Activity Regulation Of Focal Adhesion Assembly Positive Regulation Of Telomerase Activity Limb Development Negative Regulation Of Pathway-restricted SMAD Protein Phosphorylation Ureteric Bud Formation Positive Regulation Of Protein Tyrosine Kinase Activity Signal Transduction By P53 Class Mediator Negative Regulation Of Monocyte Chemotaxis Negative Regulation Of Canonical Wnt Signaling Pathway Positive Regulation Of Branching Involved In Ureteric Bud Morphogenesis Negative Regulation Of Branching Involved In Ureteric Bud Morphogenesis Negative Regulation Of Osteoclast Proliferation Positive Regulation Of Peptidyl-tyrosine Autophosphorylation Negative Regulation Of Bone Trabecula Formation Negative Regulation Of Bone Mineralization Involved In Bone Maturation Positive Regulation Of Receptor Activity Positive Regulation Of Cardiac Muscle Cell Differentiation	Regulation Of Sodium Ion Transport Glucocorticoid Catabolic Process Intracellular Protein Transport Apoptotic Process Substantia Nigra Development Glucocorticoid Receptor Signaling Pathway Regulation Of Neuron Differentiation Positive Regulation Of Transcription, DNA-templated Regulation Of Synaptic Plasticity Negative Regulation Of Dendrite Morphogenesis Membrane Organization Membrane Depolarization During Action Potential Intrinsic Apoptotic Signaling Pathway Positive Regulation Of Protein Insertion Into Mitochondrial Membrane Involved In Apoptotic Signaling Pathway Regulation Of Sodium Ion Transmembrane Transporter Activity
Pathways			Activation of BAD and translocation to mitochondria Programmed Cell Death Translocation of GLUT4 to the plasma membrane Activation of BH3-only proteins Intrinsic Pathway for Apoptosis
Drugs
Diseases
GWAS		Colorectal cancer ( 21761138 23266556) Orofacial clefts ( 20023658)
Protein-Protein Interactions		2 interactors: BMP2 YWHAH	61 interactors: ABL1 ARHGEF28 BAD BCR BRAF CDC25B CDC25C CDK16 CDKN1B CHRNA4 CREBBP EPB41L2 EPB41L3 ESR1 ESR2 EXO1 GREM1 ING1 KCNH2 KCNK15 KCNK3 KCNK9 KIF5B KLC3 KRT18 MAP3K3 MAP3K5 MARK4 MDM4 MED1 MST1R NCOA1 NCOA2 NCOA3 NEK1 NR3C1 NRIP1 PARD3 PARD6A PARD6B PARK2 PDPK1 PRKCI PTH1R RAF1 REM1 RIMS1 RIMS2 RPH3A SAMSN1 SNCA SRC THRA TLX2 TNFAIP3 TPH1 TSC1 TSC2 YWHAE YWHAG ZFP36
Entrez ID		26585	7533
HPRD ID		07048	00215
Ensembl ID		ENSG00000166923	ENSG00000128245
Uniprot IDs		A6XAA7 B3KTR9 O60565	Q04917 Q9H4N8
PDB IDs			2C63 2C74
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Wnt Signaling Pathway By BMP Signaling Pathway Negative Regulation Of Calcium-independent Cell-cell Adhesion Glucocorticoid Catabolic Process Corticotropin Hormone Secreting Cell Differentiation BMP Signaling Pathway Involved In Heart Induction Thyroid-stimulating Hormone-secreting Cell Differentiation Negative Regulation Of Cortisol Biosynthetic Process Negative Regulation Of Aldosterone Biosynthetic Process BMP Signaling Pathway Involved In Heart Development Mesenchymal Cell Proliferation Involved In Ureteric Bud Development Regulation Of Cell Morphogenesis Negative Regulation Of Wnt Signaling Pathway Involved In Heart Development Bone Mineralization Involved In Bone Maturation Negative Regulation Of Cardiac Muscle Cell Differentiation Embryonic Heart Tube Anterior/posterior Pattern Specification Neuroendocrine Cell Differentiation Negative Regulation Of Glucocorticoid Biosynthetic Process Regulation Of Neuron Differentiation Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Glucocorticoid Receptor Signaling Pathway Negative Regulation Of Insulin-like Growth Factor Receptor Signaling Pathway Positive Regulation Of P38MAPK Cascade Negative Regulation Of Dendrite Morphogenesis Positive Regulation Of Cell Death Negative Regulation Of Steroid Hormone Biosynthetic Process Positive Regulation Of Astrocyte Differentiation Regulation Of Glucocorticoid Biosynthetic Process Negative Regulation Of Hormone Biosynthetic Process Positive Regulation Of Osteoblast Proliferation Positive Regulation Of Odontogenesis Regulation Of Neurogenesis Regulation Of Glucocorticoid Metabolic Process Negative Regulation Of Cell Differentiation Brain Development Pathway-restricted SMAD Protein Phosphorylation Adenohypophysis Development Head Development Telencephalon Regionalization Cell Proliferation Involved In Kidney Development Regulation Of P38MAPK Cascade Negative Regulation Of Dendrite Development Regulation Of Cell Development Ossification Involved In Bone Maturation Regulation Of Odontogenesis Of Dentin-containing Tooth Mesenchymal Cell Proliferation Glucocorticoid Metabolic Process Bone Maturation Negative Regulation Of Striated Muscle Cell Differentiation Atrioventricular Valve Morphogenesis	Signaling Cell Communication Regulation Of Kinase Activity Anatomical Structure Development Developmental Process Cellular Response To Organic Substance Positive Regulation Of Metabolic Process Signal Transduction Regulation Of Phosphorus Metabolic Process System Development Multicellular Organismal Development Regulation Of Protein Phosphorylation Cellular Response To Stimulus Regulation Of Cell Death Regulation Of Protein Kinase Activity Regulation Of Cellular Process Response To Organic Substance Regulation Of Phosphorylation Regulation Of Cellular Localization Positive Regulation Of Cellular Metabolic Process Regulation Of Signaling Response To Stimulus Intracellular Receptor Signaling Pathway Regulation Of Apoptotic Process Intracellular Steroid Hormone Receptor Signaling Pathway Response To Hormone Cellular Response To Hormone Stimulus Regulation Of Signal Transduction Regulation Of Cellular Protein Metabolic Process Regulation Of Protein Metabolic Process Negative Regulation Of Protein Metabolic Process Enzyme Linked Receptor Protein Signaling Pathway Intracellular Signal Transduction Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Negative Regulation Of Cellular Protein Metabolic Process Regulation Of Cellular Component Organization Regulation Of Catalytic Activity Anatomical Structure Morphogenesis Regulation Of Cell Proliferation Regulation Of Metabolic Process Negative Regulation Of Protein Phosphorylation Organelle Organization Cell Cycle Negative Regulation Of Cellular Metabolic Process Response To Organonitrogen Compound Apoptotic Process Cellular Response To Growth Factor Stimulus Positive Regulation Of Programmed Cell Death Programmed Cell Death Response To Growth Factor
Tagcloud ?		aire amh articles bmp15 dor epigenetics esr1 etiology expose fertility fmr1 foxl2 fshr gdf9 gpr3 idiopathic igf1 igf2 igf2r lhcgr multifactorial november pathologic premature pubmed reserve seeking translocations wnt4	3eta 3gamma accumulates add bipolar clumped deformed deionized eggs localizes maturation matured meiosis meiotic metaphase microinjected microtubules morpholino oligonucleotide oocyte oocytes proximity reproduction spindle spindles tubulin uninjected visualization
Tagcloud (Difference) ?		aire amh articles bmp15 dor epigenetics esr1 etiology expose fertility fmr1 foxl2 fshr gdf9 gpr3 idiopathic igf1 igf2 igf2r lhcgr multifactorial november pathologic premature pubmed reserve seeking translocations wnt4	3eta 3gamma accumulates add bipolar clumped deformed deionized eggs localizes maturation matured meiosis meiotic metaphase microinjected microtubules morpholino oligonucleotide oocyte oocytes proximity reproduction spindle spindles tubulin uninjected visualization
Tagcloud (Intersection) ?