AATF and POLR2J

Number of citations of the paper that reports this interaction (PMID 10783144)
12

Data Source:
BioGRID (two hybrid, pull down)
HPRD (two hybrid, in vitro, in vivo)

		AATF	POLR2J
Gene Name		apoptosis antagonizing transcription factor	polymerase (RNA) II (DNA directed) polypeptide J, 13.3kDa
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Nucleolus Cytoplasm Golgi Apparatus Centrosome Focal Adhesion	Nucleus Nucleoplasm DNA-directed RNA Polymerase II, Core Complex
	Molecular Function	Sequence-specific DNA Binding Transcription Factor Activity Protein Binding Leucine Zipper Domain Binding Poly(A) RNA Binding Tau Protein Binding	RNA Polymerase II Activity DNA Binding DNA-directed RNA Polymerase Activity Protein Binding LRR Domain Binding Protein Dimerization Activity
	Biological Process	Cellular Response To DNA Damage Stimulus Cell Adhesion Regulation Of Mitotic Cell Cycle Negative Regulation Of Superoxide Anion Generation Embryonic Cleavage Ribosome Biogenesis Negative Regulation Of Amyloid Precursor Protein Biosynthetic Process Positive Regulation Of Apoptotic Process Negative Regulation Of Apoptotic Process Positive Regulation Of Transcription From RNA Polymerase II Promoter Neurotrophin TRK Receptor Signaling Pathway Apoptotic Signaling Pathway Negative Regulation Of Reactive Oxygen Species Metabolic Process	MRNA Splicing, Via Spliceosome DNA Repair Transcription-coupled Nucleotide-excision Repair Nucleotide-excision Repair Transcription From RNA Polymerase II Promoter Transcription Initiation From RNA Polymerase II Promoter Transcription Elongation From RNA Polymerase II Promoter 7-methylguanosine MRNA Capping RNA Splicing Gene Expression Viral Process PiRNA Metabolic Process Somatic Stem Cell Maintenance Positive Regulation Of Viral Transcription
Pathways		Signalling by NGF Cell death signalling via NRAGE, NRIF and NADE NRAGE signals death through JNK p75 NTR receptor-mediated signalling	RNA Polymerase II Promoter Escape mRNA Splicing Formation of HIV-1 elongation complex containing HIV-1 Tat PIWI-interacting RNA (piRNA) biogenesis Nucleotide Excision Repair RNA Polymerase II Transcription Pre-Initiation And Promoter Opening RNA Polymerase II Transcription Abortive elongation of HIV-1 transcript in the absence of Tat HIV Infection Regulatory RNA pathways Formation of the Early Elongation Complex Tat-mediated elongation of the HIV-1 transcript Tat-mediated HIV elongation arrest and recovery Formation of transcription-coupled NER (TC-NER) repair complex RNA Pol II CTD phosphorylation and interaction with CE RNA Polymerase II Pre-transcription Events Dual incision reaction in TC-NER Influenza Life Cycle HIV elongation arrest and recovery HIV Life Cycle HIV Transcription Initiation Influenza Viral RNA Transcription and Replication RNA Pol II CTD phosphorylation and interaction with CE Transcriptional regulation of pluripotent stem cells RNA Polymerase II HIV Promoter Escape HIV Transcription Elongation POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation Transcriptional regulation by small RNAs Processing of Capped Intron-Containing Pre-mRNA mRNA Capping mRNA Splicing - Minor Pathway mRNA Splicing - Major Pathway MicroRNA (miRNA) biogenesis Influenza Infection Pausing and recovery of Tat-mediated HIV elongation Late Phase of HIV Life Cycle Formation of RNA Pol II elongation complex RNA Polymerase II Transcription Initiation And Promoter Clearance Pausing and recovery of HIV elongation Formation of HIV elongation complex in the absence of HIV Tat Transcription-coupled NER (TC-NER) Viral Messenger RNA Synthesis Formation of the HIV-1 Early Elongation Complex RNA Polymerase II Transcription Initiation Transcription of the HIV genome RNA Polymerase II Transcription Elongation
Drugs
Diseases
GWAS		Obesity-related traits ( 23251661)
Protein-Protein Interactions		26 interactors: ATM ATR CHEK1 CHEK2 CPD DAPK3 DAZAP2 EFNB3 HIPK2 LDOC1 LZTR1 MAPT MPHOSPH6 MPP6 NEDD4L NGDN PAWR PCBD2 POLR2J RB1 RELA SMAD3 SP1 SS18L1 TSG101 ZNF468	8 interactors: AATF BAG6 CD14 LARP1B POLR1C POLR2C POLR2K SATB1
Entrez ID		26574	5439
HPRD ID		12236	16038
Ensembl ID		ENSG00000108270	ENSG00000005075
Uniprot IDs		Q9NY61	P52435
PDB IDs
Enriched GO Terms of Interacting Partners?		Replicative Senescence Viral Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process RNA Metabolic Process Nucleobase-containing Compound Metabolic Process Nitrogen Compound Metabolic Process Negative Regulation Of Biosynthetic Process Regulation Of Gene Expression DNA Damage Induced Protein Phosphorylation Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Cellular Biosynthetic Process Negative Regulation Of Cellular Metabolic Process Regulation Of Nitrogen Compound Metabolic Process Regulation Of Protein Metabolic Process Regulation Of RNA Biosynthetic Process Cell Aging Regulation Of RNA Metabolic Process Regulation Of Metabolic Process Transcription, DNA-templated Apoptotic Signaling Pathway RNA Biosynthetic Process Positive Regulation Of Gene Expression Regulation Of Protein Catabolic Process Biosynthetic Process Cellular Macromolecule Biosynthetic Process Negative Regulation Of Mitotic Cell Cycle Regulation Of Cell Cycle Cell Cycle Checkpoint Regulation Of Transcription, DNA-templated Regulation Of Mitotic Cell Cycle Macromolecule Biosynthetic Process Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Regulation Of Nucleic Acid-templated Transcription Apoptotic Process Positive Regulation Of Transcription, DNA-templated Negative Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Programmed Cell Death Negative Regulation Of Cell Cycle Cell Cycle Process Cell Death Death Regulation Of Mitotic Nuclear Division Response To Abiotic Stimulus Cell Differentiation Regulation Of Cell Proliferation Gene Expression Developmental Process Transforming Growth Factor Beta Receptor Signaling Pathway	DNA-templated Transcription, Elongation Termination Of RNA Polymerase III Transcription Transcription Elongation From RNA Polymerase III Promoter Termination Of RNA Polymerase I Transcription Transcription Elongation From RNA Polymerase I Promoter Transcription Initiation From RNA Polymerase I Promoter DNA-templated Transcription, Initiation 7-methylguanosine MRNA Capping Transcription From RNA Polymerase I Promoter PiRNA Metabolic Process 7-methylguanosine RNA Capping Cellular Response To DNA Damage Stimulus Response To Stress Transcription-coupled Nucleotide-excision Repair Positive Regulation Of Viral Transcription Transcription From RNA Polymerase III Promoter Apoptotic Process Programmed Cell Death Immune System Process Positive Regulation Of Cytokine Production Cell Death Death Transcription Elongation From RNA Polymerase II Promoter Somatic Stem Cell Maintenance Regulation Of Viral Transcription Positive Regulation Of Viral Process DNA-templated Transcription, Termination Negative Regulation Of Gene Expression, Epigenetic Positive Regulation Of Type I Interferon Production Nucleotide-excision Repair Regulation Of Cytokine Production Viral Process Regulation Of Type I Interferon Production Regulation Of Gene Expression Cellular Response To Stress Response To Stimulus Stem Cell Maintenance Regulation Of Viral Process Transcription Initiation From RNA Polymerase II Promoter Innate Immune Response Negative Regulation Of Amyloid Precursor Protein Biosynthetic Process Negative Regulation Of Superoxide Anion Generation Transcription From RNA Polymerase II Promoter Regulation Of Gene Expression, Epigenetic Tail-anchored Membrane Protein Insertion Into ER Membrane MRNA Splicing, Via Spliceosome RNA Splicing, Via Transesterification Reactions Stem Cell Development Transcription, DNA-templated Protein Insertion Into ER Membrane
Tagcloud ?		accuracy balb behavioral biomarker circadian comprising cooperativity crucial directed encoded exists explore fact forensic governs hence investigation keeping metabolism microrna mortem pmi reasonably rhythm rhythmicity rnome turn unambiguously view
Tagcloud (Difference) ?		accuracy balb behavioral biomarker circadian comprising cooperativity crucial directed encoded exists explore fact forensic governs hence investigation keeping metabolism microrna mortem pmi reasonably rhythm rhythmicity rnome turn unambiguously view
Tagcloud (Intersection) ?