AATF and MYCBP2

Number of citations of the paper that reports this interaction (PubMedID 21653829)
54

Data Source:
BioGRID (two hybrid)

		AATF	MYCBP2
Description		apoptosis antagonizing transcription factor	MYC binding protein 2
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Transcription Regulator Complex Nucleolus Cytoplasm Small-subunit Processome	Nucleus Nucleoplasm Cytoplasm Cytosol Cytoskeleton Plasma Membrane Microtubule Cytoskeleton Membrane Axon Cell Projection
	Molecular Function	RNA Binding Protein Binding Leucine Zipper Domain Binding	Guanyl-nucleotide Exchange Factor Activity Protein Binding Zinc Ion Binding Transferase Activity Small GTPase Binding Identical Protein Binding Metal Ion Binding Ubiquitin Protein Ligase Activity
	Biological Process	Cell Adhesion Regulation Of Mitotic Cell Cycle Embryonic Cleavage Ribosome Biogenesis Ribosomal Small Subunit Biogenesis Negative Regulation Of Amyloid Precursor Protein Biosynthetic Process Negative Regulation Of Apoptotic Signaling Pathway	Axon Guidance Motor Neuron Axon Guidance Regulation Of Synaptic Assembly At Neuromuscular Junction Protein Ubiquitination Branchiomotor Neuron Axon Guidance Central Nervous System Projection Neuron Axonogenesis Positive Regulation Of Protein Ubiquitination Regulation Of Protein Localization Circadian Regulation Of Gene Expression Negative Regulation Of Protein Catabolic Process Rhythmic Process Cell Morphogenesis Involved In Neuron Differentiation Neuromuscular Process Regulation Of Cytoskeleton Organization Axon Development Protein K48-linked Ubiquitination Regulation Of Axon Guidance
Pathways		NRAGE signals death through JNK
Drugs
Diseases
GWAS		Body mass index ( 26426971) Erectile dysfunction ( 30583798) Obesity-related traits ( 23251661) Thyroid volume in Hashimoto’s thyroiditis ( 32019955)	Chronotype ( 30696823) Iris heterochromicity ( 30895295) Morning person ( 30696823) Preeclampsia ( 23551011) Tourette's syndrome or obsessive-compulsive disorder ( 25158072)
Interacting Genes		29 interacting genes: ATM ATR AURKA CHEK1 CHEK2 CPD DAPK3 DAZAP2 EFNB3 FBXO7 HIPK2 LDOC1 LZTR1 MAPT MPHOSPH6 MYCBP2 NEDD4L PALS2 PARP1 PAWR PCBD2 POLR2J RB1 RELA SMAD3 SP1 SS18L1 TSG101 ZNF468	50 interacting genes: AATF APPL1 ARL6IP5 ASB8 ATP13A2 BTG3 CALM1 CD81 CEBPA CFL1 CUEDC2 DHRS4L2 DSCR9 DYRK1A ERBB3 FHL3 FSCN1 HSP90AB1 HUNK IGFBP6 LCOR LDHB LSM14A MYC NDUFB9 NMNAT2 OAZ1 PABPN1 PI4KB PRXL2A PTPN12 PUF60 RGPD8 RPS5 RSPH1 SERPINB6 SOD1 SPARCL1 SPRYD3 SRPK2 TBC1D9 TBC1D9B TBR1 TTN UBE2D2 UBE2D3 UBE2L3 UCHL1 YWHAG YWHAQ
Entrez ID		26574	23077
HPRD ID		12236	10104
Ensembl ID		ENSG00000275700	ENSG00000005810
Uniprot IDs		A0A7P0TAR0 A0A7P0TBG4 Q9NY61	O75592
PDB IDs		5W6A 7MQ8 7MQ9	5O6C 6T7F
Enriched GO Terms of Interacting Partners?		Ubiquitin Protein Ligase Binding Regulation Of Protein Metabolic Process Replicative Senescence Positive Regulation Of Metabolic Process Response To Gamma Radiation Regulation Of Cell Communication Regulation Of Signaling Regulation Of Signal Transduction By P53 Class Mediator Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Macromolecule Metabolic Process Regulation Of Primary Metabolic Process Cellular Response To Oxygen-containing Compound Regulation Of Signal Transduction Regulation Of Macromolecule Metabolic Process Positive Regulation Of Macromolecule Metabolic Process Regulation Of Cellular Component Organization Signal Transduction Involved In Regulation Of Gene Expression Negative Regulation Of Metabolic Process Regulation Of Metabolic Process Negative Regulation Of Gene Expression Regulation Of Gene Expression Negative Regulation Of Macromolecule Biosynthetic Process Regulation Of Apoptotic Process Regulation Of Organelle Organization Negative Regulation Of Protein Metabolic Process Negative Regulation Of Biosynthetic Process Regulation Of Programmed Cell Death PML Body Chromatin Organization Establishment Of RNA Localization To Telomere Establishment Of Protein-containing Complex Localization To Telomere Regulation Of Mitotic Nuclear Division Regulation Of Cellular Response To Heat Negative Regulation Of Mitotic Cell Cycle Positive Regulation Of Telomerase Catalytic Core Complex Assembly G2/M Transition Of Mitotic Cell Cycle Regulation Of Developmental Process Regulation Of Anatomical Structure Morphogenesis Protein Serine Kinase Activity Negative Regulation Of Cell Cycle Phase Transition Regulation Of Mitotic Cell Cycle Protein Kinase Activity Cell Cycle G2/M Phase Transition Apoptotic Process Protein Homodimerization Activity Positive Regulation Of Cellular Component Organization Regulation Of Protein Stability Regulation Of Protein Catabolic Process Nucleoplasm Programmed Cell Death	Cytoplasm Intracellular Signal Transduction
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