AATF and LZTR1

Number of citations of the paper that reports this interaction (PubMedID 20211142)
41

Data Source:
BioGRID (two hybrid)

		AATF	LZTR1
Description		apoptosis antagonizing transcription factor	leucine zipper like post translational regulator 1
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Transcription Regulator Complex Nucleolus Cytoplasm Small-subunit Processome	Endosome Golgi Apparatus Endomembrane System Membrane Cul3-RING Ubiquitin Ligase Complex Recycling Endosome Recycling Endosome Membrane
	Molecular Function	RNA Binding Protein Binding Leucine Zipper Domain Binding	Protein Binding Small GTPase Binding
	Biological Process	Cell Adhesion Regulation Of Mitotic Cell Cycle Embryonic Cleavage Ribosome Biogenesis Ribosomal Small Subunit Biogenesis Negative Regulation Of Amyloid Precursor Protein Biosynthetic Process Negative Regulation Of Apoptotic Signaling Pathway	Protein Ubiquitination Negative Regulation Of Ras Protein Signal Transduction
Pathways		NRAGE signals death through JNK
Drugs
Diseases
GWAS		Body mass index ( 26426971) Erectile dysfunction ( 30583798) Obesity-related traits ( 23251661) Thyroid volume in Hashimoto’s thyroiditis ( 32019955)
Interacting Genes		29 interacting genes: ATM ATR AURKA CHEK1 CHEK2 CPD DAPK3 DAZAP2 EFNB3 FBXO7 HIPK2 LDOC1 LZTR1 MAPT MPHOSPH6 MYCBP2 NEDD4L PALS2 PARP1 PAWR PCBD2 POLR2J RB1 RELA SMAD3 SP1 SS18L1 TSG101 ZNF468	54 interacting genes: AATF ANKRD53 ASB12 BMPR1B CEBPZ CHAF1A CNOT6L E2F8 EHMT1 FANK1 GABARAPL2 HCLS1 HDAC4 HRAS IKBKG KDM2B KRAS L3MBTL3 MCM3 MED16 MED7 MYBL2 NR1H3 NRAS PAPOLG PARP1 POLR1B POLR2B POLR2E RAI1 RERE RUVBL1 SCMH1 SND1 SP100 SREBF2 SSX4 STAT1 SUGP2 TAF11 TBX2 TCF19 TFAP2B TRIM5 TUBGCP4 WWP1 ZBTB1 ZNF137P ZNF175 ZNF451 ZNF490 ZNF584 ZNF714 ZZZ3
Entrez ID		26574	8216
HPRD ID		12236	08992
Ensembl ID		ENSG00000275700	ENSG00000099949
Uniprot IDs		A0A7P0TAR0 A0A7P0TBG4 Q9NY61	A0A384NL67 Q8N653
PDB IDs		5W6A 7MQ8 7MQ9
Enriched GO Terms of Interacting Partners?		Ubiquitin Protein Ligase Binding Regulation Of Protein Metabolic Process Replicative Senescence Positive Regulation Of Metabolic Process Response To Gamma Radiation Regulation Of Cell Communication Regulation Of Signaling Regulation Of Signal Transduction By P53 Class Mediator Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Macromolecule Metabolic Process Regulation Of Primary Metabolic Process Cellular Response To Oxygen-containing Compound Regulation Of Signal Transduction Regulation Of Macromolecule Metabolic Process Positive Regulation Of Macromolecule Metabolic Process Regulation Of Cellular Component Organization Signal Transduction Involved In Regulation Of Gene Expression Negative Regulation Of Metabolic Process Regulation Of Metabolic Process Negative Regulation Of Gene Expression Regulation Of Gene Expression Negative Regulation Of Macromolecule Biosynthetic Process Regulation Of Apoptotic Process Regulation Of Organelle Organization Negative Regulation Of Protein Metabolic Process Negative Regulation Of Biosynthetic Process Regulation Of Programmed Cell Death PML Body Chromatin Organization Establishment Of RNA Localization To Telomere Establishment Of Protein-containing Complex Localization To Telomere Regulation Of Mitotic Nuclear Division Regulation Of Cellular Response To Heat Negative Regulation Of Mitotic Cell Cycle Positive Regulation Of Telomerase Catalytic Core Complex Assembly G2/M Transition Of Mitotic Cell Cycle Regulation Of Developmental Process Regulation Of Anatomical Structure Morphogenesis Protein Serine Kinase Activity Negative Regulation Of Cell Cycle Phase Transition Regulation Of Mitotic Cell Cycle Protein Kinase Activity Cell Cycle G2/M Phase Transition Apoptotic Process Protein Homodimerization Activity Positive Regulation Of Cellular Component Organization Regulation Of Protein Stability Regulation Of Protein Catabolic Process Nucleoplasm Programmed Cell Death	Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Macromolecule Biosynthetic Process Nucleus Regulation Of Macromolecule Metabolic Process Regulation Of Gene Expression Regulation Of Primary Metabolic Process Regulation Of Transcription By RNA Polymerase II Regulation Of Metabolic Process Positive Regulation Of RNA Metabolic Process Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Positive Regulation Of Nucleobase-containing Compound Metabolic Process Nucleoplasm Positive Regulation Of Transcription By RNA Polymerase II Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of RNA Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Biosynthetic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of Biosynthetic Process Positive Regulation Of Macromolecule Metabolic Process Negative Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Macromolecule Metabolic Process Positive Regulation Of Metabolic Process DNA Binding Zinc Ion Binding Negative Regulation Of Metabolic Process Transcription By RNA Polymerase II DNA-templated Transcription RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Nuclear Body Nucleic Acid Metabolic Process Nucleolus Ribonucleoside Binding Transcription Coactivator Activity Chromatin Organization RNA Metabolic Process Regulation Of Transcription Initiation By RNA Polymerase II DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Transcription Regulator Complex DNA-directed RNA Polymerase Activity Regulation Of DNA-templated Transcription Initiation Chromo Shadow Domain Binding Chromatin Remodeling 5'-3' RNA Polymerase Activity
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