SPAG8 and PRMT5

Number of citations of the paper that reports this interaction (PMID 23455924)
3

Data Source:
BioGRID (two hybrid)

		SPAG8	PRMT5
Gene Name		sperm associated antigen 8	protein arginine methyltransferase 5
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Acrosomal Vesicle Nucleus Membrane	Nucleus Nucleoplasm Cytoplasm Cytosol Methylosome
	Molecular Function	Molecular_function Microtubule Binding	Core Promoter Sequence-specific DNA Binding Chromatin Binding Transcription Corepressor Activity Protein Binding Methyltransferase Activity Histone-arginine N-methyltransferase Activity Protein-arginine Omega-N Symmetric Methyltransferase Activity Ribonucleoprotein Complex Binding
	Biological Process	Biological_process Positive Regulation Of Protein Binding Positive Regulation Of Transcription From RNA Polymerase II Promoter	Negative Regulation Of Transcription From RNA Polymerase II Promoter Spliceosomal SnRNP Assembly Chromatin Organization Transcription, DNA-templated Regulation Of Transcription, DNA-templated Regulation Of Mitotic Nuclear Division Cell Proliferation Gene Expression Peptidyl-arginine Methylation Peptidyl-arginine Methylation, To Symmetrical-dimethyl Arginine Circadian Regulation Of Gene Expression NcRNA Metabolic Process Peptidyl-arginine N-methylation Endothelial Cell Activation Histone H4-R3 Methylation
Pathways			Chromatin modifying enzymes snRNP Assembly Chromatin organization Metabolism of non-coding RNA RMTs methylate histone arginines
Drugs
Diseases
GWAS
Protein-Protein Interactions		15 interactors: CARM1 CSTF2 DTX2 JMJD4 KDM3B KLHL32 NEDD4L PITX1 PRMT1 PRMT2 PRMT5 RAN SNRPC UBQLN4 WHSC1L1	67 interactors: ARGLU1 CALU CAPN1 CCAR2 CDYL2 CLK1 CLK3 CLNS1A COPRS CTDP1 DIO3 DNMT3A EZH2 FAM76B GRHL3 GTPBP2 H3F3C HIST1H3A HIST1H4A HIST2H2AC HOXC4 ING5 JAK1 JAK2 JAK3 LDHAL6B LENG8 LUC7L MAGEB2 MBP MCRS1 MEF2D MYOD1 MYOG NELFCD NUDCD2 OLA1 PHYHIP PRPF38A RBM23 RSRP1 SF3A3 SIN3A SLU7 SMARCA2 SMARCB1 SMARCC1 SMARCE1 SNRNP70 SNRPB SNRPD1 SNRPD3 SPAG8 SSTR1 SUPT5H TRIB3 TYK2 WDR5 WDR77 YWHAG YWHAQ YWHAZ ZDHHC17 ZNF2 ZNF224 ZNF436 ZUFSP
Entrez ID		26206	10419
HPRD ID		12039	04955
Ensembl ID		ENSG00000137098	ENSG00000100462
Uniprot IDs		Q99932	O14744
PDB IDs			4GQB
Enriched GO Terms of Interacting Partners?		Peptidyl-arginine N-methylation Histone Arginine Methylation Peptidyl-arginine Methylation Histone Methylation Peptidyl-arginine Methylation, To Asymmetrical-dimethyl Arginine Protein Methylation Chromatin Modification Chromatin Organization Histone Modification Methylation Chromosome Organization Gene Expression Histone H4-R3 Methylation Regulation Of Transcription, DNA-templated RNA Metabolic Process Regulation Of Nucleic Acid-templated Transcription Transcription, DNA-templated Regulation Of RNA Biosynthetic Process Peptidyl-amino Acid Modification Regulation Of RNA Metabolic Process RNA Biosynthetic Process Nucleobase-containing Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Regulation Of Gene Expression Spliceosomal SnRNP Assembly Regulation Of Nitrogen Compound Metabolic Process MRNA Splicing, Via Spliceosome RNA Splicing, Via Transesterification Reactions Cellular Nitrogen Compound Metabolic Process Cellular Metabolic Process Regulation Of Intracellular Steroid Hormone Receptor Signaling Pathway Nitrogen Compound Metabolic Process Organelle Organization Histone H3-R17 Methylation Cellular Protein Modification Process Ribonucleoprotein Complex Biogenesis Intracellular Steroid Hormone Receptor Signaling Pathway RNA Splicing Regulation Of Metabolic Process Histone H3-R2 Methylation Peptidyl-arginine Methylation, To Symmetrical-dimethyl Arginine Positive Regulation Of Caveolin-mediated Endocytosis Cellular Macromolecule Biosynthetic Process MRNA Processing Macromolecule Biosynthetic Process Ribosomal Small Subunit Export From Nucleus Branchiomeric Skeletal Muscle Development MRNA 5'-splice Site Recognition Regulation Of Growth Plate Cartilage Chondrocyte Proliferation	Gene Expression RNA Metabolic Process Cellular Aromatic Compound Metabolic Process Nucleobase-containing Compound Metabolic Process Chromatin Organization Cellular Nitrogen Compound Metabolic Process Heterocycle Metabolic Process Chromatin Modification Regulation Of RNA Metabolic Process MRNA Processing Nitrogen Compound Metabolic Process Regulation Of Gene Expression Chromosome Organization Regulation Of Nitrogen Compound Metabolic Process Transcription, DNA-templated MRNA Metabolic Process RNA Splicing RNA Biosynthetic Process RNA Processing Regulation Of RNA Biosynthetic Process Cellular Metabolic Process Regulation Of Transcription, DNA-templated MRNA Splicing, Via Spliceosome Regulation Of Nucleic Acid-templated Transcription RNA Splicing, Via Transesterification Reactions Ribonucleoprotein Complex Assembly Spliceosomal SnRNP Assembly Positive Regulation Of Gene Expression Cellular Macromolecular Complex Assembly Histone Modification Positive Regulation Of Macromolecule Biosynthetic Process Metabolic Process Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Positive Regulation Of Transcription From RNA Polymerase II Promoter Ribonucleoprotein Complex Biogenesis Positive Regulation Of Cellular Biosynthetic Process Negative Regulation Of Gene Expression, Epigenetic Regulation Of Transcription From RNA Polymerase II Promoter Peptidyl-tyrosine Autophosphorylation Peptidyl-amino Acid Modification Positive Regulation Of Transcription, DNA-templated DNA Methylation On Cytosine Chromatin Remodeling Regulation Of Metabolic Process Positive Regulation Of Viral Transcription Single Stranded Viral RNA Replication Via Double Stranded DNA Intermediate Nucleosome Disassembly Transcription From RNA Polymerase II Promoter Positive Regulation Of Cellular Metabolic Process
Tagcloud ?		azoospermia bonferroni cgtg chinese conferred correction crem haplotype idiopathic iplex kif17b maturation noa nonobstructive played polymorphisms protective rs1148247 rs11592356 rs2295415 rs22954152 rs4934540 sequenom seventeen snps spermatogenesis tag tatg variants	acquisition af9 arginine biomedical bypassing cooperates critically drive drivers forming inactivating inherent lymphomagenesis lymphomas mll modulator neoplastic notch1 oncogenic overt relevance renewal revealing selectively specimen supporting suppresses sustaining transferase
Tagcloud (Difference) ?		azoospermia bonferroni cgtg chinese conferred correction crem haplotype idiopathic iplex kif17b maturation noa nonobstructive played polymorphisms protective rs1148247 rs11592356 rs2295415 rs22954152 rs4934540 sequenom seventeen snps spermatogenesis tag tatg variants	acquisition af9 arginine biomedical bypassing cooperates critically drive drivers forming inactivating inherent lymphomagenesis lymphomas mll modulator neoplastic notch1 oncogenic overt relevance renewal revealing selectively specimen supporting suppresses sustaining transferase
Tagcloud (Intersection) ?