GREM1

Description		gremlin 1, DAN family BMP antagonist
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GO Annotations	Cellular Component	Extracellular Region Extracellular Space Cell Surface Extracellular Matrix
	Molecular Function	Cytokine Activity Protein Binding Morphogen Activity Transmembrane Receptor Protein Tyrosine Kinase Activator Activity BMP Binding Protein Homodimerization Activity Vascular Endothelial Growth Factor Receptor 2 Binding Receptor Ligand Activity
	Biological Process	Cell Morphogenesis Angiogenesis Cell Migration Involved In Sprouting Angiogenesis Positive Regulation Of Receptor Internalization Mesenchymal To Epithelial Transition Involved In Metanephros Morphogenesis Signal Transduction Cell-cell Signaling Positive Regulation Of Cell Population Proliferation Animal Organ Morphogenesis Proximal/distal Pattern Formation Regulation Of Epithelial To Mesenchymal Transition Collagen Fibril Organization Embryonic Limb Morphogenesis Negative Regulation Of Bone Mineralization Negative Regulation Of BMP Signaling Pathway Negative Regulation Of Chondrocyte Differentiation Regulation Of Stress-activated MAPK Cascade Negative Regulation Of Osteoblast Proliferation Sequestering Of BMP From Receptor Via BMP Binding Negative Regulation Of Apoptotic Process Endothelial Cell Migration Negative Regulation Of Osteoblast Differentiation Positive Regulation Of Angiogenesis Negative Regulation Of DNA-templated Transcription Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Bone Remodeling Determination Of Dorsal Identity Regulation Of Focal Adhesion Assembly Cardiac Muscle Cell Differentiation Limb Development Cardiac Muscle Cell Myoblast Differentiation Negative Regulation Of SMAD Protein Signal Transduction Ureteric Bud Formation Signal Transduction By P53 Class Mediator Negative Regulation Of Monocyte Chemotaxis Positive Regulation Of Cell Migration Involved In Sprouting Angiogenesis Negative Regulation Of Canonical Wnt Signaling Pathway Positive Regulation Of Branching Involved In Ureteric Bud Morphogenesis Negative Regulation Of Osteoclast Proliferation Negative Regulation Of Bone Trabecula Formation Negative Regulation Of Bone Mineralization Involved In Bone Maturation Positive Regulation Of Vascular Endothelial Growth Factor Signaling Pathway Positive Regulation Of Non-canonical NF-kappaB Signal Transduction
Pathways		Formation of the ureteric bud
Drugs
Diseases
GWAS		Chin dimples ( 27182965) Colorectal cancer ( 21761138 23266556 24737748 25990418 26151821) Colorectal cancer or advanced adenoma ( 30510241) Haemorrhoidal disease ( 33888516) Hypospadias ( 25108383) Metabolite levels ( 23823483) Monobrow ( 27182965) Orofacial clefts ( 20023658)
Interacting Genes		4 interacting genes: BMP2 KRTAP12-2 MDFI YWHAH
Entrez ID		26585
HPRD ID		07048
Ensembl ID		ENSG00000166923
Uniprot IDs		A6XAA7 B3KTR9 O60565
PDB IDs		5AEJ 8B7H
Enriched GO Terms of Interacting Partners?		Embryonic Heart Tube Anterior/posterior Pattern Specification Regulation Of Extracellular Matrix Constituent Secretion Regulation Of Wnt Signaling Pathway Negative Regulation Of Aldosterone Biosynthetic Process Regulation Of Cortisol Biosynthetic Process Regulation Of Aldosterone Biosynthetic Process Positive Regulation Of Dephosphorylation Negative Regulation Of Wnt Signaling Pathway Pericardium Development Cardiac Jelly Development Thyroid-stimulating Hormone-secreting Cell Differentiation Heart Induction Cardiac Atrium Formation Negative Regulation Of Cortisol Biosynthetic Process Ameloblast Differentiation Regulation Of Neuron Differentiation Positive Regulation Of Odontogenesis Telencephalon Regionalization Negative Regulation Of Steroid Hormone Biosynthetic Process Semi-lunar Valve Development Positive Regulation Of Phosphatase Activity Negative Regulation Of Glucocorticoid Biosynthetic Process Positive Regulation Of Bone Mineralization Involved In Bone Maturation Positive Regulation Of Odontoblast Differentiation Aortic Valve Development Endodermal-mesodermal Cell Signaling Negative Regulation Of Insulin-like Growth Factor Receptor Signaling Pathway Positive Regulation Of Neuroepithelial Cell Differentiation Atrioventricular Canal Morphogenesis Negative Regulation Of Calcium-independent Cell-cell Adhesion Mesenchymal Cell Proliferation Involved In Ureteric Bud Development Positive Regulation Of Extracellular Matrix Constituent Secretion Regulation Of Odontogenesis Of Dentin-containing Tooth Regulation Of Heart Morphogenesis Enzyme Activator Complex Corticotropin Hormone Secreting Cell Differentiation Regulation Of Phosphatase Activity Phosphatase Activator Activity BMP Receptor Complex Negative Regulation Of Dendrite Morphogenesis Nuclear Receptor-mediated Glucocorticoid Signaling Pathway Nuclear Receptor-mediated Corticosteroid Signaling Pathway Glucocorticoid Catabolic Process Cerebellar Granule Cell To Purkinje Cell Synapse Cell Proliferation Involved In Kidney Development Regulation Of Glucocorticoid Biosynthetic Process Negative Regulation Of Cardiac Muscle Cell Differentiation Positive Regulation Of Peroxisome Proliferator Activated Receptor Signaling Pathway Regulation Of Odontoblast Differentiation Co-receptor Binding
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