PHGDH

Description		phosphoglycerate dehydrogenase
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GO Annotations	Cellular Component	Cytosol Extracellular Exosome
	Molecular Function	Phosphoglycerate Dehydrogenase Activity Protein Binding Electron Transfer Activity Oxidoreductase Activity Oxidoreductase Activity, Acting On The CH-OH Group Of Donors, NAD Or NADP As Acceptor L-malate Dehydrogenase (NAD+) Activity NAD Binding
	Biological Process	Glutamine Metabolic Process Glycine Metabolic Process L-serine Metabolic Process L-serine Biosynthetic Process Threonine Metabolic Process Brain Development Amino Acid Biosynthetic Process Gamma-aminobutyric Acid Metabolic Process Regulation Of Gene Expression Taurine Metabolic Process Spinal Cord Development Glial Cell Development Neural Tube Development Neurogenesis Neuron Projection Development G1 To G0 Transition
Pathways		Serine metabolism
Drugs		NADH
Diseases
GWAS		Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL) ( 28090653) Glycine levels ( 31070104 30837465) Height ( 25282103) Hematocrit ( 32888494) Hemoglobin ( 32888494) Hemoglobin levels ( 32327693) Macular telangiectasia type 2 ( 33654266 28250457) Mean corpuscular hemoglobin ( 32888494) Mean spheric corpuscular volume ( 32888494) Metabolic traits ( 21886157) Metabolite levels ( 23378610) Multiple sclerosis ( 31604244 24076602) Nicotine dependence and major depression (severity of comorbidity) ( 30287806) Red blood cell count ( 27863252 32888494) Serum metabolite levels ( 33031748) Severe gingival inflammation ( 28459102) Total cholesterol levels ( 30275531)
Interacting Genes		11 interacting genes: APP CEBPA CHMP2B LINC01554 MAPK6 OGT PIAS4 PJA1 SIRT2 SUMO4 TTN
Entrez ID		26227
HPRD ID		06047
Ensembl ID		ENSG00000092621
Uniprot IDs		O43175
PDB IDs		2G76 5N53 5N6C 5NZO 5NZP 5NZQ 5OFM 5OFV 5OFW 6CWA 6PLF 6PLG 6RIH 6RJ2 6RJ3 6RJ5 6RJ6 7CVP 7DKM 7EWH 7VA1
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Proteolysis Negative Regulation Of RNA Biosynthetic Process Protein Metabolic Process Positive Regulation Of Protein Metabolic Process Regulation Of Proteolysis Negative Regulation Of DNA-templated Transcription Regulation Of Protein Catabolic Process Protein-containing Complex Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of DNA Binding Negative Regulation Of RNA Metabolic Process Nuclear Membrane Reassembly Negative Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Protein Localization Regulation Of Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Transcription By RNA Polymerase II Protein Modification Process Regulation Of Proteasomal Protein Catabolic Process Positive Regulation Of Catabolic Process Positive Regulation Of Protein Catabolic Process Transferase Activity Amyloid-beta Complex Growth Cone Lamellipodium Regulation Of Response To Calcium Ion Regulation Of Glycolytic Process Amylin Binding Positive Regulation Of Toll Signaling Pathway Macromolecule Metabolic Process RNA Polymerase I Transcription Regulatory Region Sequence-specific DNA Binding Protein N-acetylglucosaminyltransferase Complex Negative Regulation Of Non-canonical Inflammasome Complex Assembly Nuclear Membrane Organization Membrane Assembly Negative Regulation Of Oligodendrocyte Progenitor Proliferation Cellular Response To Caloric Restriction Positive Regulation Of Binding Regulation Of DNA Binding Protein Sumoylation Regulation Of Synapse Organization Regulation Of Carbohydrate Catabolic Process Autophagy Acetylcholine Receptor Activator Activity Regulation Of ATP Metabolic Process Cognition Protein-containing Complex Organization Response To Metal Ion Regulation Of Purine Nucleotide Metabolic Process Negative Regulation Of Macromolecule Biosynthetic Process Regulation Of Small Molecule Metabolic Process Positive Regulation Of Developmental Process
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