AATF and ZNF468

Number of citations of the paper that reports this interaction (PubMedID 21988832)
38

Data Source:
BioGRID (two hybrid)

		AATF	ZNF468
Description		apoptosis antagonizing transcription factor	zinc finger protein 468
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Transcription Regulator Complex Nucleolus Cytoplasm Small-subunit Processome	Nucleus
	Molecular Function	RNA Binding Protein Binding Leucine Zipper Domain Binding	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA Binding Zinc Ion Binding Metal Ion Binding
	Biological Process	Cell Adhesion Regulation Of Mitotic Cell Cycle Embryonic Cleavage Ribosome Biogenesis Ribosomal Small Subunit Biogenesis Negative Regulation Of Amyloid Precursor Protein Biosynthetic Process Negative Regulation Of Apoptotic Signaling Pathway	Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Regulation Of Gene Expression Negative Regulation Of Macromolecule Biosynthetic Process
Pathways		NRAGE signals death through JNK	Generic Transcription Pathway
Drugs
Diseases
GWAS		Body mass index ( 26426971) Erectile dysfunction ( 30583798) Obesity-related traits ( 23251661) Thyroid volume in Hashimoto’s thyroiditis ( 32019955)
Interacting Genes		29 interacting genes: ATM ATR AURKA CHEK1 CHEK2 CPD DAPK3 DAZAP2 EFNB3 FBXO7 HIPK2 LDOC1 LZTR1 MAPT MPHOSPH6 MYCBP2 NEDD4L PALS2 PARP1 PAWR PCBD2 POLR2J RB1 RELA SMAD3 SP1 SS18L1 TSG101 ZNF468	2 interacting genes: AATF NHERF1
Entrez ID		26574	90333
HPRD ID		12236	18344
Ensembl ID		ENSG00000275700	ENSG00000204604
Uniprot IDs		A0A7P0TAR0 A0A7P0TBG4 Q9NY61	Q5VIY5
PDB IDs		5W6A 7MQ8 7MQ9
Enriched GO Terms of Interacting Partners?		Ubiquitin Protein Ligase Binding Regulation Of Protein Metabolic Process Replicative Senescence Positive Regulation Of Metabolic Process Response To Gamma Radiation Regulation Of Cell Communication Regulation Of Signaling Regulation Of Signal Transduction By P53 Class Mediator Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Macromolecule Metabolic Process Regulation Of Primary Metabolic Process Cellular Response To Oxygen-containing Compound Regulation Of Signal Transduction Regulation Of Macromolecule Metabolic Process Positive Regulation Of Macromolecule Metabolic Process Regulation Of Cellular Component Organization Signal Transduction Involved In Regulation Of Gene Expression Negative Regulation Of Metabolic Process Regulation Of Metabolic Process Negative Regulation Of Gene Expression Regulation Of Gene Expression Negative Regulation Of Macromolecule Biosynthetic Process Regulation Of Apoptotic Process Regulation Of Organelle Organization Negative Regulation Of Protein Metabolic Process Negative Regulation Of Biosynthetic Process Regulation Of Programmed Cell Death PML Body Chromatin Organization Establishment Of RNA Localization To Telomere Establishment Of Protein-containing Complex Localization To Telomere Regulation Of Mitotic Nuclear Division Regulation Of Cellular Response To Heat Negative Regulation Of Mitotic Cell Cycle Positive Regulation Of Telomerase Catalytic Core Complex Assembly G2/M Transition Of Mitotic Cell Cycle Regulation Of Developmental Process Regulation Of Anatomical Structure Morphogenesis Protein Serine Kinase Activity Negative Regulation Of Cell Cycle Phase Transition Regulation Of Mitotic Cell Cycle Protein Kinase Activity Cell Cycle G2/M Phase Transition Apoptotic Process Protein Homodimerization Activity Positive Regulation Of Cellular Component Organization Regulation Of Protein Stability Regulation Of Protein Catabolic Process Nucleoplasm Programmed Cell Death	Microvillus Organization Negative Regulation Of Sodium Ion Transport Regulation Of Mitotic Cell Cycle Gamma-aminobutyric Acid Transport Regulation Of Apoptotic Signaling Pathway Golgi Localization Maintenance Of Epithelial Cell Apical/basal Polarity Bile Acid Secretion Maintenance Of Cell Polarity Type 2 Metabotropic Glutamate Receptor Binding Glutathione Transport Negative Regulation Of Platelet-derived Growth Factor Receptor Signaling Pathway Microvillus Assembly Type 3 Metabotropic Glutamate Receptor Binding Regulation Of Renal Phosphate Excretion Establishment Of Golgi Localization Negative Regulation Of Fibroblast Migration Channel Activator Activity Adenylate Cyclase-activating Dopamine Receptor Signaling Pathway Gamma-aminobutyric Acid Transmembrane Transporter Activity Dopamine Receptor Binding Beta-2 Adrenergic Receptor Binding Phospholipase C-activating Dopamine Receptor Signaling Pathway Renal Phosphate Ion Absorption Chloride Channel Regulator Activity Intracellular Phosphate Ion Homeostasis Gamma-aminobutyric Acid Import Growth Factor Receptor Binding Cerebrospinal Fluid Circulation Embryonic Cleavage Negative Regulation Of Amyloid Precursor Protein Biosynthetic Process Negative Regulation Of Glycoprotein Biosynthetic Process Leucine Zipper Domain Binding Plasma Membrane Protein Complex Stereocilium Tip Oligopeptide Transport Establishment Of Epithelial Cell Apical/basal Polarity Auditory Receptor Cell Stereocilium Organization Negative Regulation Of Glycoprotein Metabolic Process Regulation Of Amyloid Precursor Protein Biosynthetic Process Fibroblast Migration Phosphate Ion Homeostasis Establishment Of Apical/basal Cell Polarity G Protein-coupled Dopamine Receptor Signaling Pathway Renal Sodium Ion Transport Polarized Epithelial Cell Differentiation Establishment Of Monopolar Cell Polarity Establishment Or Maintenance Of Monopolar Cell Polarity Regulation Of Platelet-derived Growth Factor Receptor Signaling Pathway Acid Secretion
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