GREM1

Gene Name		gremlin 1, DAN family BMP antagonist
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Extracellular Space Cell Surface
	Molecular Function	Cytokine Activity Protein Binding Morphogen Activity Transmembrane Receptor Protein Tyrosine Kinase Activator Activity BMP Binding Vascular Endothelial Growth Factor Receptor 2 Binding Receptor Agonist Activity
	Biological Process	Cell Morphogenesis Branching Involved In Ureteric Bud Morphogenesis Cell Migration Involved In Sprouting Angiogenesis Positive Regulation Of Receptor Internalization Positive Regulation Of Transcription From RNA Polymerase II Promoter Involved In Myocardial Precursor Cell Differentiation Mesenchymal To Epithelial Transition Involved In Metanephros Morphogenesis Apoptotic Process Signal Transduction Activation Of Transmembrane Receptor Protein Tyrosine Kinase Activity Cell-cell Signaling Positive Regulation Of Cell Proliferation Proximal/distal Pattern Formation Regulation Of Epithelial To Mesenchymal Transition Collagen Fibril Organization Negative Regulation Of Cell Growth Embryonic Limb Morphogenesis Negative Regulation Of Bone Mineralization Negative Regulation Of BMP Signaling Pathway Negative Regulation Of Chondrocyte Differentiation Regulation Of Stress-activated MAPK Cascade Negative Regulation Of Osteoblast Proliferation Positive Regulation Of NF-kappaB Import Into Nucleus Negative Regulation Of Apoptotic Process Positive Regulation Of Angiogenesis Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription From RNA Polymerase II Promoter Negative Regulation Of Bone Remodeling Determination Of Dorsal Identity Positive Regulation Of NF-kappaB Transcription Factor Activity Regulation Of Focal Adhesion Assembly Positive Regulation Of Telomerase Activity Limb Development Negative Regulation Of Pathway-restricted SMAD Protein Phosphorylation Ureteric Bud Formation Positive Regulation Of Protein Tyrosine Kinase Activity Signal Transduction By P53 Class Mediator Negative Regulation Of Monocyte Chemotaxis Negative Regulation Of Canonical Wnt Signaling Pathway Positive Regulation Of Branching Involved In Ureteric Bud Morphogenesis Negative Regulation Of Branching Involved In Ureteric Bud Morphogenesis Negative Regulation Of Osteoclast Proliferation Positive Regulation Of Peptidyl-tyrosine Autophosphorylation Negative Regulation Of Bone Trabecula Formation Negative Regulation Of Bone Mineralization Involved In Bone Maturation Positive Regulation Of Receptor Activity Positive Regulation Of Cardiac Muscle Cell Differentiation
Pathways
Drugs
Diseases
GWAS		Colorectal cancer ( 21761138 23266556) Orofacial clefts ( 20023658)
Protein-protein Interactions		2 interactors: BMP2 YWHAH
Entrez ID		26585
HPRD ID		07048
Ensembl ID		ENSG00000166923
Uniprot IDs		A6XAA7 B3KTR9 O60565
PDB IDs
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Wnt Signaling Pathway By BMP Signaling Pathway Negative Regulation Of Calcium-independent Cell-cell Adhesion Glucocorticoid Catabolic Process Corticotropin Hormone Secreting Cell Differentiation BMP Signaling Pathway Involved In Heart Induction Thyroid-stimulating Hormone-secreting Cell Differentiation Negative Regulation Of Cortisol Biosynthetic Process Negative Regulation Of Aldosterone Biosynthetic Process BMP Signaling Pathway Involved In Heart Development Mesenchymal Cell Proliferation Involved In Ureteric Bud Development Regulation Of Cell Morphogenesis Negative Regulation Of Wnt Signaling Pathway Involved In Heart Development Bone Mineralization Involved In Bone Maturation Negative Regulation Of Cardiac Muscle Cell Differentiation Embryonic Heart Tube Anterior/posterior Pattern Specification Neuroendocrine Cell Differentiation Negative Regulation Of Glucocorticoid Biosynthetic Process Regulation Of Neuron Differentiation Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Glucocorticoid Receptor Signaling Pathway Negative Regulation Of Insulin-like Growth Factor Receptor Signaling Pathway Positive Regulation Of P38MAPK Cascade Negative Regulation Of Dendrite Morphogenesis Positive Regulation Of Cell Death Negative Regulation Of Steroid Hormone Biosynthetic Process Positive Regulation Of Astrocyte Differentiation Regulation Of Glucocorticoid Biosynthetic Process Negative Regulation Of Hormone Biosynthetic Process Positive Regulation Of Osteoblast Proliferation Positive Regulation Of Odontogenesis Regulation Of Neurogenesis Regulation Of Glucocorticoid Metabolic Process Negative Regulation Of Cell Differentiation Brain Development Pathway-restricted SMAD Protein Phosphorylation Adenohypophysis Development Head Development Telencephalon Regionalization Cell Proliferation Involved In Kidney Development Regulation Of P38MAPK Cascade Negative Regulation Of Dendrite Development Regulation Of Cell Development Ossification Involved In Bone Maturation Regulation Of Odontogenesis Of Dentin-containing Tooth Mesenchymal Cell Proliferation Glucocorticoid Metabolic Process Bone Maturation Negative Regulation Of Striated Muscle Cell Differentiation Atrioventricular Valve Morphogenesis
Tagcloud ?		aire amh articles bmp15 dor epigenetics esr1 etiology expose fertility fmr1 foxl2 fshr gdf9 gpr3 idiopathic igf1 igf2 igf2r lhcgr multifactorial november pathologic premature pubmed reserve seeking translocations wnt4