PHGDH

Gene Name		phosphoglycerate dehydrogenase
Image
Gene Ontology Annotations	Cellular Component	Cytosol Extracellular Vesicular Exosome
	Molecular Function	Phosphoglycerate Dehydrogenase Activity Electron Carrier Activity NAD Binding
	Biological Process	Glutamine Metabolic Process Glycine Metabolic Process L-serine Biosynthetic Process Threonine Metabolic Process Brain Development Cellular Amino Acid Biosynthetic Process Gamma-aminobutyric Acid Metabolic Process Regulation Of Gene Expression Taurine Metabolic Process Spinal Cord Development Glial Cell Development Neural Tube Development Neuron Projection Development Cellular Nitrogen Compound Metabolic Process Small Molecule Metabolic Process Oxidation-reduction Process G1 To G0 Transition
Pathways		Serine biosynthesis Amino acid synthesis and interconversion (transamination) Metabolism of amino acids and derivatives
Drugs		NADH
Diseases
GWAS		Metabolic traits ( 21886157) Metabolite levels ( 23378610)
Protein-protein Interactions		5 interactors: APP CHMP2B MAPK6 PIAS4 SUMO4
Entrez ID		26227
HPRD ID		06047
Ensembl ID		ENSG00000092621
Uniprot IDs		O43175
PDB IDs		2G76
Enriched GO Terms of Interacting Partners?		Protein Sumoylation Positive Regulation Of Keratinocyte Apoptotic Process Synaptic Growth At Neuromuscular Junction Collateral Sprouting In Absence Of Injury Collateral Sprouting Axon Midline Choice Point Recognition Peptidyl-lysine Modification Smooth Endoplasmic Reticulum Calcium Ion Homeostasis Axon Choice Point Recognition Viral Budding Via Host ESCRT Complex Positive Regulation Of Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Cellular Protein Modification Process Regulation Of Mitotic Spindle Assembly Neuron Remodeling Viral Budding Regulation Of Spindle Assembly Positive Regulation Of Protein Sumoylation Regulation Of Mitotic Cell Cycle Regulation Of Mitotic Spindle Organization Cellular Copper Ion Homeostasis Cell Separation After Cytokinesis Regulation Of Cell Cycle Process Regulation Of Protein Sumoylation Copper Ion Homeostasis Suckling Behavior Cellular Protein Metabolic Process Virion Assembly
Tagcloud ?		amplified apoptotic biosynthesis catalyzes de deprivation dramatically frequently inhibits knockdown limiting melanoma melanomas mutated notably novo nutlin p53 promotes regulating retain reveal rnai sensitize serine starvation step suppresses suppressing