PHGDH and PIAS4

Number of citations of the paper that reports this interaction (PMID 21988832)
14

Data Source:
BioGRID (two hybrid)

		PHGDH	PIAS4
Gene Name		phosphoglycerate dehydrogenase	protein inhibitor of activated STAT, 4
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Cytosol Extracellular Vesicular Exosome	Nucleus Nucleoplasm Cytoplasm Nuclear Matrix PML Body
	Molecular Function	Phosphoglycerate Dehydrogenase Activity Electron Carrier Activity NAD Binding	DNA Binding Protein Binding Zinc Ion Binding Ligase Activity SUMO Transferase Activity Ubiquitin Protein Ligase Binding SUMO Ligase Activity
	Biological Process	Glutamine Metabolic Process Glycine Metabolic Process L-serine Biosynthetic Process Threonine Metabolic Process Brain Development Cellular Amino Acid Biosynthetic Process Gamma-aminobutyric Acid Metabolic Process Regulation Of Gene Expression Taurine Metabolic Process Spinal Cord Development Glial Cell Development Neural Tube Development Neuron Projection Development Cellular Nitrogen Compound Metabolic Process Small Molecule Metabolic Process Oxidation-reduction Process G1 To G0 Transition	Negative Regulation Of Transcription From RNA Polymerase II Promoter Transcription, DNA-templated Wnt Signaling Pathway Protein Sumoylation Negative Regulation Of NF-kappaB Transcription Factor Activity Positive Regulation Of Protein Sumoylation Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Keratinocyte Apoptotic Process Positive Regulation Of Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage
Pathways		Serine biosynthesis Amino acid synthesis and interconversion (transamination) Metabolism of amino acids and derivatives
Drugs		NADH
Diseases
GWAS		Metabolic traits ( 21886157) Metabolite levels ( 23378610)
Protein-Protein Interactions		5 interactors: APP CHMP2B MAPK6 PIAS4 SUMO4	75 interactors: ACTN1 ALDOA AR BARD1 BRCA1 BTAF1 CALCOCO2 CEBPD CHD3 CLK1 COIL ESRRA FTH1 GADD45G HDAC1 HDAC2 HNF4A HNRNPUL1 HTT IL15RA IMMT IMPDH2 IRF3 IRF7 KPNB1 KRT18 LAMP2 LEF1 LRIF1 MAGEH1 MAP1LC3A MDC1 MPRIP NEFL NR4A2 OAZ1 OPTN PARP1 PDE4A PDE4D PDE4DIP PHF11 PHGDH PIAS1 PIAS2 PLAG1 PRPF40A PTN RIF1 SATB1 SERBP1 SERPINA5 SETDB1 SH3GL3 SKIL SMAD1 SMAD2 SMAD3 SMAD4 SMAD7 SNIP1 SUMO1 SUMO2 SUMO3 TADA3 TCERG1 TICAM1 TP53 TRIM27 TRIM32 UBE2I UBE2K VIM ZHX1 ZNF512B
Entrez ID		26227	51588
HPRD ID		06047	06910
Ensembl ID		ENSG00000092621
Uniprot IDs		O43175	Q8N2W9
PDB IDs		2G76
Enriched GO Terms of Interacting Partners?		Protein Sumoylation Positive Regulation Of Keratinocyte Apoptotic Process Synaptic Growth At Neuromuscular Junction Collateral Sprouting In Absence Of Injury Collateral Sprouting Axon Midline Choice Point Recognition Peptidyl-lysine Modification Smooth Endoplasmic Reticulum Calcium Ion Homeostasis Axon Choice Point Recognition Viral Budding Via Host ESCRT Complex Positive Regulation Of Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Cellular Protein Modification Process Regulation Of Mitotic Spindle Assembly Neuron Remodeling Viral Budding Regulation Of Spindle Assembly Positive Regulation Of Protein Sumoylation Regulation Of Mitotic Cell Cycle Regulation Of Mitotic Spindle Organization Cellular Copper Ion Homeostasis Cell Separation After Cytokinesis Regulation Of Cell Cycle Process Regulation Of Protein Sumoylation Copper Ion Homeostasis Suckling Behavior Cellular Protein Metabolic Process Virion Assembly	Negative Regulation Of Gene Expression Regulation Of Metabolic Process Regulation Of Gene Expression Cellular Nitrogen Compound Metabolic Process Regulation Of Transcription From RNA Polymerase II Promoter Transcription, DNA-templated RNA Biosynthetic Process Heterocycle Metabolic Process Nucleobase-containing Compound Metabolic Process Negative Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Regulation Of Nitrogen Compound Metabolic Process Nitrogen Compound Metabolic Process Cellular Aromatic Compound Metabolic Process Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Biosynthetic Process Negative Regulation Of Transcription From RNA Polymerase II Promoter Negative Regulation Of Nucleic Acid-templated Transcription Cellular Response To Organic Substance Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Negative Regulation Of Cellular Metabolic Process Transcription From RNA Polymerase II Promoter RNA Metabolic Process Regulation Of Transcription, DNA-templated Response To Organic Substance Regulation Of Cellular Process Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Transcription Initiation From RNA Polymerase II Promoter Gene Expression Response To Stimulus Positive Regulation Of Gene Expression Protein Sumoylation DNA-templated Transcription, Initiation Positive Regulation Of Transcription From RNA Polymerase II Promoter Cellular Macromolecule Biosynthetic Process Cellular Response To Organic Cyclic Compound Positive Regulation Of Transcription, DNA-templated Transforming Growth Factor Beta Receptor Signaling Pathway Response To Stress Macromolecule Biosynthetic Process Biosynthetic Process Positive Regulation Of Macromolecule Biosynthetic Process Intracellular Receptor Signaling Pathway Positive Regulation Of Metabolic Process Positive Regulation Of Cellular Biosynthetic Process Cellular Response To Transforming Growth Factor Beta Stimulus Positive Regulation Of Cellular Metabolic Process Response To Transforming Growth Factor Beta Regulation Of Cell Death
Tagcloud ?		amplified apoptotic biosynthesis catalyzes de deprivation dramatically frequently inhibits knockdown limiting melanoma melanomas mutated notably novo nutlin p53 promotes regulating retain reveal rnai sensitize serine starvation step suppresses suppressing	acceptor acetyltransferase alignment consensus consequently deacetylase dgcr8 e195a e3 ing ing1 ing1b ing2 ing3 ings isg15 k193 ligase marks mislocalized pdsm phosphomimic preferred reveals s199d stoichiometric sumo sumoylation suppressors
Tagcloud (Difference) ?		amplified apoptotic biosynthesis catalyzes de deprivation dramatically frequently inhibits knockdown limiting melanoma melanomas mutated notably novo nutlin p53 promotes regulating retain reveal rnai sensitize serine starvation step suppresses suppressing	acceptor acetyltransferase alignment consensus consequently deacetylase dgcr8 e195a e3 ing ing1 ing1b ing2 ing3 ings isg15 k193 ligase marks mislocalized pdsm phosphomimic preferred reveals s199d stoichiometric sumo sumoylation suppressors
Tagcloud (Intersection) ?