GREM1 and YWHAH

Number of citations of the paper that reports this interaction (PubMedID 16545136)
47

Data Source:
HPRD (two hybrid, in vitro)

		GREM1	YWHAH
Description		gremlin 1, DAN family BMP antagonist	tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein eta
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GO Annotations	Cellular Component	Extracellular Region Extracellular Space Cell Surface Extracellular Matrix	Cytoplasm Mitochondrion Cytosol Plasma Membrane Intercalated Disc Synapse Extracellular Exosome Presynapse Glutamatergic Synapse Cerebellar Granule Cell To Purkinje Cell Synapse
	Molecular Function	Cytokine Activity Protein Binding Morphogen Activity Transmembrane Receptor Protein Tyrosine Kinase Activator Activity BMP Binding Protein Homodimerization Activity Vascular Endothelial Growth Factor Receptor 2 Binding Receptor Ligand Activity	Actin Binding Insulin-like Growth Factor Receptor Binding Protein Binding Sodium Channel Regulator Activity Enzyme Binding Protein Domain Specific Binding Nuclear Glucocorticoid Receptor Binding Identical Protein Binding Transmembrane Transporter Binding Protein Heterodimerization Activity
	Biological Process	Cell Morphogenesis Angiogenesis Cell Migration Involved In Sprouting Angiogenesis Positive Regulation Of Receptor Internalization Mesenchymal To Epithelial Transition Involved In Metanephros Morphogenesis Signal Transduction Cell-cell Signaling Positive Regulation Of Cell Population Proliferation Animal Organ Morphogenesis Proximal/distal Pattern Formation Regulation Of Epithelial To Mesenchymal Transition Collagen Fibril Organization Embryonic Limb Morphogenesis Negative Regulation Of Bone Mineralization Negative Regulation Of BMP Signaling Pathway Negative Regulation Of Chondrocyte Differentiation Regulation Of Stress-activated MAPK Cascade Negative Regulation Of Osteoblast Proliferation Sequestering Of BMP From Receptor Via BMP Binding Negative Regulation Of Apoptotic Process Endothelial Cell Migration Negative Regulation Of Osteoblast Differentiation Positive Regulation Of Angiogenesis Negative Regulation Of DNA-templated Transcription Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Bone Remodeling Determination Of Dorsal Identity Regulation Of Focal Adhesion Assembly Cardiac Muscle Cell Differentiation Limb Development Cardiac Muscle Cell Myoblast Differentiation Negative Regulation Of SMAD Protein Signal Transduction Ureteric Bud Formation Signal Transduction By P53 Class Mediator Negative Regulation Of Monocyte Chemotaxis Positive Regulation Of Cell Migration Involved In Sprouting Angiogenesis Negative Regulation Of Canonical Wnt Signaling Pathway Positive Regulation Of Branching Involved In Ureteric Bud Morphogenesis Negative Regulation Of Osteoclast Proliferation Negative Regulation Of Bone Trabecula Formation Negative Regulation Of Bone Mineralization Involved In Bone Maturation Positive Regulation Of Vascular Endothelial Growth Factor Signaling Pathway Positive Regulation Of Non-canonical NF-kappaB Signal Transduction	Regulation Of Sodium Ion Transport Glucocorticoid Catabolic Process Intracellular Protein Transport Signal Transduction Intracellular Protein Localization Substantia Nigra Development Nuclear Receptor-mediated Glucocorticoid Signaling Pathway Regulation Of Neuron Differentiation Positive Regulation Of DNA-templated Transcription Regulation Of Synaptic Plasticity Negative Regulation Of Dendrite Morphogenesis Membrane Depolarization During Action Potential Presynaptic Modulation Of Chemical Synaptic Transmission
Pathways		Formation of the ureteric bud	Activation of BAD and translocation to mitochondria Translocation of SLC2A4 (GLUT4) to the plasma membrane RHO GTPases activate PKNs TP53 Regulates Metabolic Genes Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex SARS-CoV-1 targets host intracellular signalling and regulatory pathways SARS-CoV-2 targets host intracellular signalling and regulatory pathways Transcriptional and post-translational regulation of MITF-M expression and activity
Drugs			Phenethyl Isothiocyanate
Diseases
GWAS		Chin dimples ( 27182965) Colorectal cancer ( 21761138 23266556 24737748 25990418 26151821) Colorectal cancer or advanced adenoma ( 30510241) Haemorrhoidal disease ( 33888516) Hypospadias ( 25108383) Metabolite levels ( 23823483) Monobrow ( 27182965) Orofacial clefts ( 20023658)	Post bronchodilator FEV1 ( 26634245) Type 2 diabetes ( 30297969)
Interacting Genes		4 interacting genes: BMP2 KRTAP12-2 MDFI YWHAH	69 interacting genes: ABL1 ARHGEF28 BAD BCR BRAF CCDC125 CDC25B CDC25C CDC42 CDK16 CDKN1B CHRNA4 CREBBP EPB41L2 EPB41L3 ESR1 ESR2 EXO1 GREM1 HSPB1 ILF3 ING1 KANK1 KCNH2 KCNK15 KCNK3 KCNK9 KLC3 KRT18 MAP3K3 MAP3K5 MARK4 MDM4 MED1 MST1R NCAM2 NCOA1 NCOA2 NCOA3 NEDD4L NEK1 NHSL2 NR3C1 NRIP1 PARD3 PARD6A PARD6B PCNT PDPK1 PRKCI PRKN PTH1R RAF1 REM1 RIMS1 RIMS2 RPH3A SAMSN1 SNCA SRC THRA TLX2 TNFAIP3 TPH1 TSC1 TSC2 YWHAE YWHAG ZFP36
Entrez ID		26585	7533
HPRD ID		07048	00215
Ensembl ID		ENSG00000166923	ENSG00000128245
Uniprot IDs		A6XAA7 B3KTR9 O60565	Q04917 Q9H4N8
PDB IDs		5AEJ 8B7H	2C63 2C74 7NMZ
Enriched GO Terms of Interacting Partners?		Embryonic Heart Tube Anterior/posterior Pattern Specification Regulation Of Extracellular Matrix Constituent Secretion Regulation Of Wnt Signaling Pathway Negative Regulation Of Aldosterone Biosynthetic Process Regulation Of Cortisol Biosynthetic Process Regulation Of Aldosterone Biosynthetic Process Positive Regulation Of Dephosphorylation Negative Regulation Of Wnt Signaling Pathway Pericardium Development Cardiac Jelly Development Thyroid-stimulating Hormone-secreting Cell Differentiation Heart Induction Cardiac Atrium Formation Negative Regulation Of Cortisol Biosynthetic Process Ameloblast Differentiation Regulation Of Neuron Differentiation Positive Regulation Of Odontogenesis Telencephalon Regionalization Negative Regulation Of Steroid Hormone Biosynthetic Process Semi-lunar Valve Development Positive Regulation Of Phosphatase Activity Negative Regulation Of Glucocorticoid Biosynthetic Process Positive Regulation Of Bone Mineralization Involved In Bone Maturation Positive Regulation Of Odontoblast Differentiation Aortic Valve Development Endodermal-mesodermal Cell Signaling Negative Regulation Of Insulin-like Growth Factor Receptor Signaling Pathway Positive Regulation Of Neuroepithelial Cell Differentiation Atrioventricular Canal Morphogenesis Negative Regulation Of Calcium-independent Cell-cell Adhesion Mesenchymal Cell Proliferation Involved In Ureteric Bud Development Positive Regulation Of Extracellular Matrix Constituent Secretion Regulation Of Odontogenesis Of Dentin-containing Tooth Regulation Of Heart Morphogenesis Enzyme Activator Complex Corticotropin Hormone Secreting Cell Differentiation Regulation Of Phosphatase Activity Phosphatase Activator Activity BMP Receptor Complex Negative Regulation Of Dendrite Morphogenesis Nuclear Receptor-mediated Glucocorticoid Signaling Pathway Nuclear Receptor-mediated Corticosteroid Signaling Pathway Glucocorticoid Catabolic Process Cerebellar Granule Cell To Purkinje Cell Synapse Cell Proliferation Involved In Kidney Development Regulation Of Glucocorticoid Biosynthetic Process Negative Regulation Of Cardiac Muscle Cell Differentiation Positive Regulation Of Peroxisome Proliferator Activated Receptor Signaling Pathway Regulation Of Odontoblast Differentiation Co-receptor Binding	Intracellular Signal Transduction Nuclear Receptor-mediated Signaling Pathway Cytosol Regulation Of Cell Communication Regulation Of Signaling Regulation Of Programmed Cell Death Regulation Of Signal Transduction Intracellular Receptor Signaling Pathway Regulation Of Developmental Process Regulation Of Biological Quality PAR Polarity Complex Regulation Of Intracellular Signal Transduction Regulation Of Transport Signal Transduction Positive Regulation Of Signal Transduction Positive Regulation Of Cell Communication Positive Regulation Of Signaling Protein Phosphorylation Regulation Of Membrane Potential Regulation Of Apoptotic Process Regulation Of Vesicle-mediated Transport Cell Junction Organization Negative Regulation Of Apoptotic Process Phosphorylation Positive Regulation Of Metabolic Process Enzyme Binding Negative Regulation Of Programmed Cell Death Positive Regulation Of Macromolecule Metabolic Process Regulation Of Multicellular Organismal Process Response To Lipid Cellular Response To Hormone Stimulus Hormone-mediated Signaling Pathway Positive Regulation Of Transport Positive Regulation Of Developmental Process Positive Regulation Of Protein Localization Protein Kinase Binding Regulation Of Anatomical Structure Morphogenesis Developmental Process Cytoskeleton Organization Cellular Response To Lipid Positive Regulation Of Intracellular Signal Transduction Regulation Of Secretion By Cell Regulation Of Phosphorus Metabolic Process Regulation Of Protein Localization Positive Regulation Of Biosynthetic Process Protein Serine/threonine Kinase Activity Synaptic Vesicle Priming Steroid Hormone Receptor Signaling Pathway Nuclear Receptor-mediated Steroid Hormone Signaling Pathway Protein Kinase Activity
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