PHGDH and CHMP2B

Number of citations of the paper that reports this interaction (PMID 16730941)
46

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		PHGDH	CHMP2B
Gene Name		phosphoglycerate dehydrogenase	charged multivesicular body protein 2B
Image
Gene Ontology Annotations	Cellular Component	Cytosol Extracellular Vesicular Exosome	Intracellular Nucleus Nucleoplasm Cytoplasm Mitochondrion Cytosol Late Endosome Membrane Extracellular Vesicular Exosome
	Molecular Function	Phosphoglycerate Dehydrogenase Activity Electron Carrier Activity NAD Binding	Protein Binding Protein Domain Specific Binding
	Biological Process	Glutamine Metabolic Process Glycine Metabolic Process L-serine Biosynthetic Process Threonine Metabolic Process Brain Development Cellular Amino Acid Biosynthetic Process Gamma-aminobutyric Acid Metabolic Process Regulation Of Gene Expression Taurine Metabolic Process Spinal Cord Development Glial Cell Development Neural Tube Development Neuron Projection Development Cellular Nitrogen Compound Metabolic Process Small Molecule Metabolic Process Oxidation-reduction Process G1 To G0 Transition	Cell Separation After Cytokinesis Nucleus Organization Vacuolar Transport Mitotic Metaphase Plate Congression Regulation Of Centrosome Duplication Protein Transport Viral Process Endosomal Transport Viral Life Cycle Viral Budding Via Host ESCRT Complex Membrane Organization Regulation Of Mitotic Spindle Assembly
Pathways		Serine biosynthesis Amino acid synthesis and interconversion (transamination) Metabolism of amino acids and derivatives	HIV Life Cycle Budding and maturation of HIV virion HIV Infection Endosomal Sorting Complex Required For Transport (ESCRT) Late Phase of HIV Life Cycle
Drugs		NADH
Diseases
GWAS		Metabolic traits ( 21886157) Metabolite levels ( 23378610)
Protein-Protein Interactions		5 interactors: APP CHMP2B MAPK6 PIAS4 SUMO4	11 interactors: ATP5C1 CENPF CHMP3 DPY30 MALSU1 PHGDH PNMA1 TERF2IP TRAF2 USP54 USP8
Entrez ID		26227	25978
HPRD ID		06047	13174
Ensembl ID		ENSG00000092621	ENSG00000083937
Uniprot IDs		O43175	B2RE76 Q9UQN3
PDB IDs		2G76	2JQK
Enriched GO Terms of Interacting Partners?		Protein Sumoylation Positive Regulation Of Keratinocyte Apoptotic Process Synaptic Growth At Neuromuscular Junction Collateral Sprouting In Absence Of Injury Collateral Sprouting Axon Midline Choice Point Recognition Peptidyl-lysine Modification Smooth Endoplasmic Reticulum Calcium Ion Homeostasis Axon Choice Point Recognition Viral Budding Via Host ESCRT Complex Positive Regulation Of Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Cellular Protein Modification Process Regulation Of Mitotic Spindle Assembly Neuron Remodeling Viral Budding Regulation Of Spindle Assembly Positive Regulation Of Protein Sumoylation Regulation Of Mitotic Cell Cycle Regulation Of Mitotic Spindle Organization Cellular Copper Ion Homeostasis Cell Separation After Cytokinesis Regulation Of Cell Cycle Process Regulation Of Protein Sumoylation Copper Ion Homeostasis Suckling Behavior Cellular Protein Metabolic Process Virion Assembly	Negative Regulation Of DNA Recombination At Telomere Negative Regulation Of Mitochondrial Translation Regulation Of Organelle Organization Negative Regulation Of Chromosome Organization Cell Division
Tagcloud ?		amplified apoptotic biosynthesis catalyzes de deprivation dramatically frequently inhibits knockdown limiting melanoma melanomas mutated notably novo nutlin p53 promotes regulating retain reveal rnai sensitize serine starvation step suppresses suppressing	c9orf72 complexities counseling ethical fad familial frame frontotemporal ftd fus genetics grn gwas helping hexanucleotide mapt modifying multifactorial navigate pathogenetic presenilin progranulin psen1 psen2 reading tarbdp tardna valosin vcp
Tagcloud (Difference) ?		amplified apoptotic biosynthesis catalyzes de deprivation dramatically frequently inhibits knockdown limiting melanoma melanomas mutated notably novo nutlin p53 promotes regulating retain reveal rnai sensitize serine starvation step suppresses suppressing	c9orf72 complexities counseling ethical fad familial frame frontotemporal ftd fus genetics grn gwas helping hexanucleotide mapt modifying multifactorial navigate pathogenetic presenilin progranulin psen1 psen2 reading tarbdp tardna valosin vcp
Tagcloud (Intersection) ?